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Yingrui Li
Researcher at Beijing Institute of Genomics
Publications - 182
Citations - 90736
Yingrui Li is an academic researcher from Beijing Institute of Genomics. The author has contributed to research in topics: Genome & Exome sequencing. The author has an hindex of 100, co-authored 182 publications receiving 76181 citations. Previous affiliations of Yingrui Li include South China University of Technology & University of Southern Denmark.
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Journal ArticleDOI
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes
Kirk E. Lohmueller,Thomas Sparsø,Qibin Li,Ehm A. Andersson,Thorfinn Sand Korneliussen,Anders Albrechtsen,Karina Banasik,Niels Grarup,Ingileif Hallgrimsdottir,Kristoffer Kiil,Tuomas O. Kilpeläinen,Nikolaj T. Krarup,Tune H. Pers,Tune H. Pers,Tune H. Pers,Gaston Sanchez,Youna Hu,Michael DeGiorgio,Torben Jørgensen,Torben Jørgensen,Annelli Sandbæk,Torsten Lauritzen,Søren Brunak,Karsten Kristiansen,Yingrui Li,Torben Hansen,Torben Hansen,Jun Wang,Rasmus Nielsen,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen +31 more
TL;DR: This study sequenced the exomes of 1,000 Danish cases with common forms of type 2 diabetes and healthy controls and applied a series of gene-based tests to detect susceptibility genes, but no gene showed a significant association with disease risk.
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Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration
Yan Liu,Qian Zhou,Yongjun Wang,Longhai Luo,Jian Yang,Linfeng Yang,Mei Liu,Yingrui Li,Tianmei Qian,Yuan Zheng,Meiyuan Li,Jiang Li,Yun Gu,Zujing Han,Man Xu,Yingjie Wang,Changlai Zhu,Bin Yu,Yumin Yang,Fei Ding,Jianping Jiang,Huanming Yang,Xiaosong Gu +22 more
TL;DR: Comparative genomic analysis reveals specific gene family expansions or reductions that are associated with the formation of adhesive setae, nocturnal vision and tail regeneration, as well as the diversification of olfactory sensation that provide robust genetic evidence of adaptive evolution in reptiles.
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Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly
Yingrui Li,Hancheng Zheng,Ruibang Luo,Ruibang Luo,Honglong Wu,Hongmei Zhu,Ruiqiang Li,Hongzhi Cao,Boxin Wu,Shujia Huang,Haojing Shao,Hanzhou Ma,Fan Zhang,Shuijian Feng,Wei Zhang,Hongli Du,Geng Tian,Jingxiang Li,Xiuqing Zhang,Songgang Li,Lars Bolund,Karsten Kristiansen,Adam J. de Smith,Alexandra I. F. Blakemore,Lachlan J. M. Coin,Huanming Yang,Jing Wang,Jun Wang +27 more
TL;DR: It is demonstrated that whole-genome de novo assembly is a feasible approach to deriving more comprehensive maps of genetic variation and can resolve complex rearrangements.
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Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing
Chang Yu,Jun Yu,Xiaotian Yao,William K.K. Wu,Youyong Lu,Senwei Tang,Xiangchun Li,Li Bao,Xiaoxing Li,Yong Hou,Renhua Wu,Min Jian,Ruoyan Chen,Fan Zhang,Lixia Xu,Fan Fan,Jun He,Qiaoyi Liang,Hongyi Wang,Xueda Hu,Minghui He,Xiang Zhang,Hancheng Zheng,Qibin Li,Hanjie Wu,Yan Chen,Xu Yang,Shida Zhu,Xun Xu,Huanming Yang,Jian Wang,Xiuqing Zhang,Joseph J.Y. Sung,Yingrui Li,Jun Wang +34 more
TL;DR: This study provides the first exome-wide evidence at single-cell level supporting that colon cancer could be of a biclonal origin, and suggests that low-prevalence mutations in a cohort may also play important protumorigenic roles at the individual level.
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Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1
Yanan Cao,Zhibo Gao,Lin Li,Xiuli Jiang,Aijing Shan,Jie Cai,Ying Peng,Yanli Li,Xiaohua Jiang,Xuanlin Huang,Jiaqian Wang,Qing Wei,Guijun Qin,Jiajun Zhao,Xiaolong Jin,Li Liu,Yingrui Li,Weiqing Wang,Jun Wang,Guang Ning +19 more
TL;DR: The identification of recurrent somatic T372R mutations in YY1 by whole exome sequencing of sporadic insulinomas highlights the importance of Yy1 in pancreatic β-cells and may provide therapeutic targets for PNETs.