Birla Institute of Technology and Science

About: Birla Institute of Technology and Science is a education organization based out in Pilāni, Rajasthan, India. It is known for research contribution in the topics: Computer science & Population. The organization has 8897 authors who have published 13947 publications receiving 170008 citations.

Synthesis, Antiviral and Antibacterial Activities of Isatin Mannich Bases

Abstract: HIV is the most significant risk factor for many opportunistic infections like tuberculosis, hepatitis, bacterial infections etc. We designed an isatin lead compound as a novel non-nucleoside reverse transcriptase inhibitor with broad-spectrum chemotherapeutic properties for the effective treatment of AIDS and AIDS-related opportunistic infections. Compound 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[[N4-[3′-(4′-amino-5′-trimethoxybenzyl pyrimidin-2′-yl)imino-1′-(5-chloroisatinyl)[methyl]-N1-piperazinyl]-3-quinoline carboxylic acid (14) emerged as the most potent broad-spectrum chemotherapeutic agent active against HIV, HCV, M. tuberculosis and various pathogenic bacteria.

Testing star formation laws in a starburst galaxy at redshift 3 resolved with ALMA

Abstract: Using high-resolution (sub-kiloparsec scale) data obtained by ALMA, we analyse the star formation rate (SFR), gas content, and kinematics in SDP 81, a gravitationally lensed starburst galaxy at redshift 3. We estimate the SFR surface density (ΣSFR) in the brightest clump of this galaxy to be 357+135−85M⊙yr−1kpc−2, over an area of 0.07 ± 0.02 kpc2. Using the intensity-weighted velocity of CO (5–4), we measure the turbulent velocity dispersion in the plane of the sky and find σv, turb = 37 ± 5 km s−1 for the clump, in good agreement with previous estimates along the line of sight. Our measurements of the gas surface density, freefall time, and turbulent Mach number allow us to compare the theoretical SFR from various star formation models with that observed, revealing that the role of turbulence is crucial to explaining the observed SFR in this clump. While the Kennicutt–Schmidt (KS) relation predicts an SFR surface density of ΣSFR, KS = 52 ± 17 M⊙ yr−1 kpc−2, the single-freefall model by Krumholz, Dekel, and McKee (KDM) predicts ΣSFR, KDM = 106 ± 37 M⊙ yr−1 kpc−2. In contrast, the multifreefall (turbulence) model by Salim, Federrath, and Kewley (SFK) gives ΣSFR,SFK=491+139−194M⊙yr−1kpc−2. Although the SFK relation overestimates the SFR in this clump (possibly due to the negligence of magnetic fields), it provides the best prediction among the available models. Finally, we compare the star formation and gas properties of this galaxy to local star-forming regions and find that the SFK relation provides the best estimates of SFR in both local and high-redshift galaxies.

MBCP: Performance Analysis of Large Scale Mainstream Blockchain Consensus Protocols

Abstract: As Blockchain innovation picks up popularity in many areas, it is frequently hailed as a sound innovation. Because of the decentralization and encryption, many imagine that data put away in a Blockchain is and will consistently be protected. Among various abstraction layers of Blockchain architecture, the consensus layer is the core component behind the performance and security measures of the Blockchain network. Consensus mechanisms are a critical component of a Blockchain system’s long-term stability. Consensus forms the core of blockchain technology. Therefore, a range of consensus protocols has been introduced to maximize Blockchain systems’ efficiency and meet application domains’ individual needs. This research paper describes the layered architecture of Blockchain. A comprehensive review of mainstream consensus protocols mainly Proof of Work (PoW), Proof of Stake (PoS), Delegated Proof of Stake (DPoS), Proof of Activity (PoA) is presented in the paper. These mainstream consensus protocols have been explained and detailed performance analysis of these consensus protocols has been done. We have proposed a performance matrix of these consensus protocols based on different parameters like Degree of decentralization, Latency, Fault Tolerance Rate, Scalability, etc. Consensus protocols being the core of a strong fault-tolerant secured blockchain system, the proposed work intends to help inappropriate protocol selection and further research on strengthening trust and ownership in the technology. Depending upon different parameters like decentralization which is low in POA compared to other protocols, whereas POW is non-scalable, so depending on the priority of a particular performance parameter, the paper will help in the selection of a specific protocol.

Thin films of discotic liquid crystals and their applications

Abstract: Discotic liquid crystals (DLCs) are considered as fascinating systems due to their unique property of self-assembly to yield different columnar structures. DLCs are organic semiconductors and create pathways for the development of numerous optical and electrical devices. The thin films of DLCs can be considered as low dimensional system which can exhibit remarkable optical and physical properties. In this article, we present a review on ultrathin films of some interesting DLC molecules at air–water and air–solid interfaces. The Langmuir monolayer and Langmuir–Blodgett films of DLC molecules are extensively studied. The ultrathin films of DLC molecules can yield highly anisotropic layer wherein the molecular orientation and aggregation can have large impact on the physicochemical properties of the film. Different surface phases with different molecular orientations as function of surface density and temperature can be obtained by forming the Langmuir monolayer of the DLC molecules at the air–water ...