W.H. Irwin McLean

TL;DR: This paper performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies.

TL;DR: In this article, an exposure-response relationship between exposure to peanut antigen in household dust and peanut skin prick test (SPT) sensitization and likely allergy was found, and an increase in 4 log 2 EPE units increased the odds of peanut SPT sensitization (1.71-fold, 95% CI, 1.13-to 2.59-fold; P ǫ =.01) and likely peanut allergy (PA; 2.10-fold), and 95% à 1.20-to 3.67-fold à Ã

TL;DR: This study suggests that 12‐month‐old infants with AD were not colonized with S aureus before having AD, and commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD.

TL;DR: Impairment of skin barrier function at birth and at 2 months precedes clinical AD, and these findings have implications for the optimal timing of interventions for the prevention of AD.

TL;DR: The results show that atopic dermatitis and psoriasis have distinct genetic mechanisms with opposing effects in shared pathways influencing epidermal differentiation and immune response.