Atomic Energy of Canada Limited

About: Atomic Energy of Canada Limited is a company organization based out in Ottawa, Ontario, Canada. It is known for research contribution in the topics: Neutron & Zirconium alloy. The organization has 4845 authors who have published 4826 publications receiving 102951 citations.

Dose Responses for Adaption to Low Doses of 60Co γ Rays and 3H β Particles in Normal Human Fibroblasts

Abstract: Broome, E. J., Brown, D. L. and Mitchel, R. E. J. Dose Responses for Adaption to Low Doses of 60Co γ Rays and 3H β Particles in Normal Human Fibroblasts. Radiat. Res. 158, 181–186 (2002). The dose response for adaption to radiation at low doses was compared in normal human fibroblasts (AG1522) exposed to either 60Co γ rays or 3H β particles. Cells were grown in culture to confluence and exposed at either 37°C or 0°C to 3H β-particle or 60Co γ-ray adapting doses ranging from 0.1 mGy to 500 mGy. These cells, and unexposed control cells, were allowed to adapt during a fixed 3-h, 37°C incubation prior to a 4-Gy challenge dose of 60Co γ rays. Adaption was assessed by measuring micronucleus frequency in cytokinesis-blocked, binucleate cells. No adaption was detected in cells exposed to 60Co γ radiation at 37°C after a dose of 0.1 mGy given at a low dose rate or to 500 mGy given at a high dose rate. However, low-dose-rate exposure (1–3 mGy/min) to any dose between 1 and 500 mGy from either radiation, de...