Free University of Berlin

About: Free University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Context (language use). The organization has 35195 authors who have published 66525 publications receiving 2094403 citations. The organization is also known as: FU Berlin.

QuadCover - Surface Parameterization using Branched Coverings

Abstract: We introduce an algorithm for the automatic computation of global parameterizations on arbitrary simplicial 2manifolds, whose parameter lines are guided by a given frame field, for example, by principal curvature frames. The parameter lines are globally continuous and allow a remeshing of the surface into quadrilaterals. The algorithm converts a given frame field into a single vector field on a branched covering of the 2-manifold and generates an integrable vector field by a Hodge decomposition on the covering space. Except for an optional smoothing and alignment of the initial frame field, the algorithm is fully automatic and generates high quality quadrilateral meshes.

Machine Learning for Molecular Simulation.

Abstract: Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for an ML revolution and have already been profoundly affected by the application of existing ML methods. Here we review recent ML methods for molecular simulation, with particular focus on (deep) neural networks for the prediction of quantum-mechanical energies and forces, on coarse-grained molecular dynamics, on the extraction of free energy surfaces and kinetics, and on generative network approaches to sample molecular equilibrium structures and compute thermodynamics. To explain these methods and illustrate open methodological problems, we review some important principles of molecular physics and describe how they can be incorporated into ML structures. Finally, we identify and describe a list of open challenges for the interface between ML and molecular simulation.

Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

Abstract: Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the α-subunit of the heterotrimeric G protein Gq do not aggregate and degranulate but still undergo shape change after activation through thromboxane-A2 (TXA2) or thrombin receptors. In contrast to thrombin, the TXA2 mimetic U46619 led to the selective activation of G12 and G13 in Gαq-deficient platelets indicating that these G proteins mediate TXA2 receptor-induced shape change. TXA2 receptor-mediated activation of G12/G13 resulted in tyrosine phosphorylation of pp72syk and stimulation of pp60c-src as well as in phosphorylation of myosin light chain (MLC) in Gαq-deficient platelets. Both MLC phosphorylation and shape change induced through G12/G13 in the absence of Gαq were inhibited by the C3 exoenzyme from Clostridium botulinum , by the Rho-kinase inhibitor Y-27632 and by cAMP-analogue Sp-5,6-DCl-cBIMPS. These data indicate that G12/G13 couple receptors to tyrosine kinases as well as to the Rho/Rho-kinase–mediated regulation of MLC phosphorylation. We provide evidence that G12/G13-mediated Rho/Rho-kinase–dependent regulation of MLC phosphorylation participates in receptor-induced platelet shape change.

Cassini Imaging Science: Instrument Characteristics And Anticipated Scientific Investigations At Saturn

Abstract: The Cassini Imaging Science Subsystem (ISS) is the highest-resolution two-dimensional imaging device on the Cassini Orbiter and has been designed for investigations of the bodies and phenomena found within the Saturnian planetary system. It consists of two framing cameras: a narrow angle, reflecting telescope with a 2-m focal length and a square field of view (FOV) 0.35∘ across, and a wide-angle refractor with a 0.2-m focal length and a FOV 3.5∘ across. At the heart of each camera is a charged coupled device (CCD) detector consisting of a 1024 square array of pixels, each 12 μ on a side. The data system allows many options for data collection, including choices for on-chip summing, rapid imaging and data compression. Each camera is outfitted with a large number of spectral filters which, taken together, span the electromagnetic spectrum from 200 to 1100 nm. These were chosen to address a multitude of Saturn-system scientific objectives: sounding the three-dimensional cloud structure and meteorology of the Saturn and Titan atmospheres, capturing lightning on both bodies, imaging the surfaces of Saturn’s many icy satellites, determining the structure of its enormous ring system, searching for previously undiscovered Saturnian moons (within and exterior to the rings), peering through the hazy Titan atmosphere to its yet-unexplored surface, and in general searching for temporal variability throughout the system on a variety of time scales. The ISS is also the optical navigation instrument for the Cassini mission. We describe here the capabilities and characteristics of the Cassini ISS, determined from both ground calibration data and in-flight data taken during cruise, and the Saturn-system investigations that will be conducted with it. At the time of writing, Cassini is approaching Saturn and the images returned to Earth thus far are both breathtaking and promising.