T
Timokratis Karamitros
Researcher at Pasteur Institute
Publications - 55
Citations - 757
Timokratis Karamitros is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 12, co-authored 43 publications receiving 394 citations. Previous affiliations of Timokratis Karamitros include Athens State University & National and Kapodistrian University of Athens.
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Journal ArticleDOI
SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies.
Timokratis Karamitros,Gethsimani Papadopoulou,Maria Bousali,Anastasios Mexias,Sotirios Tsiodras,Andreas Mentis +5 more
TL;DR: The isolated SNVs and genomic rearrangements reflect the intra-patient capacity of the polymorphic quasispecies, allowing immunological escape of the virus, offering resistance to anti-viral drugs and affecting the sensitivity of the molecular diagnostics assays.
Journal ArticleDOI
Studying severe long COVID to understand post-infectious disorders beyond COVID-19
Petter Brodin,Liam Townsend,Cliona O'Farrelly,Ivan Tancevski,Judith Löffler-Ragg,Trine H. Mogensen,Jean-Laurent Casanova,Laurent Abel,Alessandro Aiuti,Saleh Al-Muhsen,Fahd Al-Mulla,Mark E. Anderson,Evangelos Andreakos,Andrés Augusto Arias,Hagit Baris Feldman,Alexandre Belot,Catherine M. Biggs,Dusan Bogunovic,Alexandre Bolze,Anastasiia Bondarenko,Ahmed Aziz Bousfiha,Yenan T. Bryceson,C. Bustamante,Manish J. Butte,Giorgio Casari,John Christodoulou,Antonio Condino-Neto,Stefan N. Constantinescu,Megan A. Cooper,Clifton L. Dalgard,Murkesh Desai,Beth A. Drolet,Jamila El Baghdadi,Sara Elva Espinosa-Padilla,Jacques Fellay,Carlos Flores,José Luis Franco,Antoine Froidure,Peter K. Gregersen,Bodo Grimbacher,Filomeen Haerynck,David Hagin,Rabih Halwani,Lennart Hammarström,James R. Heath,Sarah E. Henrickson,Elena W Y Hsieh,Eystein S. Husebye,K. Imai,Yuval Itan,Erich D. Jarvis,Timokratis Karamitros,Kai Kisand,Chen-Lung Ku,Y.L. Lau,Yun Ling,Carrie L. Lucas,Tom Maniatis,Davood Mansouri,László Maródi,Isabelle Meyts,Joshua D. Miller,K. Mironska,Tomohiro Morio,Lisa F. P. Ng,Antonio Novelli,G. Novelli,Satoshi Okada,Keisuke Okamoto,Tayfun Ozcelik,Qiang Pan-Hammarström,Jean W. Pape,Rebeca Pérez de Diego,David S. Perlin,Graziano Pesole,A. Planas,Carolina Prando,Aurora Pujol,Lluis Quintana-Murci,Sathishkumar Ramaswamy,Laurent Rénia,Igor Resnick,Carlos Rodríguez-Gallego,Vanessa Sancho-Shimizu,Anna Sediva,Mikko Seppänen,Mohammed Shahrooei,Anna Shcherbina,Ondrej Slaby,Andrew L. Snow,Pere Soler-Palacín,András N Spaan,Stuart G. Tangye,Ahmad N. Abou Tayoun,Stuart E. Turvey,K. M. Furkan Uddin,Mohammed Jasim Uddin,Diederik van de Beek,Donald C. Vinh,Horst von Bernuth,Joost Wauters,Mayana Zatz,Pawel Zawadzki +102 more
Journal ArticleDOI
A novel method for the multiplexed target enrichment of MinION next generation sequencing libraries using PCR-generated baits
TL;DR: By capturing genomic fragments, which contain the target sequences, the authors recover reads extending targeted regions and thus can be used for the determination of potentially unknown flanking sequences and for the first time a standardized method for target enrichment in MinION platform.
Journal ArticleDOI
De Novo Assembly of Human Herpes Virus Type 1 (HHV-1) Genome, Mining of Non-Canonical Structures and Detection of Novel Drug-Resistance Mutations Using Short- and Long-Read Next Generation Sequencing Technologies.
Timokratis Karamitros,Ian Harrison,Renata Piorkowska,Aris Katzourakis,Gkikas Magiorkinis,Gkikas Magiorkinis,Jean L. Mbisa +6 more
TL;DR: A hybrid genome assembly protocol is employed using data from two sequencing technologies: the short-read Roche 454 and the long-read Oxford Nanopore MinION sequencers to improve the assembly of accurate, full-length HHV-1 genomes.
Journal ArticleDOI
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Paul Bastard,Sara E. Vazquez,Jamin Liu,Matthew T. Laurie,Chung Yu Wang,A Gervais,Tom Le Voyer,Lucy Bizien,Colin R. Zamecnik,Quentin Philippot,Jérémie Rosain,Emilie Catherinot,Andrew Willmore,A. Mitchell,Rebecca Bair,Pierre Garçon,Heather Kenney,Arnaud Fekkar,Maria Salagianni,Garyphallia Poulakou,Eleni Siouti,Sabina Sahanic,Günter Weiss,Laurenz Nagl,Jeremy Manry,Sotirija Duvlis,D. Arroyo-Sanchez,E Paz Artal,Luis Rubio,C. Perani,Michela Bezzi,Alessandra Sottini,Virginia Quaresima,Lucie Roussel,Donald C. Vinh,Luis F. Reyes,Margaux Garzaro,Nevin Hatipoğlu,David Boutboul,Yacine Tandjaoui-Lambiotte,Alessandro Borghesi,Anna Aliberti,Irene Cassaniti,Fabienne Venet,Guillaume Monneret,Rabih Halwani,Narjes Saheb Sharif-Askari,Jeffrey Danielson,Sonia Burrel,Caroline Morbieu,Y. Stepanovskyy,Anastasia Bondarenko,Alla Volokha,Oksana Boyarchuk,Alenka Gagro,Mathilde Neuville,Bénédicte Neven,Sevgi Keles,Romain Hernu,Antonin Bal,Kahina Saker,O. Ailioaie,Arnau Antolí,Eric Jeziorski,Gemma Rocamora-Blanch,C. Teixeira,Clarisse Delaunay,M. Lhuillier,Paul Le Turnier,Yu Zhang,Matthieu Mahévas,Hassan Abolhassani,T. Bompoil,Karim Dorgham,Guy Gorochov,Lisa F. P. Ng,Aurora Pujol,Alexandre Belot,François Raffi,Luis M. Allende,Javier Martinez-Picado,Tayfun Ozcelik,Luisa Imberti,Jesús Troya,Xavier Solanich,Shen-ying Zhang,Anne Puel,Michael R. Wilson,Sophie Trouillet-Assant,Emmanuelle Jouanguy,Chun Ye,Aurélie Cobat,Leslie M. Thompson,Evangelos Andreakos,Qian Zhang,Mark E. Anderson,Jean-Laurent Casanova,Joseph L. DeRisi,Laurent Abel,Cristian Achille,Alessandro Aiuti,Saleh Al-Muhsen,Fahd Al-Mulla,Mark Steven Anderson,Micol Angelini,Andrés Augusto Arias,Gokhan Aytekın,Fausto Baldanti,Hagit Baris Feldman,Federica Bergami,Catherine M. Biggs,Dusan Bogunovic,Alexandre Bolze,Anastasiia Bondarenko,Ahmed Aziz Bousfiha,Petter Brodin,Yenan T. Bryceson,Carlos Bustamante,Manish J. Butte,Giorgio Casari,John Christodoulou,Antonio Condino-Neto,Stefan N. Constantinescu,Francesca Conti,Megan A. Cooper,Clifton L. Dalgard,Murkesh Desai,Beth A. Drolet,Jamila El Baghdadi,Recai Ergun,D. L. Ergun,Sara Elva Espinosa-Padilla,Jacques Fellay,Carlos Flores,José Luis Franco,Antoine Froidure,Stefano Ghirardello,Peter K. Gregersen,Bodo Grimbacher,Filomeen Haerynck,David Hagin,Lennart Hammarström,James R. Heath,Sarah E. Henrickson,Elena W Y Hsieh,Eystein S. Husebye,K. Imai,Yuval Itan,Erich D. Jarvis,Fikret Kanat,Timokratis Karamitros,Kai Kisand,V. Kopcha,Mykhaylo Korda,Chen-Lung Ku,Yu-Lung Lau,Yun Ling,Carrie L. Lucas,Tom Maniatis,Davood Mansouri,László Maródi,Isabelle Meyts,Joshua D. Miller,K. Mironska,Trine H. Mogensen,Francesco Mojoli,Francisco Barreiro Morandeira,Tomohiro Morio,Luigi D. Notarangelo,Antonio Novelli,Giuseppe Novelli,Cliona O'Farrelly,Satoshi Okada,Keisuke Okamoto,Michele Pagani,Qiang Pan-Hammarström,Jean W. Pape,Rebeca Pérez de Diego,David S. Perlin,Graziano Pesole,Andrea Pession,Antonio Piralla,A. Planas,Carolina Prando,Lluis Quintana-Murci,Sathishkumar Ramaswamy,Laurent Rénia,Igor B. Resnick,Raül Rigo-Bonnin,Carlos Rodríguez-Gallego,Vanessa Sancho-Shimizu,Anna Sediva,Mikko Seppänen,Mohammed Shahrooei,Anna Shcherbina,Ondrej Slaby,Andrew L. Snow,Pere Soler-Palacín,András N Spaan,Ivan Tancevski,Stuart G. Tangye,Ahmad N. Abou Tayoun,Baykal Tulek,Stuart E. Turvey,K. M. Furkan Uddin,Mohammed Uddin,Bénédicte Clément,Yumiko Abe-Jones,Saurabh Asthana,S. Bhide,Carolyn S. Calfee,Sidney A. Carrillo,Suzanna Chak,Zachary A. Collins,David J. Erle,Gabriela K. Fragiadakis,Rajani Ghale,Carolyn M. Hendrickson,Alejandra Jáuregui,Kirsten N. Kangelaris,Matthew F. Krummel,Charles Langelier,Tasha Lea,Dea Hoon Lee,Aleksandra Leligdowicz,Carole Leroux,Raphael Lota,Michael A. Matthay,Viet Nguyen,Ravi S. Patel,Logan Pierce,Priya A. Prasad,Arjun A. Rao,Ahmad R. H. Rashid,N. Rodriguez,Bushra Samad,Cole Shaw,Austin Sigman,Kevin Tang,Luz Torres Altamirano,Alyssa Ward,Michael Wilson,Prescott G. Woodruff,Clotilde Allavena,Claire Andrejak,François Angoulvant,C. Azoulay,Delphine Bachelet,Marie Bartoli,Romain Basmaci,Sylvie Behilill,Marine Beluze,N. Benech,Dehbia Benkerrou,K. Bhavsar,Laurent Bitker,Lila Bouadma,Maude Bouscambert,Pauline Caraux Paz,Minerva Cervantes-Gonzalez,Anissa Chair,Catherine Chirouze,Alexandra Coelho,H Cordel,Camille Couffignal,Sandrine Couffin-Cadiergues,Eric D'Ortenzio,Etienne de Montmollin,Alexa Debard,Marie-Pierre Debray,Dominique Deplanque,Diane Descamps,Mathilde Desvallee,Alpha Diallo,Jean-Luc Diehl,Alphonsine Diouf,Céline Dorival,François Dubos,Xavier Duval,P Eloy,Vincent Enouf,Olivier Epaulard,Helene Esperou,Marina Esposito-Farèse,Manuel Etienne,Denis Garot,Nathalie Gault,Alexandre Gaymard,Jade Ghosn,Tristan Gigante,Morgane Gilg,François Goehringer,Jeremie Guedj,Alexandre Hoctin,Isabelle Hoffmann,Ikram Houas,Jean-Sébastien Hulot,S. Jaafoura,Ouifiya Kafif,Florentia Kaguelidou,Sabrina Kali,Younes Kerroumi,Antoine Khalil,Coralie Khan,Antoine Kimmoun,Fabrice Lainé,Cédric Laouénan,Samira Laribi,Minh Lê,Cyril Le Bris,Sylvie Le Gac,Quentin Le Hingrat,Soizic Le Mestre,Hervé Le Nagard,Adrien Lemaignen,Véronique Lemée,François-Xavier Lescure,Sophie Letrou,Yves Levy,Bruno Lina,Guillaume Lingas,Jean-Christophe Lucet,Moïse Machado,Denis Malvy,Marina Mambert,Al Manuel,F. Mentré,Amina Meziane,Hugo Mouquet,Jimmy Mullaert,Nadège Néant,Duc Nguyen,Marion Noret,Aurélie Papadopoulos,Christelle Paul,Nathan Peiffer-Smadja,Vincent Peigne,Ventzislava Petrov-Sanchez,Gilles Peytavin,Huong Pham,Olivier Picone,Valentine Piquard,Julien Poissy,Oriane Puéchal,Manuel Rosa-Calatrava,Benedicte Rossignol,Patrick Rossignol,Carine Roy,Marion Schneider,Richard D Su,Coralie Tardivon,Marie Capucine Tellier,François Téoulé,Olivier Terrier,Jean-François Timsit,Christelle Tual,Sarah Tubiana,S. Van Der Werf,N. Vanel,Aurelie Veislinger,Benoit Visseaux,Aurélie Wiedemann,Yazdan Yazdanpanah +362 more
TL;DR: Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.