Illinois Institute of Technology

About: Illinois Institute of Technology is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Electric power system & Wireless network. The organization has 10188 authors who have published 21062 publications receiving 554178 citations. The organization is also known as: IIT & Illinois Tech.

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Abstract: This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

Secure and practical outsourcing of linear programming in cloud computing

Abstract: Cloud computing enables customers with limited computational resources to outsource large-scale computational tasks to the cloud, where massive computational power can be easily utilized in a pay-per-use manner. However, security is the major concern that prevents the wide adoption of computation outsourcing in the cloud, especially when end-user's confidential data are processed and produced during the computation. Thus, secure outsourcing mechanisms are in great need to not only protect sensitive information by enabling computations with encrypted data, but also protect customers from malicious behaviors by validating the computation result. Such a mechanism of general secure computation outsourcing was recently shown to be feasible in theory, but to design mechanisms that are practically efficient remains a very challenging problem. Focusing on engineering computing and optimization tasks, this paper investigates secure outsourcing of widely applicable linear programming (LP) computations. In order to achieve practical efficiency, our mechanism design explicitly decomposes the LP computation outsourcing into public LP solvers running on the cloud and private LP parameters owned by the customer. The resulting flexibility allows us to explore appropriate security/efficiency tradeoff via higher-level abstraction of LP computations than the general circuit representation. In particular, by formulating private data owned by the customer for LP problem as a set of matrices and vectors, we are able to develop a set of efficient privacy-preserving problem transformation techniques, which allow customers to transform original LP problem into some random one while protecting sensitive input/output information. To validate the computation result, we further explore the fundamental duality theorem of LP computation and derive the necessary and sufficient conditions that correct result must satisfy. Such result verification mechanism is extremely efficient and incurs close-to-zero additional cost on both cloud server and customers. Extensive security analysis and experiment results show the immediate practicability of our mechanism design.