C
Christian Mertes
Researcher at Technische Universität München
Publications - 21
Citations - 2156
Christian Mertes is an academic researcher from Technische Universität München. The author has contributed to research in topics: Gene & RNA splicing. The author has an hindex of 9, co-authored 17 publications receiving 1067 citations. Previous affiliations of Christian Mertes include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Jonas Schulte-Schrepping,Nico Reusch,Daniela Paclik,Kevin Baßler,Stephan Schlickeiser,Bowen Zhang,Benjamin Krämer,Tobias Krammer,Sophia Brumhard,Lorenzo Bonaguro,Elena De Domenico,Daniel Wendisch,Martin Grasshoff,Theodore S. Kapellos,Michael Beckstette,Tal Pecht,Adem Saglam,Oliver Dietrich,Henrik E. Mei,Axel Schulz,Claudia Conrad,Désirée Kunkel,Ehsan Vafadarnejad,Cheng-Jian Xu,Cheng-Jian Xu,Arik Horne,Miriam Herbert,Anna Drews,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Holger Müller-Redetzky,Katrin-Moira Heim,Felix Machleidt,Alexander Uhrig,Laure Bosquillon de Jarcy,Linda Jürgens,Miriam Stegemann,Christoph R. Glösenkamp,Hans-Dieter Volk,Christine Goffinet,Markus Landthaler,Emanuel Wyler,Philipp Georg,Maria Schneider,Chantip Dang-Heine,Nick Neuwinger,Kai Kappert,Rudolf Tauber,Victor M. Corman,Jan Raabe,Kim Melanie Kaiser,Michael To Vinh,Gereon Rieke,Christian Meisel,Thomas Ulas,Matthias Becker,Robert Geffers,Martin Witzenrath,Christian Drosten,Norbert Suttorp,Christof von Kalle,Florian Kurth,Florian Kurth,Florian Kurth,Kristian Händler,Joachim L. Schultze,Joachim L. Schultze,Anna C. Aschenbrenner,Anna C. Aschenbrenner,Yang Li,Yang Li,Jacob Nattermann,Birgit Sawitzki,Antoine-Emmanuel Saliba,Leif E. Sander,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colomé-Tatché,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Nikolaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Philip Rosenstiel,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Fabian J. Theis,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +137 more
TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
Journal ArticleDOI
Genetic diagnosis of Mendelian disorders via RNA sequencing
Laura S. Kremer,Daniel M. Bader,Daniel M. Bader,Christian Mertes,Robert Kopajtich,Garwin Pichler,Arcangela Iuso,Tobias B. Haack,Tobias B. Haack,Elisabeth Graf,Thomas Schwarzmayr,Caterina Terrile,Eliska Konafikova,Birgit Repp,Gabi Kastenmüller,Jerzy Adamski,Peter Lichtner,Christoph Leonhardt,Benoît Funalot,Alice Donati,Valeria Tiranti,Anne Lombès,Anne Lombès,Anne Lombès,Claude Jardel,Dieter Gläser,Robert W. Taylor,Daniele Ghezzi,Johannes A. Mayr,Agnès Rötig,Peter Freisinger,Felix Distelmaier,Tim M. Strom,Thomas Meitinger,Julien Gagneur,Julien Gagneur,Holger Prokisch +36 more
TL;DR: The power of transcriptome sequencing is demonstrated to molecularly diagnose 10% of mitochondriopathy patients and identify candidate genes for the remainder, and examples of intronic loss-of-function variants with pathological relevance are provided.
Journal ArticleDOI
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
Joana P. Bernardes,Neha Mishra,Florian Tran,Thomas Bahmer,Lena Best,Johanna I. Blase,Dora Bordoni,Jeanette Franzenburg,Ulf Geisen,Jonathan Josephs-Spaulding,Philipp Köhler,Axel Künstner,Elisa Rosati,Anna C. Aschenbrenner,Petra Bacher,Nathan Baran,Teide Boysen,Burkhard Brandt,Niklas Bruse,Jonathan Dörr,Andreas Dräger,Gunnar Elke,David Ellinghaus,Julia Fischer,Michael Forster,Andre Franke,Sören Franzenburg,Norbert Frey,Anette Friedrichs,Janina Fuß,Andreas Glück,Jacob Hamm,Finn Hinrichsen,Marc P. Hoeppner,Simon Imm,Ralf Junker,Sina Kaiser,Ying H. Kan,Rainer Knoll,Christoph Lange,Georg Laue,Clemens Lier,Matthias Lindner,Georgios Marinos,Robert Markewitz,Jacob Nattermann,Rainer Noth,Peter Pickkers,Klaus F. Rabe,Alina Renz,Christoph Röcken,Jan Rupp,Annika Schaffarzyk,Alexander Scheffold,Jonas Schulte-Schrepping,Jonas Schulte-Schrepping,Domagoj Schunk,Dirk Skowasch,Thomas Ulas,Thomas Ulas,Klaus-Peter Wandinger,Michael Wittig,Johannes Zimmermann,Hauke Busch,Bimba F. Hoyer,Christoph Kaleta,Jan Heyckendorf,Matthijs Kox,Jan Rybniker,Stefan Schreiber,Joachim L. Schultze,Joachim L. Schultze,Philip Rosenstiel,Nicholas E. Banovich,Tushar J. Desai,Oliver Eickelberg,Muzlifa Haniffa,Peter Horvath,Jonathan A. Kropski,Robert Lafyatis,Joakim Lundeberg,Kerstin B. Meyer,Martijn C. Nawijn,Marko Nikolic,Jose Ordovas Montanes,Dana Pe'er,Purushothama Rao Tata,Emma L. Rawlins,Aviv Regev,Paul A. Reyfman,Christos Samakovlis,Joachim Schultze,Alex K. Shalek,Douglas P. Shepherd,Jason R. Spence,Sarah A. Teichmann,Fabian J. Theis,Alexander M. Tsankov,Maarten van den Berge,Michael von Papen,Jeffrey A. Whitsett,Laure-Emmanuelle Zaragosi,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colme-Tatche,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Markus Landthaler,Yang Li,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Niklaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Antoine-Emmanuel Saliba,Leif E. Sander,Birgit Sawitzki,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +165 more
TL;DR: The study demonstrates broad cellular effects of SARS-CoV-2 infection beyond classical immune cells and may serve as an entry point to develop biomarkers and targeted treatments of patients with COVID-19.
Journal ArticleDOI
OUTRIDER: A Statistical Method for Detecting Aberrantly Expressed Genes in RNA Sequencing Data.
Felix Brechtmann,Christian Mertes,Agne Matuseviciute,Vicente A. Yépez,Žiga Avsec,Žiga Avsec,Maximilian Herzog,Daniel M. Bader,Holger Prokisch,Julien Gagneur,Julien Gagneur +10 more
TL;DR: OUTRIDER (Outlier in RNA-Seq Finder), an algorithm developed to address issues of covariation and significance-based thresholds, provides an end-to-end solution for identifying aberrantly expressed genes and is suitable for use by rare-disease diagnostic platforms.
Journal ArticleDOI
Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes
Maximilian Witzel,Daniel Petersheim,Yanxin Fan,Ehsan Bahrami,Tomas Racek,Meino Rohlfs,Jacek Puchałka,Christian Mertes,Julien Gagneur,Julien Gagneur,Christoph Ziegenhain,Wolfgang Enard,Asbjørg Stray-Pedersen,Peter D. Arkwright,Miguel R. Abboud,Vahid Pazhakh,Graham J. Lieschke,Peter Krawitz,Maik Dahlhoff,Marlon R. Schneider,Eckhard Wolf,Hans-Peter Horny,Heinrich Schmidt,Alejandro A. Schäffer,Christoph Klein +24 more
TL;DR: SMARCD2 is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.