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William R. Swindell
Researcher at Jewish Hospital
Publications - 78
Citations - 4889
William R. Swindell is an academic researcher from Jewish Hospital. The author has contributed to research in topics: Psoriasis & Gene expression profiling. The author has an hindex of 32, co-authored 72 publications receiving 3851 citations. Previous affiliations of William R. Swindell include University of Michigan & Heritage College of Osteopathic Medicine.
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Journal ArticleDOI
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Kevin J. Pearson,Joseph A. Baur,Kaitlyn N. Lewis,Leonid Peshkin,Nathan L. Price,Nathan L. Price,Nazar Labinskyy,William R. Swindell,Davida Kamara,Robin K. Minor,Evelyn Perez,Hamish A. Jamieson,Yongqing Zhang,Stephen R. Dunn,Kumar Sharma,Nancy Pleshko,Laura A. Woollett,Anna Csiszar,Yuji Ikeno,David G. Le Couteur,Peter J. Elliott,Kevin G. Becker,Plácido Navas,Donald K. Ingram,Norman S. Wolf,Zoltan Ungvari,David A. Sinclair,Rafael de Cabo +27 more
TL;DR: It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
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Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.
Bingshan Li,Bingshan Li,Lam C. Tsoi,William R. Swindell,Johann E. Gudjonsson,Trilokraj Tejasvi,Andrew Johnston,Jun Ding,Jun Ding,Philip E. Stuart,Xianying Xing,James J. Kochkodan,John J. Voorhees,Hyun Min Kang,Rajan P. Nair,Gonçalo R. Abecasis,James T. Elder +16 more
TL;DR: In this article, the authors used high-throughput complementary DNA sequencing (RNA-seq) to assay the transcriptomes of lesional psoriatic and normal skin, which revealed multiple modules of coordinately expressed epidermal differentiation genes, overlapping significantly with genes regulated by the long noncoding RNA TINCR.
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Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Lam C. Tsoi,Elke Rodriguez,Frauke Degenhardt,Hansjörg Baurecht,Ulrike Wehkamp,Natalie Volks,Silke Szymczak,William R. Swindell,Mrinal K. Sarkar,Kalpana Raja,Shuai Shao,Matthew Patrick,Yilin Gao,Ranjitha Uppala,Bethany E. Perez White,Spiro Getsios,Paul W. Harms,Emanual Michael Maverakis,James T. Elder,James T. Elder,Andre Franke,Johann E. Gudjonsson,Stephan Weidinger +22 more
TL;DR: This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Journal ArticleDOI
Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin
Lam C. Tsoi,Matthew K. Iyer,Philip E. Stuart,William R. Swindell,Johann E. Gudjonsson,Trilokraj Tejasvi,Mrinal K. Sarkar,Bingshan Li,Bingshan Li,Jun Ding,Jun Ding,John J. Voorhees,Hyun Min Kang,Rajan P. Nair,Arul M. Chinnaiyan,Gonçalo R. Abecasis,James T. Elder +16 more
TL;DR: It is found that many lncRNAs, in particular those that are differentially expressed, are co-expressed with genes involved in immune related functions, and that novel lnc RNAs are enriched for localization in the epidermal differentiation complex.
Journal ArticleDOI
Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse.
TL;DR: expression patterns identified in this analysis characterize a generalized response of mammalian cells to CR and/or aging, which may be of importance in determining effects of CR on overall lifespan, or as factors that underlie age-related disease.