Xavier Duval

TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.

TL;DR: The COVID Human Genetic Effort established to test the general hypothesis that life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2 with incomplete or complete penetrance finds an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001.

TL;DR: The relevant features of the first cases in Europe of confirmed infection, named coronavirus disease 2019 (COVID-19), with the first patient diagnosed with the disease on Jan 24, 2020, are reported and will contribute to advances in the implementation of more efficient infection control strategies.

TL;DR: From Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Régional Universitaire, and Unité Mixte de Recherche 6249 Chrono-environnement, Centre National de the Recherches Scientifique, Université de Franche-Comté, Besançon, France.

TL;DR: A randomized phase III trial is warranted to confirm that cetuximab may be considered as a therapeutic option especially in elderly patients, as a first-line treatment in patients with unresectable SCCS.