Institution
Charité
Healthcare•Berlin, Germany•
About: Charité is a healthcare organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 30624 authors who have published 64507 publications receiving 2437322 citations. The organization is also known as: Charite & Charité – University Medicine Berlin.
Topics: Population, Transplantation, Medicine, Cancer, Immune system
Papers published on a yearly basis
Papers
More filters
Charité1, Wayne State University2, Ottawa Hospital Research Institute3, University of Luxembourg4, University of Melbourne5, University of Freiburg6, Radboud University Nijmegen7, University of South Carolina8, University of Pittsburgh9, Northeastern University10, Harvard University11, University of Utah12
TL;DR: This work represents a multi‐institutional collaborative effort to develop a comprehensive, open source pipeline for DBS imaging and connectomics, which has already empowered several studies, and may facilitate a variety of future studies in the field.
473 citations
TL;DR: It is shown that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of Antiquitin as a Δ1-piperideine-6-carboxylate–α-aminoadipic semialdehyde (α-AASA) dehydrogenase.
Abstract: We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase. The accumulating P6C inactivates pyridoxal 5'-phosphate (PLP) by forming a Knoevenagel condensation product. Measurement of urinary alpha-AASA provides a simple way of confirming the diagnosis of PDS and ALDH7A1 gene analysis provides a means for prenatal diagnosis.
473 citations
TL;DR: It is shown that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca2+]i during cooling in heterologous systems.
Abstract: TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.
472 citations
TL;DR: Expectations regarding the effectiveness of methylphenidate and modafinil exceed their actual effects, as has been demonstrated in single- or double-blind randomised controlled trials.
472 citations
TL;DR: Eltrombopag is an effective treatment for managment of thrombocytopenia in chronic ITP and a dose increase to 75 mg is explored, and platelet counts generally returned to baseline values within 2 weeks after the end of treatment.
472 citations
Authors
Showing all 30787 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| JoAnn E. Manson | 270 | 1819 | 258509 |
| Yi Chen | 217 | 4342 | 293080 |
| David J. Hunter | 213 | 1836 | 207050 |
| Raymond J. Dolan | 196 | 919 | 138540 |
| John P. A. Ioannidis | 185 | 1311 | 193612 |
| Stefan Schreiber | 178 | 1233 | 138528 |
| Kenneth C. Anderson | 178 | 1138 | 126072 |
| Eric J. Nestler | 178 | 748 | 116947 |
| Klaus Rajewsky | 154 | 504 | 88793 |
| Charles B. Nemeroff | 149 | 979 | 90426 |
| Andreas Pfeiffer | 149 | 1756 | 131080 |
| Rinaldo Bellomo | 147 | 1714 | 120052 |
| Jean Bousquet | 145 | 1288 | 96769 |
| Christopher Hill | 144 | 1562 | 128098 |
| Holger J. Schünemann | 141 | 810 | 113169 |