W
William T. Shearer
Researcher at Boston Children's Hospital
Publications - 13
Citations - 435
William T. Shearer is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Viral load & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 6, co-authored 13 publications receiving 422 citations. Previous affiliations of William T. Shearer include Harvard University & Baylor College of Medicine.
Papers
More filters
Journal ArticleDOI
First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial.
Linda Harrison,Abdel Babiker,Hannah Castro,Alexandra Compagnucci,Susan A. Fiscus,Carlo Giaquinto,Diana M. Gibb,Lynda Harper,Michael Hughes,Ross E. McKinney,Ann J. Melvin,Lynne M. Mofenson,Yacine Saidi,M. Elizabeth Smith,Gareth Tudor-Williams,A. Sarah Walker,Pim Brouwers,D. Costello,E. Ferguson,Janice Hodge,C. Jennings,Meredith G. Warshaw,Stephen A. Spector,E. R. Stiehm,Maripat Toye,Ram Yogev,J. P. Aboulker,A. De Rossi,J. Darbyshire,M. Debré,Nigel Klein,Deenan Pillay,B. Brody,C. Hill,P. Lepage,John F. Modlin,A. Poziak,M. Rein,Merlin L. Robb,T. Fleming,Stefano Vella,K. M. Kim,Rosa Bologna,D. Mecikovsky,N. Pineda,L. Sen,A. Mangano,S. Marino,C. Galvez,G. Deluchi,B. Zöhrer,W. Zenz,E. Daghofer,K. Pfurtscheller,B. Pabst,M. P. Gomez,P. McNeil,M. Jervis,I. Whyms,D. Kwolfe,S. Scott,M. M. Mussi-Pinhata,M. L. Issac,M. C. Cervi,B. V.M. Negrini,T. C. Matsubara,C. B. S. de Souza,J. C. Gabaldi,Ricardo H. Oliveira,M. C. Sapia,Thalita F. Abreu,Lucia de Araujo Evangelista,A. Pala,Iraina Fernandes,I. Farias,M. F. Melo,H. Carreira,L. M. Lira,M. della Negra,W. Queiroz,Y. C. Lian,D. P. Pacola,Jorge Pinto,F. Ferreira,F. Kakehasi,L. Martins,A. Diniz,V. Lobato,M. Diniz,S. Cleto,S. Costa,J. Romeiro,Catherine Dollfus,Marco Tabone,M. F. Courcoux,G. Vaudre,A. Dehée,A. Schnuriger,N. Le Gueyades,C. De Bortoli,F. Méchinaud,V. Reliquet,J. Arias,A. Rodallec,E. André,I. Falconi,A. Le Pelletier,F. Monpoux,J. Cottalorda,S. Mellul,E. Lachassinne,J. Galimand,Christine Rouzioux,Marie-Laure Chaix,Z. Benabadji,M. Pourrat,G. Firtion,D. Rivaux,M. Denon,N. Boudjoudi,F. Nganzali,A. Krivine,J. F. Méritet,G. Delommois,C. Norgeux,C. Guérin,C. Floch,L. Marty,H. Hichou,V. Tournier,Albert Faye,I. Le Moal,M. Sellier,L. Dehache,F. Damond,J. Leleu,D. Beniken,G. Alexandre-Castor,J. Neubert,T. Niehues,H. J. Laws,K. Huck,S. Gudowius,H. Loeffler,S. Bellert,A. Ortwin,G. Notheis,U. Wintergerst,F. Hoffman,A. Werthmann,S. Seyboldt,Laura Schneider,B. Bucholz,Cornelia Feiterna-Sperling,C. Peiser,R. Nickel,T. Schmitz,T. Piening,C. Müller,Gert Warncke,M. Wigger,R. Neubauer,Karina Butler,A. L. Chang,T. Belger,A. Menon,M. O’connell,L. Barrett,A. Rochford,M. Goode,E. Hayes,S. McDonagy,A. Walsh,A. Doyle,J. Fanning,M. O’connor,M. Byrne,N. O’sullivan,E. Hyland,Vania Giacomet,Alessandra Viganò,I. Colombo,Daria Trabattoni,Angela Berzi,Raffaele Badolato,F. Schumacher,V. Bennato,M. Brusati,A. Sorlini,Elena Spinelli,M. Filisetti,Cristina Bertulli,Osvalda Rampon,Marisa Zanchetta,Antonio Mazza,G. Stringari,G. Rossetti,Stefania Bernardi,Angela Di Martino,G. Castelli Gattinara,Paolo Palma,G. Pontrelli,H. Tchidjou,A. Furcas,C. Frillici,A. Mazzei,A. Zoccano,C. Concato,D. Duiculescu,Cristiana Oprea,G. Tardei,F. Abaab,M. Mardarescu,R. Draghicenoiu,D. Otelea,L. Alecsandru,R. Matusa,S. Rugina,M. Ilie,Silvia Netescu,C. Florea,E. Voicu,D. Poalelungi,C. Belmega,L. Vladau,J.T. Ramos Amador,M. I. Gonzalez Tomé,P. Rojo Conejo,M. Fernandez,R. Delgado Garcia,J. M. Ferrari,M. García López,M.J. Mellado Peña,P. Martín Fontelos,I. Jimenez Nacher,M. A. Muñoz Fernandez,J. L. Jimenez,A. García Torre,M. Penin,R. Pineiro Perez,I. Garcia Mellado,A. Finn,M. Lajeunesse,E. Hutchison,J. Usher,L. Ball,M. Dunn,Mike Sharland,K. Doerholt,S. Storey,S. Donaghy,C. Wells,K. Buckberry,P. Rice,P. McMaster,P. Butler,C. Farmer,J. Shenton,H. Haley,J. Orendi,J. Stroobant,L. Navarante,P. Archer,C. Mazhude,D. Scott,R. O’connell,J. Wong,G. Boddy,F. Shackley,R. Lakshman,J. Hobbs,G. Ball,G. Kudesia,J. Bane,D. Painter,K. Sloper,V. Shah,A. Cheng,A. Aali,C. Ball,S. Hawkins,D. Nayagam,A. Waters,S. Doshi,S. Liebeschuetz,B. Sodiende,Delane Shingadia,Delane Shingadia,S. Wong,J. Swan,Z. Shah,Andrew Collinson,C. Hayes,J. King,K. O’connor,Hermione Lyall,K. Fidler,S. Walters,Caroline Foster,D. Hamadache,C. Newbould,C. Monrose,S. Campbell,Shunmay Yeung,Jonathan Cohen,N. Martinez-Allier,D. Melvin,J. Dodge,S. Welch,G. Tatum,Anthony C. Gordon,S. Kaye,D. Muir,D. Patel,V. Novelli,D. Gibb,K. Moshal,John S. Lambert,J. Flynn,L. Farrelly,L. Farrelly,M. Clapson,L. S. Spencer,M. Depala,Marianne C. Jacobsen,S. Segal,Andrew J. Pollard,S. Yeadon,Y. Peng,Tao Dong,K. Jeffries,M. Snelling,A. Smyth,J. Smith,B. Ward,E Jungmann,C. Ryan,K. Swaby,A. Buckton,E. Smidt,Elaine J. Abrams,S. Champion,A. D. Fernandez,D. Calo,L. Garrovillo,K. Swaminathan,T. Alford,M. Frere,J. Navarra,William Borkowsky,S. Deygoo,T. Hastings,S. Akleh,T. Ilmet,K. Mohan,G. Bowen,Patricia Emmanuel,J. Lujan-Zimmerman,C. Rodriguez,S. Johnson,A. Marion,C. Graisbery,D. Casey,G. Lewis,Judith A. Guzman-Cottrill,R. Croteau,M. Acevedo-Flores,M. Gonzalez,L. Angeli,L. Fabregas,P. Valentin,Leonard B. Weiner,K. A. Contello,W. A. Holz,M. Butler,Sharon Nachman,M. A. Kelly,D. M. Ferraro,Sohail Rana,C. Reed,E. Yeagley,A. Malheiro,J. C. Roa,M. Neely,Andrea Kovacs,James Homans,Y. Rodriguez Lozano,Ana Puga,G. Talero,R. Sellers,R. Lawrence,Geoffrey A. Weinberg,Barbra Murante,Susan Laverty,A. Deveikis,J. Batra,T. Chen,D. Michalik,Jaime G. Deville,K. Elkins,S. Marks,J. Jackson Alvarez,J. Palm,I. Fineanganofo,M. Keuth,L. Deveikis,W. Tomosada,R. B. Van Dyke,T. Alchediak,Margarita Silio,C. Borne,S. Bradford,S. Eloby-Childress,K. Nguyen,Mobeen H. Rathore,A. Alvarez,Ayesha Mirza,Saniyyah Mahmoudi,M. Burke,I. L. Febo,L. Lugo,R. Santos,Joseph A. Church,T. Dunaway,C. Rodier,Patricia M. Flynn,N. Patel,S. Discenza,M. Donohoe,Katherine Luzuriaga,D. Picard,M. Kline,M. E. Paul,William T. Shearer,C. McMullen-Jackson,Ellen G. Chadwick,E. Cagwin,K. Kabat,Arry Dieudonne,Paul Palumbo,J. Johnson,S. Gaur,L. Cerracchio,Marc Foca,A. Jurgrau,S. Vasquez Bonilla,G. Silva,Anne A. Gershon,John L. Sullivan,Yvonne J. Bryson,Lisa M. Frenkel,J. Nelson,G. Hadjou,S. Léonardo,Yoann Riault,Y. Saïdi,L. Buck,J. H. Darbyshire,S. Forcat,J. Horton,D. Johnson,S. Moore,C. Taylor,D. Collins,S. Buskirk,P. Kamara,C. Nesel,M. Johnson,A. Ferreira,J. Tutko,H. Sprenger,Paula Britto,Christine A. Powell,R. Dersimonian,Edward Handelsman,Jintanat Ananworanich,E. Belfrage,S. Blanche,A. B. Bohlin,David M. Burger,Guido Castelli-Gattinara,Polly Clayden,R. de Groot,I. Grosch-Wörner,Marc Lallemant,Jay A. Levy,Magdalena Marczyńska,David Nadal,CS Peckham,L. Rosado,Raffaella Rosso,Christoph Rudin,Henriette J. Scherpbier,M. Stevanovic,Claire Thorne,Pier-Angelo Tovo,Niels Henrik Valerius +496 more
TL;DR: The long-term outcome of protease inhibitor and non-nucleoside reverse transcriptase inhibitor (NNRTI) first-line ART and viral load switch criteria in children with HIV is assessed.
Journal ArticleDOI
Quality of Life for Children and Adolescents: Impact of HIV Infection and Antiretroviral Treatment
Grace M. Lee,Steven L. Gortmaker,Kenneth McIntosh,Michael Hughes,James M. Oleske,Paul Palumbo,P. Andrew,Arry Dieudonne,B. Dashefsky,S. Gaur,Patricia Whitley-Williams,A. Malhotra,L. Cerracchio,Margaret A. Keller,J. Hayes,A. Gagajena,ChrisAnna M. Mink,Nancy Hutton,B. Griffith,M. Joyner,C. Kiefner,F. Minglana,M. E. Paul,William T. Shearer,C. D. Jackson,David W. Johnson,D. Kowalski,B. Wolfe,D. Ryan,A. Higgins,M. Foca,P. LaRussa,A. Gershon,Gwendolyn B. Scott,Charles D. Mitchell,L. Taybo,C. Gamber,Ann Petru,T. Courville,K. Gold,L. Johnson,Janice P. Piatt,J. Foti,L. Clarke-Steffen,T. Belho,B. Pitkin,J. Eddleman,Vincent R. Bonagura,S. J. Schuval,C. Colter,Elaine J. Abrams,M. Frere,D. Calo,S. Champion,Edward Handelsman,H. J. Moallem,D. M. Swindell,J. M. Kaye,M. Chin,K. Dorio,Andrew Wiznia,M. Donovan,M. Acevedo,M. Gonzalez,L. Fabregas,M. E. Texidor,W. A. Andiman,S. Romano,L. Hurst,J. De Jesus,Leonard B. Weiner,K. A. Contello,W. A. Holz,M. J. Famiglietti,Sharon Nachman,D. Nikolic-Djokic,D. Ferraro,J. Perillo,Sohail Rana,H. Finke-Castro,P. H. Yu,J. C. Roa,Mobeen H. Rathore,Abeer Khayat,K. Champion,S. Cusic,Patricia M. Flynn,Katherine M. Knapp,N. Patel,G. Wilson,Kathleen A. McGann,Larry K. Pickering,Gregory A. Storch,Steven D. Douglas,G. Koutsoubis,Richard M. Rutstein,Carol Vincent,M. Silio,T. Alchediak,C. Boe,M. Cowie,Barbara W. Stechenberg,D. J. Fisher,A. M. Johnston,Maripat Toye,Chitra S. Mani,S. Foshee,B. Kiean,S. Cobb,J. Farley,K. Klipner +110 more
TL;DR: Generally parents of HIV-infected children 6 months to 4 years and 5 to 11 years of age generally reported lower mean QoL scores than did parents of uninfected children, although worse psychological functioning was reported for unin infected children, and no consistent QOL differences among children receiving different antiretroviral regimens.
Journal ArticleDOI
Risk factors for preterm birth, low birth weight, and intrauterine growth retardation in infants born to HIV- infected pregnant women receiving zidovudine
John S. Lambert,D. H. Watts,Lynne M. Mofenson,E. R. Stiehm,D. R. Harris,James Bethel,Jean Whitehouse,Eleanor Jimenez,Jorge Gandia,Gwendolyn B. Scott,Mary Jo O'Sullivan,Andrea Kovacs,Alice Stek,William T. Shearer,Hunter Hammill,R. B. Van Dyke,R. Maupin,Margarita Silio,Mary Glenn Fowler +18 more
TL;DR: Risk factors for APO in antiretroviral treated HIV-infected women are similar to those reported for uninfected women, and data suggest that provision of prenatal care and ART may reduce APO.
Journal ArticleDOI
A comparative study of human immunodeficiency virus culture, polymerase chain reaction and anti-human immunodeficiency virus immunoglobulin a antibody detection in the diagnosis during early infancy of vertically acquired human immunodeficiency virus infection
Mark W. Kline,Dorothy E. Lewis,F. Blaine Hollinger,James M. Reuben,I. Celine Hanson,Claudia A. Kozinetz,Dimitre H. Dimitrov,Howard M. Rosenblatt,William T. Shearer +8 more
TL;DR: Culture and PCR detection offer excellent sensitivity and specificity for diagnosis of HIV infection during the first 6 months of life; however, false-negative HIV cultures sometimes are observed, particularly during the newborn period, and either false negative or false positive PCR test results may be noted occasionally.
Journal ArticleDOI
Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV
Russell B. Van Dyke,Kunjal Patel,Ron M. Kagan,Brad Karalius,Shirley Traite,William A. Meyer,Katherine Tassiopoulos,George R. Seage,Lorna M. Seybolt,Sandra K. Burchett,Rohan Hazra,Robert H. Lurie,Ram Yogev,Margaret Ann Sanders,Kathleen Malee,Scott J. Hunter,William T. Shearer,Mary E. Paul,Norma Cooper,Lynnette L. Harris,Murli Purswani,Mahboobullah Baig,Anna Cintron,Ana Puga,Sandra Navarro,Patricia A. Garvie,James Blood,Nancy Karthas,Betsy Kammerer,Andrew Wiznia,Marlene Burey,Molly L. Nozyce,Arry Dieudonne,Linda Bettica,Susan Adubato,Janet S Chen,Maria Garcia Bulkley,Latreaca Ivey,Mitzie Grant,Katherine M. Knapp,Kim J Allison,Megan L. Wilkins,Midnela Acevedo-Flores,Heida Rios,Vivian Olivera,Margarita Silio,Medea Jones,Patricia A. Sirois,Stephen A. Spector,Kim Norris,Sharon Nichols,Elizabeth J. McFarland,Alisa Katai,Jennifer Dunn,Suzanne Paul,Gwendolyn B. Scott,Patricia Bryan,Elizabeth Willen +57 more
TL;DR: Among 234 US youths with perinatal human immunodeficiency virus, 75% had antiretroviral resistance, substantially higher than that of the reference laboratory overall and the only factor independently associated with future resistance was a higher peak viral load.