Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.
Matthew K. Tobin,Kianna Musaraca,Ahmed Disouky,Aashutosh Shetti,Abdullah Bheri,William G. Honer,Namhee Kim,Robert J. Dawe,David A. Bennett,Konstantinos Arfanakis,Konstantinos Arfanakis,Orly Lazarov +11 more
TLDR
It is demonstrated that hippocampal neurogenesis is persistent through the tenth decade of life and is detectable in patients with mild cognitive impairments and Alzheimer's disease and that it is possibly associated with cognition.About:
This article is published in Cell Stem Cell.The article was published on 2019-06-06 and is currently open access. It has received 356 citations till now. The article focuses on the topics: Neurogenesis & Neural stem cell.read more
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Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
Alana Horowitz,Xuelai Fan,Gregor Bieri,Lucas K. Smith,Cesar Sanchez-Diaz,Adam B. Schroer,Geraldine Gontier,Kaitlin B. Casaletto,Joel H. Kramer,Katherine E. Williams,Saul A. Villeda +10 more
TL;DR: A liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age is identified by identifying glycosylphosphatidylinositol-specific phospholipase D1 as a factor in plasma that might mediate this favorable effect.
Journal ArticleDOI
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease.
TL;DR: Restoration of Wnt/β-catenin signaling represents a unique opportunity for the rational design of novel AD therapies through inhibition of amyloid-β production and tau protein hyperphosphorylation.
Journal ArticleDOI
Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting
Yam Nath Paudel,Efthalia Angelopoulou,Christina Piperi,Iekhsan Othman,Khurram Aamir,Mohd Farooq Shaikh +5 more
TL;DR: The contribution of HMGB1 and its receptor signaling in neuroinflammation and AD pathogenesis is discussed, providing evidence of its beneficial effects upon therapeutic targeting.
Journal ArticleDOI
Evidences for Adult Hippocampal Neurogenesis in Humans.
Elena P. Moreno-Jiménez,Elena P. Moreno-Jiménez,Julia Terreros-Roncal,Julia Terreros-Roncal,Miguel Flor-García,Miguel Flor-García,Alberto Rábano,María Llorens-Martín,María Llorens-Martín +8 more
TL;DR: In this article, the authors highlight the critical methodological aspects that should be strictly controlled in human studies and the robust evidence that supports the occurrence of adult hippocampal neurogenesis in humans.
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Formation and integration of new neurons in the adult hippocampus
TL;DR: A review of recent advances in the field based on single-cell RNA sequencing, intravital imaging and functional observation of newborn cells in behaving mice can be found in this article.
References
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Conducting Meta-Analyses in R with the metafor Package
TL;DR: The metafor package provides functions for conducting meta-analyses in R and includes functions for fitting the meta-analytic fixed- and random-effects models and allows for the inclusion of moderators variables (study-level covariates) in these models.
Journal ArticleDOI
Neurogenesis in the adult human hippocampus
Peter S. Eriksson,Ekaterina Perfilieva,Thomas Björk-Eriksson,Ann Marie Alborn,Claes Nordborg,Daniel A. Peterson,Fred H. Gage +6 more
TL;DR: It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
Journal ArticleDOI
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures
TL;DR: Behavior, anatomical, and gene expression studies that together support a functional segmentation into three hippocampal compartments are reviewed, finding gene expression in the dorsal hippocampus correlates with cortical regions involved in information processing, while genes expressed in the ventral hippocampus correlate with regions involved with emotion and stress.
Journal ArticleDOI
Dynamics of Hippocampal Neurogenesis in Adult Humans
Kirsty L. Spalding,Olaf Bergmann,Kanar Alkass,Samuel Bernard,Mehran Salehpour,Hagen B. Huttner,Hagen B. Huttner,Emil Boström,Isabelle Westerlund,Céline Vial,Bruce A. Buchholz,Göran Possnert,Deborah C. Mash,Henrik Druid,Jonas Frisén +14 more
TL;DR: It is concluded that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.
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An autoradiographic study of the organization of the efferet connections of the hippocampal formation in the rat
Larry W. Swanson,W. M. Cowan +1 more
TL;DR: The efferent connections of the hippocampal formation of the rat have been re‐examined autoradiographically following the injection of small quantities of 3H‐amino acids into different parts of Ammon's horn and the adjoining structures to indicate quite clearly that each component of the hippocampusal formation has a distinctive pattern ofefferent connections.
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