Y
Yingrui Li
Researcher at Beijing Institute of Genomics
Publications - 182
Citations - 90736
Yingrui Li is an academic researcher from Beijing Institute of Genomics. The author has contributed to research in topics: Genome & Exome sequencing. The author has an hindex of 100, co-authored 182 publications receiving 76181 citations. Previous affiliations of Yingrui Li include South China University of Technology & University of Southern Denmark.
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Journal ArticleDOI
Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation
Jacob J. Michaelson,Yujian Shi,Madhusudan Gujral,Hancheng Zheng,Dheeraj Malhotra,Xin Jin,Minghan Jian,Guangming Liu,Douglas S. Greer,Abhishek Bhandari,Wenting Wu,Roser Corominas,Aine Peoples,Aine Peoples,Amnon Koren,Athurva Gore,Shuli Kang,Guan Ning Lin,Jasper A. Estabillo,Therese E. Gadomski,Balvindar Singh,Kun Zhang,Natacha Akshoomoff,Christina Corsello,Steven A. McCarroll,Lilia M. Iakoucheva,Yingrui Li,Jun Wang,Jun Wang,Jonathan Sebat +29 more
TL;DR: This article investigated global patterns of germline mutation by whole-genome sequencing of monozygotic twins concordant for ASD and their parents and found that hypermutability is a property of ASD genes and may also include nucleotide substitution hot spots.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Zhengyan Kan,Hancheng Zheng,Xiao Liu,Shuyu Li,Thomas D. Barber,Zhuolin Gong,Huan Gao,Ke Hao,Melinda D. Willard,Jiangchun Xu,Robert Hauptschein,Paul A. Rejto,Julio Fernandez,Guan Wang,Qinghui Zhang,Bo Wang,Ronghua Chen,Jian Wang,Nikki P. Lee,Wei Zhou,Zhao Lin,Zhiyu Peng,Kang Yi,Shengpei Chen,Lin Li,Xiaomei Fan,Jie Yang,Rui Ye,Jia Ju,Kai Wang,Heather Estrella,Shibing Deng,Ping Wei,Ming Qiu,Isabella H. Wulur,Jiangang Liu,Mariam Ehsani,Chunsheng Zhang,Andrey Loboda,Wing-Kin Sung,Wing-Kin Sung,Amit Aggarwal,Ronnie T.P. Poon,Sheung Tat Fan,Jun Wang,James S. Hardwick,James S. Hardwick,Christoph Reinhard,Hongyue Dai,Yingrui Li,John M. Luk,John M. Luk,John M. Luk,Mao Mao,Mao Mao +54 more
TL;DR: Findings from a whole-genome sequencing study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, find beta-catenin to be the mostrequently mutated oncogene and TP53 the most frequently mutated tumor suppressor.
Journal ArticleDOI
Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing
Yong-hui Jiang,Ryan K. C. Yuen,Xin Jin,Xin Jin,Mingbang Wang,Nong Chen,Xueli Wu,Jia Ju,Junpu Mei,Yujian Shi,Mingze He,Guangbiao Wang,Jieqin Liang,Zhe Wang,Dandan Cao,Melissa T. Carter,Christina Chrysler,Irene Drmic,Jennifer L. Howe,Lynette Lau,Christian R. Marshall,Christian R. Marshall,Daniele Merico,Thomas Nalpathamkalam,Bhooma Thiruvahindrapuram,Ann Thompson,Mohammed Uddin,Susan Walker,J. Luo,Evdokia Anagnostou,Lonnie Zwaigenbaum,Robert H. Ring,Jian Wang,Clara Lajonchere,Jun Wang,Andy Shih,Peter Szatmari,Huanming Yang,Geraldine Dawson,Geraldine Dawson,Yingrui Li,Stephen W. Scherer,Stephen W. Scherer +42 more
TL;DR: Results suggest that WGS and thorough bioinformatic analyses for de novo and rare inherited mutations will improve the detection of genetic variants likely to be associated with ASD or its accompanying clinical symptoms.
Journal ArticleDOI
The locust genome provides insight into swarm formation and long-distance flight
Xianhui Wang,Xiaodong Fang,Pengcheng Yang,Xuanting Jiang,Feng Jiang,Dejian Zhao,Bolei Li,Feng Cui,Jianing Wei,Chuan Ma,Wang Yundan,Jing He,Yuan Luo,Zhifeng Wang,Xiaojiao Guo,Wei Guo,Xuesong Wang,Yi Zhang,Meiling Yang,Shuguang Hao,Bing Chen,Zongyuan Ma,Dan Yu,Zhiqiang Xiong,Yabing Zhu,Dingding Fan,Lijuan Han,Bo Wang,Yuanxin Chen,Junwen Wang,Lan Yang,Wei Zhao,Yue Feng,Guanxing Chen,Jinmin Lian,Qiye Li,Zhiyong Huang,Xiaoming Yao,Na Lv,Guojie Zhang,Yingrui Li,Jian Wang,Jun Wang,Baoli Zhu,Le Kang +44 more
TL;DR: A draft 6.5 Gb genome sequence of Locusta migratoria is presented, which is the largest animal genome sequenced so far, and complex regulatory mechanisms involved in microtubule dynamic-mediated synapse plasticity during phase change are revealed.
Journal ArticleDOI
Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4
Holger Rohde,Junjie Qin,Yujun Cui,Dongfang Li,Nicholas J. Loman,Moritz Hentschke,Wentong Chen,Fei Pu,Yangqing Peng,Junhua Li,Feng Xi,Shenghui Li,Yin Li,Zhaoxi Zhang,Xianwei Yang,Meiru Zhao,Peng Wang,Yuanlin Guan,Zhong Cen,Xiangna Zhao,Martin Christner,Robin Kobbe,Sebastian Loos,Jun Oh,Liang Yang,Antoine Danchin,George F. Gao,Yajun Song,Yingrui Li,Huanming Yang,Jian Wang,Jianguo Xu,Mark J. Pallen,Jun Wang,Martin Aepfelbacher,Ruifu Yang +35 more
TL;DR: A cluster of cases associated with a single family is reported and an open-source genomic analysis of an isolate from one member of the family is described, revealing that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.