Medical University of Varna

About: Medical University of Varna is a education organization based out in Varna, Varna, Bulgaria. It is known for research contribution in the topics: Population & Medicine. The organization has 1199 authors who have published 1273 publications receiving 32940 citations. The organization is also known as: MU-Varna & Higher Medical Institute of Varna.

Evaluation of potential drug-drug interactions in psychiatric patients: a pilot study

Abstract: Introduction: Drug-drug interactions (DDIs) are common but avoidable causes for adverse drug reactions. Aim: The present pilot study aimed to assess the prevalence of potential DDIs (pDDIs) among patients with psychiatric disorders by evaluation of patients` hospital records and their discharge medication lists. Materials and Methods: A retrospective review of medication information was conducted for 47 male patients consecutively admitted for a period of one month to the acute unit of a university-based psychiatric clinic. Potential DDIs were checked with Medscape drug interaction checker and standard references on drug interactions, and were classified as major, moderate, or minor according to their severity. The statistical analysis included: Chi-square test, Student`s t-test, and correlation analysis. Results: For the duration of the hospitalization a total of 121 interacting drug pairs were detected, potentially capable of inducing DDIs (2.57 per patient). Out of all the patients 44 (94 %) were exposed to at least one pDDI and 7 (15%) to at least one serious pDDI. The most common potential risk was the additive sedative effect, involving 58 drug pairs with an average rate of 1.23 per patient. QTc prolonging drug combinations were found in 11 (23%) patients, drug combinations with potential risk of hematologic toxicity in 10 (21%) patients and such with potential risk of hepatic/metabolic toxicity in 9 (19%). CYP-mediated pDDIs were identified in 8 (17%) patients. At hospital discharge fewer pDDIs per patient (1.13) were detected. Conclusion: A high prevalence of pDDIs among the psychiatric inpatients was recorded. Caution is warranted to limit the exposure of the patients to pDDIs.

Influence of the oral mucosa condition on the nutritional status of children with neurological impairment in Varna

Abstract: Introduction : The assessment of the causes for malnutrition in children with neurological impairment (NI) in Bulgaria is challenging due to the heterogeneity of the leading diagnosis. In the case of soreness of the oral mucosa due to inflammatory processes or mechanical irritation, children experience discomfort and this disrupts the normal course of chewing. So far, no association between undernutrition in children with NI and the condition of the oral mucosa has been examined in Bulgaria. Aim : The aim of this article is to evaluate the condition of the oral mucosa and its relationship to the nutritional status of children with NI. Material s and Methods : About 54 patients with NI were recruited for the study, which took place between April and October 2017. Twenty-five of them lived in family settings and 29 in residential care (RC) in Varna, Bulgaria. After briefing all participants (family members and caretakers) about the nature and meaning of the study, they took an informed participation in an intraoral examination of the oral cavity of their children. The nutritional status was assessed by anthropometric measurements. The study was approved by the Medical Ethical Committee of the Medical University of Varna. Results: The examination of the condition of the oral mucosa of children with NI revealed various signs of inflammatory changes of the mucous membranes, showing that among 66% of the recruited patients redness and swelling, lining on the back of the tongue, etc. were observed. There were various inflammatory changes observed in the oral mucosa in 89.28% of the cases who are raised in the RC and 40% in those living in family settings. The differences in the prevalence of inflammatory changes of the oral mucosa between the two groups of patients was statistically significant ( X 2 = 16.13, p = 0.001). Statistically significant was also the relationship between the oral mucosal status and the status of malnutrition, as estimated by anthropometric indicators such as weight-for-age, height-for-age and subscapular skin fold thickness following the World Health Organization criteria and standards (2006, 2007). Discussion: Many factors affect malnutrition in children with NI. One of the factors is the condition of the oral mucosa. Its improvement would most probably increase the ability of this vulnerable group of children to eat foods of varying composition and consistency, which would have a positive effect on their nutritional status. Conclusion: Our study shows a direct link between inflamed and painful oral mucosa and malnutrition in children with NI.

Intravenous lipid infusion in toxicological practice

Abstract: The use of intravenous lipid emulsions (ILEs) is a relatively new method of treatment in toxicology. Initially, it was applied to control the resistant to other therapeutic methods systemic toxicity of local anesthetics. In the last decade this therapeutic method has been approved and recommended. Thereafter, attempts have been made to clarify the effect of ILEs in cases of acute intoxications with lipophilic xenobiotics, other than the local anesthetics.

Experimental Validating of Reliability Model of MOSFETs in Resonant Full Bridge Inverter

Abstract: This paper concerns a comparison between experimental results and theoretical model of MOSFETs reliability in resonant full bridge inverter. The experimental data is obtained with five different resonant load circuits. The experimental and theoretical results are presented in tabular and graphical form as well. Also some thermal images of the power circuit of the inverter in studied cases are shown.

The good microclimate in the dental laboratory as a prerequisite for successful

Abstract: За постигането на добър микроклимат в зъботехническата лаборатория е необходимо да се акцентира на успешната комуникация, на обратната връзка, на разбирателството, на позитивните чувства. Управителят трябва да опознае хората от екипа си като професионалисти и личности. Трябва да разбере как мислят, какво ги мотивира и ангажира, за да полагат максимални усилия. Установяването и поддържането на двустранна комуникация (между мениджърите и хората в организацията) трябва да стимулира достойнствата, да мотивира постиженията и да установява взаимно доверие и съгласие. Проучено е мнението на управители на зъботехнически лаборатории и работещите в тях зъботехници относно необходимостта от поддържане на добър микроклимат в лабораторията. Проведено е анкетно проучване през месеците ноември/декември 2014 г. Обект на изследване са 47 респонденти (17 управители на зъботехнически лаборатории и 30 зъботехници, работещи като наемни служители). Използвани са социологически, статистически методи и графичен анализ. Според резултатите важни за добрия микроклимат са уважението между колегите (управители 33.30%, зъботехници 70.00%) и между колегите и управителя (управители 40.30%, зъботехници 50.00%). Управителите смятат, че правят всичко необходимо, за да решат проблема (66.70%), но според повече от половината анкетирани зъботехници се търси предимно компромисно решение (56.70%). Допълнително обучение по здравен мениджмънт би помогнало на управителите за подобряване на микроклимата, поддържане мотивацията на служителите с цел по-успешна практика.