Hofstra University

About: Hofstra University is a education organization based out in Hempstead, New York, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 6341 authors who have published 11896 publications receiving 268028 citations.

Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome

Abstract: Cold-inducible RNA-binding protein (CIRP) is a damage-associated molecular pattern (DAMP) molecule which stimulates proinflammatory cytokine release in hemorrhage and sepsis. Under these medical conditions, disruption of endothelial homeostasis and barrier integrity, typically induced by proinflammatory cytokines, is an important factor contributing to morbidity and mortality. However, the role of CIRP in causing endothelial dysfunction has not been investigated. In this study, we show that intravenous injection of recombinant murine CIRP (rmCIRP) in C57BL/6 mice causes lung injury, evidenced by vascular leakage, edema, increased leukocyte infiltration and cytokine production in the lung tissue. The CIRP-induced lung damage is accompanied with endothelial cell (EC) activation marked by upregulation of cell-surface adhesion molecules E-selectin and ICAM-1. Using in vitro primary mouse lung vascular ECs (MLVECs), we demonstrate that rmCIRP treatment directly increases the ICAM-1 protein expression and activates NAD(P)H oxidase in MLVECs. Importantly, CIRP stimulates the assembly and activation of Nlrp3 inflammasome in MLVECs accompanied with caspase-1 activation, IL-1β release and induction of proinflammatory cell death pyroptosis. Finally, our study demonstrates CIRP-induced EC pyroptosis in the lungs of C57BL/6 mice for the first time. Taken together, the released CIRP in shock can directly activate ECs and induce EC pyroptosis to cause lung injury.

Focusing and Polarization in Intuitionistic Logic

Abstract: A focused proof system provides a normal form to cut-free proofs that structures the application of invertible and non-invertible inference rules. The focused proof system of Andreoli for linear logic has been applied to both the proof search and the proof normalization approaches to computation. Various proof systems in literature exhibit characteristics of focusing to one degree or another. We present a new, focused proof system for intuitionistic logic, called LJF, and show how other proof systems can be mapped into the new system by inserting logical connectives that prematurely stop focusing. We also use LJF to design a focused proof system for classical logic. Our approach to the design and analysis of these systems is based on the completeness of focusing in linear logic and on the notion of polarity that appears in Girard's LC and LU proof systems.

Sexual identity scale: A new self-assessment measure

Abstract: An individual's subjective evaluation of sexual identity differs from objective evaluation by sex role researchers. This study reports initial validity and reliability data on a new measure of self-ascribed sexual identity: the Sexual Identity Scale (SIS). SIS considers four functional sex dimensions on the basis of components described in both sex and age role literature. SIS and two modified Bem Sex Role Inventory instruments—a Masculinity Trait Index (MTI) and a Femininity Trait Index (FTI)—were administered to an adult sample of 380 men and 380 women aged 20–80. Reliability, assessed with LISREL VI and Cronbach's alpha, was found to be high. LISREL VI findings provide construct validity, both convergent and divergent. The nature of association of biological sex and sex trait measures, high interitem SIS correlations, as well as divergence from the modified sex trait indices (MTI and FTI) also support validity. The study's results and implications are discussed.