Hofstra University

About: Hofstra University is a education organization based out in Hempstead, New York, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 6341 authors who have published 11896 publications receiving 268028 citations.

Designing Effective Organizations: The Sociotechnical Systems Perspective

Abstract: The article reviews the book “Designing Effective Organizations: The Sociotechnical Systems Perspective,” by William A. Pasmore.

The Expansion Asymmetry and Age of the Cassiopeia A Supernova Remnant

Abstract: HST ACS images of the young SN remnant Cas A are used to explore the expansion and spatial distribution of its highest velocity debris. Proper motions of over 1800 outlying ejecta knots are reported. The distribution of transverse expansion velocities for these knots shows a striking bipolar asymmetry with the highest velocity knots confined to nearly opposing northeast and southwest `jets'. The jets appear kinematically and chemically distinct with respect to the remnant's highest velocity debris seen in other directions. Significant gaps in the spatial distribution of outlying ejecta lie in directions which are approximately perpendicular to the jets. Extrapolations of 9 month proper motions for all outer ejecta knots and a subsample of 72 bright and compact knots suggest explosion dates (assuming no knot deceleration) of 1662 +/- 27 and 1672 +/- 18, respectively. We find some evidence for non-uniform deceleration in different directions with knots located along the northwestern limb among the least decelerated ejecta suggesting a convergence date of 1681 +/-19. The remnant's central X-ray point source lies some $7''$ to the southeast of the estimated expansion center (PA = 169 deg) indicating a projected motion of ~350 km/s toward the middle of the broad southern outer ejecta knot gap.

The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor

Abstract: SapB is a morphogenetic peptide that is important for aerial mycelium formation by the filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial mycelium formation and depends on most of the genes known to be required for the morphogenesis of aerial hyphae. Furthermore, the application of purified SapB to mutants blocked in morphogenesis restores their capacity to form aerial hyphae. Here, we present evidence that SapB is a lantibiotic-like peptide that is derived by posttranslational modification from the product of a gene (ramS) in the four-gene ram operon, which is under the control of the regulatory gene ramR. We show that the product of another gene in the operon (ramC) contains a region that is similar to enzymes involved in the biosynthesis of lantibiotics, suggesting that it might be involved in the posttranslational processing of RamS. We conclude that SapB is derived from RamS through proteolytic cleavage and the introduction of four dehydroalanine residues and two lanthionine bridges. We provide an example of a morphogenetic role for an antibiotic-like molecule.

Detector description and performance for the first coincidence observations between LIGO and GEO

Abstract: For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.