Institution
Istanbul University
Education•Istanbul, Turkey•
About: Istanbul University is a education organization based out in Istanbul, Turkey. It is known for research contribution in the topics: Population & Medicine. The organization has 19050 authors who have published 38464 publications receiving 727640 citations. The organization is also known as: İstanbul Üniversitesi & University of Istanbul.
Topics: Population, Medicine, Cancer, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: In this article, the effect of the compatibilizers on the clay dispersion and clay amount on the microstructure and physical properties of the nanocomposites were investigated.
300 citations
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TL;DR: In this paper, the authors present a comprehensive study of spectroscopic radius measurements of twelve neutron stars obtained during thermonuclear bursts or in quiescence, incorporating uncertainties in the measurement of the apparent angular sizes, Eddington fluxes, and distances, in the composition of the interstellar medium, and in the flux calibration of X-ray detectors.
Abstract: We present a comprehensive study of spectroscopic radius measurements of twelve neutron stars obtained during thermonuclear bursts or in quiescence. We incorporate, for the first time, a large number of systematic uncertainties in the measurement of the apparent angular sizes, Eddington fluxes, and distances, in the composition of the interstellar medium, and in the flux calibration of X-ray detectors. We also take into account the results of recent theoretical calculations of rotational effects on neutron star radii, of atmospheric effects on surface spectra, and of relativistic corrections to the Eddington critical flux. We employ Bayesian statistical frameworks to obtain neutron star radii from the spectroscopic measurements as well as to infer the equation of state from the radius measurements. Combining these with the results of experiments in the vicinity of nuclear saturation density and the observations of ∼ 2 M⊙ neutron stars, we place strong and quantitative constraints on the properties of the equation of state between ≈ 2 − 8 times the nuclear saturation density. We find that around M = 1.5 M⊙, the preferred equation of state predicts a radius of 10.8 +0.5 −0.4 km. When interpreting the pressure constraints in the context of high density equations of state based on interacting nucleons, our results suggest a weaker contribution of the three-body interaction potential than previously considered. Subject headings: dense matter — equation of state — stars:neutron — X-rays:stars — X-rays:bursts — X-rays:binaries
299 citations
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University of Manchester1, Kansai Medical University2, Institut Gustave Roussy3, Complutense University of Madrid4, Katholieke Universiteit Leuven5, Sarah Cannon Research Institute6, VU University Amsterdam7, Johns Hopkins University8, Memorial Sloan Kettering Cancer Center9, Peking Union Medical College10, Istanbul University11, Chungbuk National University12, Yonsei University13, AstraZeneca14
TL;DR: These updated, exploratory analyses demonstrate durable PFS and sustained OS benefit with durvalumab following CRT, and are consistent with the primary analyses.
299 citations
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Goethe University Frankfurt1, University of York2, University of Toronto3, Boston Children's Hospital4, Federal University of São Paulo5, University of Pennsylvania6, University of Chile7, Istituto Giannina Gaslini8, London South Bank University9, University of Münster10, All India Institute of Medical Sciences11, Istanbul University12, Duke University13
TL;DR: This guideline represents an evidence-based approach to FN specific to children with cancer, and although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas.
Abstract: Purpose To develop an evidence-based guideline for the empiric management of pediatric fever and neutropenia (FN). Methods The International Pediatric Fever and Neutropenia Guideline Panel is a multidisciplinary and multinational group composed of experts in pediatric oncology and infectious disease as well as a patient advocate. The Panel was convened for the purpose of creating this guideline. We followed previously validated procedures for creating evidence-based guidelines. Working groups focused on initial presentation, ongoing management, and empiric antifungal therapy. Each working group developed key clinical questions, conducted systematic reviews of the published literature, and compiled evidence summaries. The Grades of Recommendation Assessment, Development, and Evaluation approach was used to generate summaries, and evidence was classified as high, moderate, low, or very low based on methodologic considerations. Results Recommendations were made related to initial presentation (risk stratification, initial evaluation, and treatment), ongoing management (modification and cessation of empiric antibiotics), and empiric antifungal treatment (risk stratification, evaluation, and treatment) of pediatric FN. For each recommendation, the strength of the recommendation and level of evidence are presented. Conclusion This guideline represents an evidence-based approach to FN specific to children with cancer. Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas. Implementation will require adaptation to the local context.
299 citations
Authors
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Name | H-index | Papers | Citations |
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Bobby Samir Acharya | 133 | 1121 | 100545 |
Serkant Ali Cetin | 129 | 1369 | 85175 |
Alexander Nikitenko | 129 | 1159 | 82102 |
Aytul Adiguzel | 124 | 964 | 71366 |
Neil Risch | 122 | 386 | 70042 |
Laurent Poirel | 117 | 621 | 53680 |
Andrei Starodumov | 114 | 697 | 57900 |
Suat Ozkorucuklu | 110 | 698 | 55607 |
Robert J. Desnick | 102 | 694 | 39698 |
Lars Berglund | 97 | 641 | 42300 |
Angel Carracedo | 88 | 885 | 38053 |
Peter A. Merkel | 85 | 430 | 34014 |
Thomas A. Pearson | 84 | 349 | 41573 |
Willy Malaisse | 80 | 1635 | 31641 |
C. Pagliarone | 79 | 796 | 27164 |