Institution
Essentia Health
Healthcare•Duluth, Minnesota, United States•
About: Essentia Health is a healthcare organization based out in Duluth, Minnesota, United States. It is known for research contribution in the topics: Health care & Population. The organization has 198 authors who have published 278 publications receiving 3826 citations.
Topics: Health care, Population, Cancer, Randomized controlled trial, Medicine
Papers
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University of Washington1, National Institutes of Health2, Institute for Health Metrics and Evaluation3, Sapienza University of Rome4, Mayo Clinic5, FIU Herbert Wertheim College of Medicine6, Cincinnati Children's Hospital Medical Center7, Boston University8, Essentia Health9, University of Douala10, University of British Columbia11, Medical University of Graz12, Telethon Institute for Child Health Research13, University of Milan14, Cedars-Sinai Medical Center15, Johns Hopkins University16, University of California, San Diego17, University of Michigan18, University of Edinburgh19, University of Texas Southwestern Medical Center20, Queen Mary University of London21, University of Alabama at Birmingham22, Harvard University23, Tufts Medical Center24, All India Institute of Medical Sciences25, Northwestern University26, University of Kentucky27, Casa Sollievo della Sofferenza28, Columbia University29, Icahn School of Medicine at Mount Sinai30, University of Sydney31, University of Cape Town32, Federal University of Rio de Janeiro33, University of Ibadan34, Case Western Reserve University35, Stanford University36, Universidade Federal de Minas Gerais37, The George Institute for Global Health38, Uppsala University39, Dresden University of Technology40, King Fahd Medical City41, Tulane University42, Imperial College London43
TL;DR: CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high- income countries.
3,315 citations
Helfgott Research Institute1, University of Freiburg2, University of Oxford3, University of Ottawa4, Dartmouth College5, Ottawa Hospital Research Institute6, University of Southern California7, University of Mississippi Medical Center8, Rancho Los Amigos National Rehabilitation Center9, Cleveland Clinic10, Essentia Health11
TL;DR: This explanation and elaboration document is designed to increase the use and dissemination of the CARE Checklist in writing and publishing case reports and is resources for improving the completeness and transparency of case reports.
816 citations
TL;DR: In this article, the authors investigated changes in the fecal microbiota structure following FMT in patients with recurrent C. difficile infection, and imputed a hypothetical func- tional profile based on the 16S rRNA profile using a predictive metagenomic tool.
Abstract: Clostridium difficile infection is one of the most common health care-associated infections, and up to 40% of patients suffer from recurrence of disease following standard antibiotic therapy. Recently, fecal microbiota transplantation (FMT) has been successfully used to treat recurrent C. difficile infection. It is hypothesized that FMT aids in recovery of a microbiota capa- ble of colonization resistance to C. difficile. However, it is not fully understood how this occurs. Here we investigated changes in the fecal microbiota structure following FMT in patients with recurrent C. difficile infection, and imputed a hypothetical func- tional profile based on the 16S rRNA profile using a predictive metagenomic tool. Increased relative abundance of Bacteroidetes and decreased abundance of Proteobacteria were observed following FMT. The fecal microbiota of recipients following trans- plantation was more diverse and more similar to the donor profile than the microbiota prior to transplantation. Additionally, we observed differences in the imputed metagenomic profile. In particular, amino acid transport systems were overrepresented in samples collected prior to transplantation. These results suggest that functional changes accompany microbial structural changes following this therapy. Further identification of the specific community members and functions that promote coloniza- tion resistance may aid in the development of improved treatment methods for C. difficile infection. IMPORTANCE Within the last decade, Clostridium difficile infection has surpassed other bacterial infections to become the lead- ing cause of nosocomial infections. Antibiotic use, which disrupts the gut microbiota and its capability in providing colonization resistance against C. difficile, is a known risk factor in C. difficile infection. In particular, recurrent C. difficile remains difficult to treat with standard antibiotic therapy. Fecal microbiota transplantation (FMT) has provided a successful treatment method for some patients with recurrent C. difficile infection, but its mechanism and long-term effects remain unknown. Our results provide insight into the structural and potential metabolic changes that occur following FMT, which may aid in the development of new treatment methods for C. difficile infection.
280 citations
TL;DR: The basal subtype was associated with better survival, and the p53-like subtype Was associated with bone metastases and chemoresistant disease, and GEP was predictive of clinical UC outcomes.
222 citations
TL;DR: This study was a successful trial of a novel therapeutic agent targeting tight junction regulation in patients with CeD who are symptomatic despite a gluten-free diet, and results were mixed.
199 citations
Authors
Showing all 199 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Catherine A. McCarty | 88 | 408 | 31056 |
| Randall E. Millikan | 38 | 78 | 5623 |
| Christopher W. DiGiovanni | 35 | 197 | 4237 |
| Daniel A. Nikcevich | 26 | 68 | 2457 |
| Kenneth J. Dornfeld | 24 | 46 | 2168 |
| Steven E. Reinert | 23 | 55 | 2557 |
| Stephen C. Waring | 23 | 45 | 2209 |
| Colleen M. Renier | 19 | 74 | 1498 |
| Paula M. Termuhlen | 18 | 51 | 1249 |
| Rajshekhar Chakraborty | 18 | 66 | 827 |
| Irina V. Haller | 15 | 56 | 674 |
| Daniel M. Saman | 15 | 49 | 909 |
| Catherine P. Benziger | 15 | 30 | 1973 |
| Craig R. Lareau | 12 | 27 | 444 |
| Scott G. Thomas | 8 | 13 | 326 |