Institution
Erasmus University Rotterdam
Education•Rotterdam, Zuid-Holland, Netherlands•
About: Erasmus University Rotterdam is a education organization based out in Rotterdam, Zuid-Holland, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 35466 authors who have published 91288 publications receiving 4510972 citations. The organization is also known as: EUR.
Papers published on a yearly basis
Papers
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University Medical Center Utrecht1, Radboud University Nijmegen Medical Centre2, Maastricht University Medical Centre3, University of Barcelona4, Goethe University Frankfurt5, University of Tübingen6, La Roche College7, Hospital Universitario de Canarias8, Creighton University Medical Center9, Erasmus University Rotterdam10, Harborview Medical Center11, State University of New York System12, Medical University of Vienna13, Hacettepe University14
TL;DR: The overall attributable mortality of ventilator-associated pneumonia is 13%, with higher rates for surgical patients and patients with a mid-range severity score at admission, which is mainly caused by prolonged exposure to the risk of dying due to increased length of ICU stay.
Abstract: Summary Background Estimating attributable mortality of ventilator-associated pneumonia has been hampered by confounding factors, small sample sizes, and the difficulty of doing relevant subgroup analyses. We estimated the attributable mortality using the individual original patient data of published randomised trials of ventilator-associated pneumonia prevention. Methods We identified relevant studies through systematic review. We analysed individual patient data in a one-stage meta-analytical approach (in which we defined attributable mortality as the ratio between the relative risk reductions [RRR] of mortality and ventilator-associated pneumonia) and in competing risk analyses. Predefined subgroups included surgical, trauma, and medical patients, and patients with different categories of severity of illness scores. Findings Individual patient data were available for 6284 patients from 24 trials. The overall attributable mortality was 13%, with higher mortality rates in surgical patients and patients with mid-range severity scores at admission (ie, acute physiology and chronic health evaluation score [APACHE] 20–29 and simplified acute physiology score [SAPS 2] 35–58). Attributable mortality was close to zero in trauma, medical patients, and patients with low or high severity of illness scores. Competing risk analyses could be done for 5162 patients from 19 studies, and the overall daily hazard for intensive care unit (ICU) mortality after ventilator-associated pneumonia was 1·13 (95% CI 0·98–1·31). The overall daily risk of discharge after ventilator-associated pneumonia was 0·74 (0·68–0·80), leading to an overall cumulative risk for dying in the ICU of 2·20 (1·91–2·54). Highest cumulative risks for dying from ventilator-associated pneumonia were noted for surgical patients (2·97, 95% CI 2·24–3·94) and patients with mid-range severity scores at admission (ie, cumulative risks of 2·49 [1·81–3·44] for patients with APACHE scores of 20–29 and 2·72 [1·95–3·78] for those with SAPS 2 scores of 35–58). Interpretation The overall attributable mortality of ventilator-associated pneumonia is 13%, with higher rates for surgical patients and patients with a mid-range severity score at admission. Attributable mortality is mainly caused by prolonged exposure to the risk of dying due to increased length of ICU stay. Funding None.
604 citations
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TL;DR: It is proposed that EB3-labeled growing microtubule ends regulate the localization of p140Cap, control cortactin function, and modulate actin dynamics within dendritic spines, thus linking dynamic microtubules to spine changes and synaptic plasticity.
604 citations
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TL;DR: Fibrin sealants have been investigated as matrices to promote wound healing and are important determinants of angiogenesis and differ in their cell growth stimulation, clotting rate, and fibrin polymerization characteristics.
604 citations
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Erasmus University Rotterdam1, University of Sussex2, Odense University3, University of Antwerp4, Stockholm School of Economics5, University of Bern6, Central Bureau of Statistics7, Clark University8, Economic and Social Research Institute9, University of Kent10, University of Bristol11, Uppsala University12
TL;DR: There is little or no evidence of significant inequity in the delivery of health care overall, though in half of the countries, significant pro-rich inequity emerges for physician contacts and in countries with very diverse characteristics regarding access and provider incentives.
602 citations
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Erasmus University Rotterdam1, University of Tennessee2, St Bartholomew's Hospital3, University of Michigan4, Harvard University5, Cedars-Sinai Medical Center6, University of Virginia7, Columbia University8, Queen Elizabeth Hospital Birmingham9, University of Texas MD Anderson Cancer Center10, University of North Carolina at Chapel Hill11, Sahlgrenska University Hospital12, New York University13, Oregon Health & Science University14, Emory University15, Ludwig Maximilian University of Munich16
TL;DR: Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration.
601 citations
Authors
Showing all 35695 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walter C. Willett | 334 | 2399 | 413322 |
Meir J. Stampfer | 277 | 1414 | 283776 |
Albert Hofman | 267 | 2530 | 321405 |
Graham A. Colditz | 261 | 1542 | 256034 |
Paul M. Ridker | 233 | 1242 | 245097 |
Ralph B. D'Agostino | 226 | 1287 | 229636 |
John Q. Trojanowski | 226 | 1467 | 213948 |
David J. Hunter | 213 | 1836 | 207050 |
André G. Uitterlinden | 199 | 1229 | 156747 |
Robert M. Califf | 196 | 1561 | 167961 |
Eric J. Topol | 193 | 1373 | 151025 |
Frank E. Speizer | 193 | 636 | 135891 |
Bernard Rosner | 190 | 1162 | 147661 |
William B. Kannel | 188 | 533 | 175659 |
Patrick W. Serruys | 186 | 2427 | 173210 |