Institution
Istanbul University
Education•Istanbul, Turkey•
About: Istanbul University is a education organization based out in Istanbul, Turkey. It is known for research contribution in the topics: Population & Medicine. The organization has 19050 authors who have published 38464 publications receiving 727640 citations. The organization is also known as: İstanbul Üniversitesi & University of Istanbul.
Topics: Population, Medicine, Cancer, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that in a significant proportion of type 2 diabetic patients who fail to respond to dietary measures, short-term intensive insulin treatment can effectively establish responsiveness, allowing long-term glycemic control without medication.
Abstract: OBJECTIVE Type 2 diabetes is a slowly progressive disease, in which the gradual deterioration of glucose tolerance is associated with the progressive decrease in β-cell function. Hyperglycemia per se has deleterious effects on both beta-cell function and insulin action, which are partially reversible by the short-term control of blood glucose levels. We hypothesized that the induction of euglycemia, using intensive insulin therapy at the time of clinical diagnosis, could lead to a significant improvement in insulin secretion and action and thus alter the clinical course of the disease. RESEARCH DESIGN AND METHODS Thirteen newly diagnosed diet-unresponsive type 2 diabetic patients were treated with continuous subcutaneous insulin infusion (CSII) for 2 weeks and followed longitudinally while being treated with diet alone. RESULTS Four patients were considered therapeutic failures since CSII failed to induce euglycemia ( n = 1) or glucose control deteriorated within 6 months after CSII ( n = 3). The remaining nine patients were maintained on diet alone with adequate control from 9 to > 50 months (median ± SE, 26 ± 4.8 months). In five patients, glycemic control deteriorated after 9–36 months, but a repeat 2-week CSII treatment reestablished control in four patients. One of these patients underwent a third CSII treatment 13 months later. At the time this article was written, six patients of the initial group were still controlled without medication 16–59 months (median ± SE, 45.5 ± 6.6 months) after the initiation of treatment. Body weight remained unchanged in all patients. CONCLUSIONS These findings suggest that in a significant proportion of type 2 diabetic patients who fail to respond to dietary measures, short-term intensive insulin treatment can effectively establish responsiveness, allowing long-term glycemic control without medication. Further studies are required to establish whether simpler treatment regimens could be equally effective. If the hypothesis offered here finds support, present approaches to the management of newly diagnosed type 2 diabetes may need to be revised.
269 citations
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Population Health Research Institute1, The George Institute for Global Health2, Ottawa Hospital Research Institute3, University of London4, University of North Carolina at Chapel Hill5, Birzeit University6, Loyola University Chicago7, Simon Fraser University8, St. John's Medical College9, Post Graduate Institute of Medical Education and Research10, North-West University11, University of the Western Cape12, Isfahan University of Medical Sciences13, Independent University, Bangladesh14, Sahlgrenska University Hospital15, University Kebangsaan Malaysia Medical Centre16, Dubai Health Authority17, Istanbul University18, Aga Khan University19, College of Health Sciences, Bahrain20, University of La Frontera21, Universiti Teknologi MARA22, Laval University23
TL;DR: In this article, the authors assessed fruit and vegetable consumption using data from country-specific, validated semi-quantitative food frequency questionnaires in the Prospective Urban Rural Epidemiology (PURE) study, which enrolled participants from communities in 18 countries between Jan 1, 2003, and Dec 31, 2013.
268 citations
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TL;DR: This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide and identifies similar 70-kb plasmids carrying the blaOXA- 48 gene.
Abstract: Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla(OXA-48) were identified. That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide.
268 citations
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University of Bonn1, University of Rochester2, Temple University3, Case Western Reserve University4, Paris Diderot University5, Istanbul University6, University of Alabama at Birmingham7, King's College London8, University of Hong Kong9, The Forsyth Institute10, Columbia University11, National and Kapodistrian University of Athens12, Dalhousie University13, University of Texas Health Science Center at San Antonio14, Newcastle University15, University of Maryland, Baltimore16, University of Bern17, Georgia Regents University18, University of Bristol19, Niigata University20
TL;DR: An updated classification of theperiodontal manifestations and conditions affecting the course of periodontitis and the periodontal attachment apparatus, as well as of developmental and acquired conditions, is introduced.
266 citations
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Paris Diderot University1, Yonsei University2, Drexel University3, Kyungpook National University Hospital4, Kaohsiung Medical University5, National University of Singapore6, Istanbul University7, University of Hamburg8, Queen Mary University of London9, Toronto General Hospital10, Royal Prince Alfred Hospital11, Carlos III Health Institute12, Seconda Università degli Studi di Napoli13, Alice Ho Miu Ling Nethersole Hospital14, Athens State University15, Medical University of Białystok16, The Chinese University of Hong Kong17
TL;DR: A significantly greater proportion of patients received TDF plus peginterferon for 48 weeks had HBsAg loss than those receiving TDF or peginerferon alone.
266 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
Bobby Samir Acharya | 133 | 1121 | 100545 |
Serkant Ali Cetin | 129 | 1369 | 85175 |
Alexander Nikitenko | 129 | 1159 | 82102 |
Aytul Adiguzel | 124 | 964 | 71366 |
Neil Risch | 122 | 386 | 70042 |
Laurent Poirel | 117 | 621 | 53680 |
Andrei Starodumov | 114 | 697 | 57900 |
Suat Ozkorucuklu | 110 | 698 | 55607 |
Robert J. Desnick | 102 | 694 | 39698 |
Lars Berglund | 97 | 641 | 42300 |
Angel Carracedo | 88 | 885 | 38053 |
Peter A. Merkel | 85 | 430 | 34014 |
Thomas A. Pearson | 84 | 349 | 41573 |
Willy Malaisse | 80 | 1635 | 31641 |
C. Pagliarone | 79 | 796 | 27164 |