Institution
Free University of Berlin
Education•Berlin, Germany•
About: Free University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Context (language use). The organization has 35195 authors who have published 66525 publications receiving 2094403 citations. The organization is also known as: FU Berlin.
Topics: Population, Context (language use), Excited state, Receptor, Politics
Papers published on a yearly basis
Papers
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TL;DR: An overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.
Abstract: Polymer therapeutics encompass polymer-protein conjugates, drug-polymer conjugates, and supramolecular drug-delivery systems. Numerous polymer-protein conjugates with improved stability and pharmacokinetic properties have been developed, for example, by anchoring enzymes or biologically relevant proteins to polyethylene glycol components (PEGylation). Several polymer-protein conjugates have received market approval, for example the PEGylated form of adenosine deaminase. Coupling low-molecular-weight anticancer drugs to high-molecular-weight polymers through a cleavable linker is an effective method for improving the therapeutic index of clinically established agents, and the first candidates have been evaluated in clinical trials, including, N-(2-hydroxypropyl)methacrylamide conjugates of doxorubicin, camptothecin, paclitaxel, and platinum(II) complexes. Another class of polymer therapeutics are drug-delivery systems based on well-defined multivalent and dendritic polymers. These include polyanionic polymers for the inhibition of virus attachment, polycationic complexes with DNA or RNA (polyplexes), and dendritic core-shell architectures for the encapsulation of drugs. In this Review an overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.
1,047 citations
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TL;DR: School-based education does not reduce alcohol-related harm, although public information and education-type programmes have a role in providing information and in increasing attention and acceptance of alcohol on political and public agendas.
1,046 citations
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University of Reading1, University of Oxford2, Stony Brook University3, Imperial College London4, Rutherford Appleton Laboratory5, Free University of Berlin6, Oeschger Centre for Climate Change Research7, University of Massachusetts Amherst8, University of Arizona9, University of Giessen10, National Center for Atmospheric Research11, Goddard Institute for Space Studies12, University of Amsterdam13, University of California, San Diego14
TL;DR: In this paper, the development of this review article has evolved from work carried out by an international team of the International Space Science Institute (ISSI), Bern, Switzerland, and from work performed under the auspices of Scientific Committee on Solar Terrestrial Physics (SCOSTEP) regarding climate and weather of the Sun-Earth System (CAWSES).
Abstract: The development of this
review article has evolved from work carried out by an international
team of the International Space Science Institute (ISSI),
Bern, Switzerland, and from work carried out under the auspices
of Scientific Committee on Solar Terrestrial Physics (SCOSTEP)
Climate and Weather of the Sun‐Earth System (CAWSES‐1).
The support of ISSI in providing workshop and meeting facilities
is acknowledged, especially support from Y. Calisesi and V. Manno.
SCOSTEP is acknowledged for kindly providing financial assistance
to allow the paper to be published under an open access
policy. L.J.G. was supported by the UK Natural Environment
Research Council (NERC) through their National Centre for Atmospheric
Research (NCAS) Climate program. K.M. was supported
by a Marie Curie International Outgoing Fellowship within the
6th European Community Framework Programme. J.L. acknowledges
support by the EU/FP7 program Assessing Climate Impacts
on the Quantity and Quality of Water (ACQWA, 212250) and from
the DFG Project Precipitation in the Past Millennium in Europe
(PRIME) within the Priority Program INTERDYNAMIK. L.H.
acknowledges support from the U.S. NASA Living With a Star
program. G.M. acknowledges support from the Office of Science
(BER), U.S. Department of Energy, Cooperative Agreement
DE‐FC02‐97ER62402, and the National Science Foundation. We
also wish to thank Karin Labitzke and Markus Kunze for supplying
an updated Figure 13, Andrew Heaps for technical support, and
Paul Dickinson for editorial support. Part of the research was
carried out under the SPP CAWSES funded by GFG. J.B. was
financially supported by NCCR Climate–Swiss Climate Research.
1,045 citations
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TL;DR: In this paper, the necessary and sufficient conditions for Euclidean Green's functions to have analytic continuations to a relativistic field theory were given, extending and correcting a previous paper.
Abstract: We give new (necessary and) sufficient conditions for Euclidean Green's functions to have analytic continuations to a relativistic field theory. These results extend and correct a previous paper.
1,033 citations
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TL;DR: It is established that the mean dissipated heat saturates at the Landauer bound in the limit of long erasure cycles, demonstrating the intimate link between information theory and thermodynamics and highlighting the ultimate physical limit of irreversible computation.
Abstract: In 1961, Rolf Landauer argued that the erasure of information is a dissipative process. A minimal quantity of heat, proportional to the thermal energy and called the Landauer bound, is necessarily produced when a classical bit of information is deleted. A direct consequence of this logically irreversible transformation is that the entropy of the environment increases by a finite amount. Despite its fundamental importance for information theory and computer science, the erasure principle has not been verified experimentally so far, the main obstacle being the difficulty of doing single-particle experiments in the low-dissipation regime. Here we experimentally show the existence of the Landauer bound in a generic model of a one-bit memory. Using a system of a single colloidal particle trapped in a modulated double-well potential, we establish that the mean dissipated heat saturates at the Landauer bound in the limit of long erasure cycles. This result demonstrates the intimate link between information theory and thermodynamics. It further highlights the ultimate physical limit of irreversible computation.
1,019 citations
Authors
Showing all 35717 results
Name | H-index | Papers | Citations |
---|---|---|---|
Andreas Pfeiffer | 149 | 1756 | 131080 |
Nicholas A. Peppas | 141 | 825 | 90533 |
Robert H. Purcell | 139 | 666 | 70366 |
Andrea Castro | 132 | 1500 | 90019 |
Klaus Ley | 129 | 495 | 57964 |
Klaus-Robert Müller | 129 | 764 | 79391 |
Britton Chance | 128 | 1112 | 76591 |
Stefan H. E. Kaufmann | 126 | 925 | 58891 |
Thomas F. Tedder | 123 | 426 | 48374 |
Aravinda Chakravarti | 120 | 451 | 99632 |
Jerome Ritz | 120 | 644 | 47987 |
Thomas C. Quinn | 120 | 827 | 65881 |
Angela D. Friederici | 120 | 701 | 50191 |
E. K. U. Gross | 119 | 1154 | 75970 |
Alexander Rich | 115 | 539 | 50171 |