Birla Institute of Technology and Science

About: Birla Institute of Technology and Science is a education organization based out in Pilāni, Rajasthan, India. It is known for research contribution in the topics: Computer science & Population. The organization has 8897 authors who have published 13947 publications receiving 170008 citations.

compare-mt: A Tool for Holistic Comparison of Language Generation Systems

Abstract: In this paper, we describe compare-mt, a tool for holistic analysis and comparison of the results of systems for language generation tasks such as machine translation. The main goal of the tool is to give the user a high-level and coherent view of the salient differences between systems that can then be used to guide further analysis or system improvement. It implements a number of tools to do so, such as analysis of accuracy of generation of particular types of words, bucketed histograms of sentence accuracies or counts based on salient characteristics, and extraction of characteristic n-grams for each system. It also has a number of advanced features such as use of linguistic labels, source side data, or comparison of log likelihoods for probabilistic models, and also aims to be easily extensible by users to new types of analysis. compare-mt is a pure-Python open source package, that has already proven useful to generate analyses that have been used in our published papers. Demo Video: https://youtu.be/NyJEQT7t2CA

Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids

Abstract: Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has aroused great interest in medicinal chemists for the development of new drugs or drug candidates. The pharmacological activities of quinazoline and its related scaffolds include anti-cancer, anti-microbial, anti-convulsant, and antihyperlipidaemia. Recently, molecular hybridization technology is used for the development of hybrid analogues with improved potency by combining two or more pharmacophores of bioactive scaffolds. The molecular hybridization of various biologically active pharmacophores with quinazoline derivatives resulted in lead compounds with multi-faceted biological activity wherein specific as well as multiple targets were involved. The present review summarizes the advances in lead compounds of quinazoline hybrids and their related heterocycles in medicinal chemistry. Moreover, the review also helps to intensify the drug development process by providing an understanding of the potential role of these hybridized pharmacophoric features in exhibiting various pharmacological activities.

Effective Skin Cancer Treatment by Topical Co-delivery of Curcumin and STAT3 siRNA Using Cationic Liposomes

Abstract: The aim of the present study was to evaluate the effectiveness of iontophoretic co-delivery of curcumin and anti-STAT3 siRNA using cationic liposomes against skin cancer. Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA. This nanocomplex was characterized for the average particle size, zeta-potential, and encapsulation efficiency. The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p < 0.05) inhibited the cancer cell growth compared with either liposomal curcumin or STAT3 siRNA alone. The curcumin-loaded liposomes were able to penetrate up to a depth of 160 μm inside the skin after iontophoretic (0.47 mA/cm2) application. The in vivo efficacy studies were performed in the mouse model of melanoma skin cancer. Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p < 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone. Furthermore, the iontophoretic administration of curcumin-loaded liposome-siRNA complex showed similar effectiveness in inhibiting tumor progression and STAT3 protein suppression compared with intratumoral administration. Taken together, cationic liposomes can be utilized for topical iontophoretic co-delivery of small molecule and siRNA for effective treatment of skin diseases.