Y
Yingrui Li
Researcher at Beijing Institute of Genomics
Publications - 182
Citations - 90736
Yingrui Li is an academic researcher from Beijing Institute of Genomics. The author has contributed to research in topics: Genome & Exome sequencing. The author has an hindex of 100, co-authored 182 publications receiving 76181 citations. Previous affiliations of Yingrui Li include South China University of Technology & University of Southern Denmark.
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Journal ArticleDOI
Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa
Xiangyu Ma,Liping Guan,Wei Wu,Yao Zhang,Wei Zheng,Yu-Tang Gao,Jirong Long,Na Wu,Long Wu,Ying Xiang,Bin Xu,Miaozhong Shen,Chen Yanhua,Wang Yuewen,Ye Yin,Yingrui Li,Haiwei Xu,Xun Xu,Yafei Li +18 more
TL;DR: A four-generation Chinese family with RP, during which 6 from 9 members of the second generation affected the disease, is reported, to enhance the current understanding of the genetic basis of RP and provide helpful clues for designing future studies to further investigate genetic factors for familial RP.
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Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder
Ditte Demontis,Francesco Lescai,Anders D. Børglum,Simon Glerup,Søren Dinesen Østergaard,Ole Mors,Qibin Li,Jieqin Liang,Hui Jiang,Yingrui Li,Jun Wang,Klaus-Peter Lesch,Andreas Reif,Jan K. Buitelaar,Barbara Franke +14 more
TL;DR: Many studies have attempted to identify genetic risk loci for the disorder, including numerous candidate gene studies and several moderately sized genome-wide association studies, the largest by the Psychiatric Genomics Consortium, but so far no single markers have passed the threshold for genome- wide significance.
Journal ArticleDOI
An exome sequencing pipeline for identifying and genotyping common CNVs associated with disease with application to psoriasis
Lachlan J. M. Coin,Dandan Cao,Jingjing Ren,Xianbo Zuo,Xianbo Zuo,Liangdan Sun,Liangdan Sun,Sen Yang,Sen Yang,Xuejun Zhang,Xuejun Zhang,Yong Cui,Yong Cui,Yingrui Li,Xin Jin,Jun Wang +15 more
TL;DR: ExoCNVTest: an exome sequencing analysis pipeline to identify disease-associated CNVs and to generate absolute copy number genotypes at putatively associated loci and re-discovered the LCE3B_LCE3C CNV association with psoriasis while controlling inflation of test statistics.
Journal ArticleDOI
Genomic landscapes of Chinese sporadic autism spectrum disorders revealed by whole-genome sequencing.
Jinyu Wu,Ping Yu,Xin Jin,Xiu Xu,Jinchen Li,Zhongshan Li,Mingbang Wang,Tao Wang,Xueli Wu,Yi Jiang,Wanshi Cai,Junpu Mei,Qingjie Min,Qiong Xu,Bingrui Zhou,Hui Guo,Ping Wang,Wenhao Zhou,Zhengmao Hu,Yingrui Li,Tao Cai,Yi Wang,Kun Xia,Yong-hui Jiang,Zhong Sheng Sun +24 more
TL;DR: The results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.
Posted ContentDOI
Construction of the third generation Zea mays haplotype map
Robert Bukowski,Xiaosen Guo,Yanli Lu,Cheng Zou,Bing He,Zhengqin Rong,Bo Wang,Dawen Xu,Bicheng Yang,Chuanxiao Xie,Longjiang Fan,Shibin Gao,Xun Xu,Gengyun Zhang,Yingrui Li,Yinping Jiao,John Doebley,Jeffrey Ross-Ibarra,Vince Buffalo,Edward S. Buckler,Yunbi Xu,Jinsheng Lai,Doreen Ware,Qi Sun +23 more
TL;DR: The authors identified polymorphisms in regions where collinearity is largely preserved in the maize species, however, the fact that the B73 genome used as the reference only represents a fraction of all haplotypes is still an important limiting factor.