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Yusuke Ito
Researcher at University of Tokyo
Publications - 16
Citations - 7776
Yusuke Ito is an academic researcher from University of Tokyo. The author has contributed to research in topics: Adiponectin & Adiponectin receptor 1. The author has an hindex of 10, co-authored 16 publications receiving 7415 citations. Previous affiliations of Yusuke Ito include Hitotsubashi University.
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Journal ArticleDOI
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,Atsushi Tsuchida,Takehiko Yokomizo,Takehiko Yokomizo,Shunbun Kita,Takuya Sugiyama,Makoto Miyagishi,Makoto Miyagishi,Kazuo Hara,Masaki Tsunoda,Koji Murakami,Toshiaki Ohteki,S. Uchida,Sato Takekawa,Hironori Waki,Nelson H. Tsuno,Yoichi Shibata,Yasuo Terauchi,Philippe Froguel,Kazuyuki Tobe,Shigeo Koyasu,Kazunari Taira,Kazunari Taira,Toshio Kitamura,Takao Shimizu,Takao Shimizu,Ryozo Nagai,Takashi Kadowaki +29 more
TL;DR: The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Journal ArticleDOI
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.
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Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes MOLECULAR STRUCTURE AND MULTIMER FORMATION OF ADIPONECTIN
Hironori Waki,Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,S. Uchida,Shunbun Kita,Kazuo Hara,Yusuke Hada,Francis Vasseur,Philippe Froguel,Satoshi Kimura,Ryozo Nagai,Takashi Kadowaki +12 more
TL;DR: It is demonstrated that simple SDS-PAGE under non-reducing and non-heat-denaturing conditions clearly separates multimer species of adiponectin.
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Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasushi Imai,Nobuhiro Shimozawa,K. Hioki,S. Uchida,Yusuke Ito,Keisuke Takakuwa,Junji Matsui,Makoto Takata,Kazuhiro Eto,Yasuo Terauchi,Kajuro Komeda,Masaki Tsunoda,Koji Murakami,Yasuyuki Ohnishi,Takeshi Naitoh,Ken Ichi Yamamura,Yoshito Ueyama,Philippe Froguel,Satoshi Kimura,A. Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is shown that replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis, and this is the first demonstration that globular leptin can protect against Atherosclerosis in vivo.
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Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity
Atsushi Tsuchida,Toshimasa Yamauchi,Yusuke Ito,Yusuke Hada,Toshiyuki Maki,Sato Takekawa,Junji Kamon,Masaki Kobayashi,Ryo Suzuki,Kazuo Hara,Naoto Kubota,Yasuo Terauchi,Philippe Froguel,Jun Nakae,Masato Kasuga,Domenico Accili,Kazuyuki Tobe,Kohjiro Ueki,Ryozo Nagai,Takashi Kadowaki +19 more
TL;DR: The expression of AdipoR1/R2 appears to be inversely regulated by insulin in physiological and pathophysiological states such as fasting/refeeding, insulin deficiency, and hyper-insulinemia models via the insulin/phosphoinositide 3-kinase/Foxo1 pathway and is correlated with adiponectin sensitivity.