Y
Yoshiki Yamaguchi
Researcher at Tohoku Pharmaceutical University
Publications - 270
Citations - 7268
Yoshiki Yamaguchi is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 41, co-authored 247 publications receiving 6186 citations. Previous affiliations of Yoshiki Yamaguchi include University of Tokyo & Max Planck Society.
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Journal ArticleDOI
Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1.
Shigeki Matsumiya,Yoshiki Yamaguchi,Jun-ichi Saito,Mayumi Nagano,Hiroaki Sasakawa,Shizuo Otaki,Mitsuo Satoh,Kenya Shitara,Koichi Kato,Koichi Kato +9 more
TL;DR: Structural insight into the mechanisms of affinity enhancement suggest that the glycoform-dependent ADCC enhancement is attributed to a subtle conformational alteration in a limited region of IgG1-Fc.
Journal ArticleDOI
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain
Eri Sakata,Yoshiki Yamaguchi,Eiji Kurimoto,Jun Kikuchi,Shigeyuki Yokoyama,Shingo Yamada,Hiroyuki Kawahara,Hideyoshi Yokosawa,Nobutaka Hattori,Yoshikuni Mizuno,Keiji Tanaka,Koichi Kato +11 more
TL;DR: The findings suggest that the Arg 42 mutation induces a conformational change in the Rpn10‐binding site of Ubl, resulting in impaired proteasomal binding of parkin, which could be the cause of AR‐JP.
Journal ArticleDOI
Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy.
Yoshiki Yamaguchi,Mamiko Nishimura,Mayumi Nagano,Hirokazu Yagi,Hiroaki Sasakawa,Kazuhisa Uchida,Kenya Shitara,Koichi Kato +7 more
TL;DR: Results indicate that the carbohydrate moieties are required for maintaining the structural integrity of the FcgammaR-binding site.
Journal ArticleDOI
Protein encapsulation within synthetic molecular hosts
Daishi Fujita,Kosuke Suzuki,Sota Sato,Maho Yagi-Utsumi,Maho Yagi-Utsumi,Yoshiki Yamaguchi,Nobuhiro Mizuno,Takashi Kumasaka,Masaki Takata,Masanori Noda,Susumu Uchiyama,Koichi Kato,Koichi Kato,Makoto Fujita +13 more
TL;DR: The encapsulation of a small protein, ubiquitin, within giant coordination cages self-assembled around the protein-encapsulated structure could be analysed by NMR spectroscopy, ultracentrifugation and X-ray crystallography.
Journal ArticleDOI
Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy
Motoi Kanagawa,Kazuhiro Kobayashi,Michiko Tajiri,Hiroshi Manya,Atsushi Kuga,Yoshiki Yamaguchi,Keiko Akasaka-Manya,Jun-ichi Furukawa,Mamoru Mizuno,Hiroko Kawakami,Yasuro Shinohara,Yoshinao Wada,Tamao Endo,Tatsushi Toda +13 more
TL;DR: It is shown that enzyme activities of three major α-dystroglycanopathy-causing proteins are involved in the synthesis of tandem Rbo5P, a phosphoric ester of pentose alcohol in α-DG.