Z
Zhike Lu
Researcher at University of Chicago
Publications - 62
Citations - 25167
Zhike Lu is an academic researcher from University of Chicago. The author has contributed to research in topics: RNA & N6-Methyladenosine. The author has an hindex of 41, co-authored 56 publications receiving 17168 citations. Previous affiliations of Zhike Lu include Howard Hughes Medical Institute & Chinese Academy of Sciences.
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Journal ArticleDOI
N6-methyladenosine-dependent regulation of messenger RNA stability
Xiao Wang,Zhike Lu,Adrian Gomez,Gary C. Hon,Yanan Yue,Dali Han,Ye Fu,Marc Parisien,Qing Dai,Guifang Jia,Bing Ren,Tao Pan,Chuan He +12 more
TL;DR: It is shown that m6A is selectively recognized by the human YTH domain family 2 (YTHDF2) ‘reader’ protein to regulate mRNA degradation and established the role of YTH DF2 in RNA metabolism, showing that binding of Y THDF2 results in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processing bodies.
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Guanqun Zheng,John Arne Dahl,Yamei Niu,Peter Fedorcsak,Chun-Min Huang,Charles J. Li,Cathrine Broberg Vågbø,Yue Shi,Yue Shi,Wen-Ling Wang,Wen-Ling Wang,Shuhui Song,Zhike Lu,Ralph P. G. Bosmans,Qing Dai,Ya-Juan Hao,Ya-Juan Hao,Xin Yang,Xin Yang,Wenming Zhao,Wei-Min Tong,Xiu-Jie Wang,Florian Bogdan,Kari Furu,Ye Fu,Guifang Jia,Xu Zhao,Xu Zhao,Jun Liu,Hans E. Krokan,Arne Klungland,Yun-Gui Yang,Yun-Gui Yang,Chuan He +33 more
TL;DR: The discovery of ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo strongly suggests that the reversible m( 6)A modification has fundamental and broad functions in mammalian cells.
Journal ArticleDOI
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Xiao Wang,Xiao Wang,Boxuan Simen Zhao,Boxuan Simen Zhao,Ian A Roundtree,Ian A Roundtree,Zhike Lu,Zhike Lu,Dali Han,Dali Han,Honghui Ma,Honghui Ma,Xiaocheng Weng,Xiaocheng Weng,Kai Chen,Kai Chen,Hailing Shi,Hailing Shi,Chuan He,Chuan He +19 more
TL;DR: In a unified mechanism of m(6)A-based regulation in the cytoplasm, YTHDF2-mediated degradation controls the lifetime of target transcripts, whereasYTHDF1-mediated translation promotion increases translation efficiency, ensuring effective protein production from dynamic transcripts that are marked by m( 6)A.
Journal ArticleDOI
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Jianzhao Liu,Yanan Yue,Dali Han,Xiao Wang,Ye Fu,Liang Zhang,Guifang Jia,Miao Yu,Zhike Lu,Xin Deng,Qing Dai,Weizhong Chen,Chuan He +12 more
TL;DR: It is reported here that human METTL14 catalyzes m6A RNA methylation, and together with METTL3, the only previously known m 6A methyltransferase, these two proteins form a stable heterodimer core complex ofMETTL3-14 that functions in cellular m6 a deposition on mammalian nuclear RNAs.
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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.