Institution
Erasmus University Rotterdam
Education•Rotterdam, Zuid-Holland, Netherlands•
About: Erasmus University Rotterdam is a education organization based out in Rotterdam, Zuid-Holland, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 35466 authors who have published 91288 publications receiving 4510972 citations. The organization is also known as: EUR.
Papers published on a yearly basis
Papers
More filters
National Institutes of Health1, University of Minnesota2, Max Planck Society3, University College London4, Paul Sabatier University5, French Institute of Health and Medical Research6, University of Washington7, Boston University8, University of Tübingen9, deCODE genetics10, Columbia University Medical Center11, Erasmus University Rotterdam12, Stanford University13, University of Thessaly14, Washington University in St. Louis15, Michael J. Fox Foundation16, German Center for Neurodegenerative Diseases17, New York State Department of Health18, Centre national de la recherche scientifique19, University of Paris20, University of Miami21, Indiana University22
TL;DR: This article conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls.
Abstract: We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55–4.30; P = 2 × 10−16). We also show six risk loci associated with proximal gene expression or DNA methylation.
1,636 citations
University Medical Center Groningen1, University of Tartu2, University of Exeter3, Greifswald University Hospital4, National Institute for Health and Welfare5, University of Washington6, Churchill Hospital7, Technische Universität München8, University of Queensland9, University Medical Center Utrecht10, Erasmus University Rotterdam11, Leiden University Medical Center12, National Institutes of Health13, University College London14, University of Auckland15, QIMR Berghofer Medical Research Institute16, Wellcome Trust Centre for Human Genetics17, University of Düsseldorf18, Ludwig Maximilian University of Munich19, University of Groningen20, Group Health Cooperative21, Wellcome Trust Sanger Institute22, University of Helsinki23
TL;DR: Variants associated with cholesterol metabolism and type 1 diabetes showed similar phenomena, indicating that large-scale eQTL mapping provides insight into the downstream effects of many trait-associated variants.
Abstract: Identifying the downstream effects of disease-associated SNPs is challenging. To help overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in non-transformed peripheral blood samples from 5,311 individuals with replication in 2,775 individuals. We identified and replicated trans eQTLs for 233 SNPs (reflecting 103 independent loci) that were previously associated with complex traits at genome-wide significance. Some of these SNPs affect multiple genes in trans that are known to be altered in individuals with disease: rs4917014, previously associated with systemic lupus erythematosus (SLE), altered gene expression of C1QB and five type I interferon response genes, both hallmarks of SLE. DeepSAGE RNA sequencing showed that rs4917014 strongly alters the 3' UTR levels of IKZF1 in cis, and chromatin immunoprecipitation and sequencing analysis of the trans-regulated genes implicated IKZF1 as the causal gene. Variants associated with cholesterol metabolism and type 1 diabetes showed similar phenomena, indicating that large-scale eQTL mapping provides insight into the downstream effects of many trait-associated variants.
1,627 citations
TL;DR: In this article, the authors explore how organizational antecedents affect potential and realized absorptive capacity and find that organizational mechanisms associated with coordination capabilities (cross-functional interfaces, participation in decision making, and job rotation) primarily enhance a unit's potential absorptive capacities.
Abstract: Exploring how organizational antecedents affect potential and realized absorptive capacity, this study identifies differing effects for both components of absorptive capacity. Results indicate that organizational mechanisms associated with coordination capabilities (cross-functional interfaces, participation in decision making, and job rotation) primarily enhance a unit's potential absorptive capacity. Organizational mechanisms associated with socialization capabilities (connectedness and socialization tactics) primarily increase a unit's realized absorptive capacity. Our findings reveal why units may have difficulty managing levels of potential and realized absorptive capacity and vary in their ability to create value from their absorptive capacity.
1,627 citations
Johns Hopkins University1, Leipzig University2, Korea University3, Yale University4, West Virginia University5, University of Barcelona6, St George's, University of London7, Indiana University8, National Yang-Ming University9, Cleveland Clinic10, Aarhus University11, University at Buffalo12, Imperial College London13, Primary Children's Hospital14, Erasmus University Rotterdam15, Yeshiva University16, Ghent University17, Baylor University18, Virginia Commonwealth University19, Harvard University20, Federal University of São Paulo21, University of California, San Francisco22, Beaumont Hospital23, Boston University24, University of Oklahoma25, Carlos III Health Institute26, University of Michigan27, University of Melbourne28, Saint Louis University29, Université de Montréal30, University of Pennsylvania31, McGill University32, Mayo Clinic33, Lahey Hospital & Medical Center34, Royal Adelaide Hospital35, University of Milan36, University of Toronto37, Loyola University Chicago38, Jikei University School of Medicine39
TL;DR: This 2017 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a writing group, convened by these five international societies.
1,626 citations
University of Nottingham1, University of Edinburgh2, Case Western Reserve University3, New York University4, University of California, Los Angeles5, Southampton General Hospital6, Erasmus University Rotterdam7, Keele University8, University of Paris9, University of Maryland, Baltimore10, University of Sydney11, University of Pittsburgh12, Lund University13, University of Ottawa14
TL;DR: In this paper, a systematic literature search was undertaken using MEDLINE, EMBASE, CINAHL, AMED, Science Citation Index and the Cochrane Library to examine whether research evidence has changed from 31 January 2006 to 31 January 2009.
1,624 citations
Authors
Showing all 35695 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Walter C. Willett | 334 | 2399 | 413322 |
| Meir J. Stampfer | 277 | 1414 | 283776 |
| Albert Hofman | 267 | 2530 | 321405 |
| Graham A. Colditz | 261 | 1542 | 256034 |
| Paul M. Ridker | 233 | 1242 | 245097 |
| Ralph B. D'Agostino | 226 | 1287 | 229636 |
| John Q. Trojanowski | 226 | 1467 | 213948 |
| David J. Hunter | 213 | 1836 | 207050 |
| André G. Uitterlinden | 199 | 1229 | 156747 |
| Robert M. Califf | 196 | 1561 | 167961 |
| Eric J. Topol | 193 | 1373 | 151025 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Bernard Rosner | 190 | 1162 | 147661 |
| William B. Kannel | 188 | 533 | 175659 |
| Patrick W. Serruys | 186 | 2427 | 173210 |