Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.
Bingshan Li,Bingshan Li,Lam C. Tsoi,William R. Swindell,Johann E. Gudjonsson,Trilokraj Tejasvi,Andrew Johnston,Jun Ding,Jun Ding,Philip E. Stuart,Xianying Xing,James J. Kochkodan,John J. Voorhees,Hyun Min Kang,Rajan P. Nair,Gonçalo R. Abecasis,James T. Elder +16 more
TLDR
In this article, the authors used high-throughput complementary DNA sequencing (RNA-seq) to assay the transcriptomes of lesional psoriatic and normal skin, which revealed multiple modules of coordinately expressed epidermal differentiation genes, overlapping significantly with genes regulated by the long noncoding RNA TINCR.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2014-07-01 and is currently open access. It has received 292 citations till now. The article focuses on the topics: Gene expression profiling & RNA-Seq.read more
Citations
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Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis.
Kim A. Papp,Andrew Blauvelt,Michael Bukhalo,Melinda Gooderham,James G. Krueger,Jean-Philippe Lacour,Alan Menter,Sandra Philipp,Howard Sofen,Stephen Tyring,Beate R. Berner,Sudha Visvanathan,Chandrasena Pamulapati,Nathan Bennett,Mary Flack,Paul Scholl,Steven J. Padula +16 more
TL;DR: In this phase 2 trial, selective blockade of interleukin‐23 with risankizumab was associated with clinical responses superior to those associated with ustekinumab, and this trial was not large enough or of long enough duration to draw conclusions about safety.
Journal ArticleDOI
Long non-coding RNAs in the regulation of the immune response.
James A. Heward,Mark A. Lindsay +1 more
TL;DR: The current understanding of the mechanism of action of these immune-related lncRNAs is reviewed, their impact on physiological and pathological processes are discussed, and important areas of inquiry at the intersection between immunology and lncRNA biology are highlighted.
Journal ArticleDOI
Cytokines in psoriasis
TL;DR: A number of cytokines have been therapeutically targeted with success, revolutionizing treatment of this disease and are reviewed here to suggest potential therapeutic targets.
Journal ArticleDOI
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Lam C. Tsoi,Elke Rodriguez,Frauke Degenhardt,Hansjörg Baurecht,Ulrike Wehkamp,Natalie Volks,Silke Szymczak,William R. Swindell,Mrinal K. Sarkar,Kalpana Raja,Shuai Shao,Matthew Patrick,Yilin Gao,Ranjitha Uppala,Bethany E. Perez White,Spiro Getsios,Paul W. Harms,Emanual Michael Maverakis,James T. Elder,James T. Elder,Andre Franke,Johann E. Gudjonsson,Stephan Weidinger +22 more
TL;DR: This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Journal ArticleDOI
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture
Philip E. Stuart,Rajan P. Nair,Lam C. Tsoi,Trilokraj Tejasvi,Trilokraj Tejasvi,Sayantan Das,Hyun Min Kang,Eva Ellinghaus,Vinod Chandran,Kristina Callis-Duffin,Robert W. Ike,Yanming Li,Xiaoquan Wen,Charlotta Enerbäck,Johann E. Gudjonsson,Sulev Kõks,Sulev Kõks,Külli Kingo,Tõnu Esko,Ulrich Mrowietz,André Reis,H.-Erich Wichmann,H.-Erich Wichmann,Christian Gieger,Per Hoffmann,Markus M. Nöthen,Juliane Winkelmann,Manfred Kunz,Elvia G. Moreta,Philip J. Mease,Christopher T. Ritchlin,Anne M. Bowcock,Gerald G. Krueger,Henry W. Lim,Stephan Weidinger,Michael Weichenthal,John J. Voorhees,Proton Rahman,Peter K. Gregersen,Andre Franke,Dafna D. Gladman,Gonçalo R. Abecasis,James T. Elder,James T. Elder +43 more
TL;DR: A genome-wide association study to discern differences in genetic risk factors for PsA and cutaneous-only psoriasis (PsC) and finds multiple independent susceptibility variants in the IL12B, NOS2, and IFIH1 regions.
References
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