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Thomas K. F. Wong

Researcher at Australian National University

Publications -  52
Citations -  10550

Thomas K. F. Wong is an academic researcher from Australian National University. The author has contributed to research in topics: Structural alignment & Pseudoknot. The author has an hindex of 12, co-authored 50 publications receiving 6417 citations. Previous affiliations of Thomas K. F. Wong include Commonwealth Scientific and Industrial Research Organisation & Queensland University of Technology.

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ModelFinder: fast model selection for accurate phylogenetic estimates

TL;DR: ModelFinder is presented, a fast model-selection method that greatly improves the accuracy of phylogenetic estimates by incorporating a model of rate heterogeneity across sites not previously considered in this context and by allowing concurrent searches of model space and tree space.
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Phylogenomics resolves the timing and pattern of insect evolution

Bernhard Misof, +105 more
- 07 Nov 2014 - 
TL;DR: The phylogeny of all major insect lineages reveals how and when insects diversified and provides a comprehensive reliable scaffold for future comparative analyses of evolutionary innovations among insects.
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SOAP3-dp: Fast, Accurate and Sensitive GPU-based Short Read Aligner

TL;DR: Compared with widely adopted aligners including BWA, Bowtie2, SeqAlto, CUSHAW2, GEM and GPU-based aligners, SOAP3-dp was found to be two to tens of times faster, while maintaining the highest sensitivity and lowest false discovery rate (FDR) on Illumina reads with different lengths.
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SOAP3: ultra-fast GPU-based parallel alignment tool for short reads.

TL;DR: SOAP3 is the first short read alignment tool that leverages the multi-processors in a graphic processing unit (GPU) to achieve a drastic improvement in speed and aligns slightly more reads than BWA and Bowtie.
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Mixture models of nucleotide sequence evolution that account for heterogeneity in the substitution process across sites and across lineages

TL;DR: This work introduces a family of mixture models that approximate HAS without the assumption of an underlying predefined statistical distribution and presents two algorithms for searching model space and identifying an optimal model of evolution that is less likely to over- or underparameterize the data.