Medical University of Varna

About: Medical University of Varna is a education organization based out in Varna, Varna, Bulgaria. It is known for research contribution in the topics: Population & Medicine. The organization has 1199 authors who have published 1273 publications receiving 32940 citations. The organization is also known as: MU-Varna & Higher Medical Institute of Varna.

Electrocution-related mortality: a review of 351 deaths by low-voltage electrical current.

Abstract: BACKGROUND: We describe herein the characteristics of lethal injuries caused by low-voltage electrical current (electrocution), the most frequent injury caused by electrical current. METHODS: Nine hundred forty-five cases over a period of 41 years (1965-2006) were reviewed, of which, 351 electrocution cases were identified. The descriptive statistical analyses were carried out with the application of SPSS 11.0 software. RESULTS: Electrocution accounted for 37.14% of all studied electricity-caused injuries. The average age of the victims was 35.25 years. The average age of male victims was 36.19 years and of female victims was 32.55 years. The distribution by gender showed a significant prevalence of the male sex (74.07%). Among the circumstances leading to electrocution, household accidents (78.06%) prevailed over occupational accidents (13.39%). Suicides were significantly rarer (7.41%). 66.10% of all electrocution cases occurred during the summer period from June through September. CONCLUSION: Household accidents prevail among the circumstances under which electrocution occurs, with an insignificant difference in the male/female proportion in this group. The majority of electrocutions occurred during the summer period (June-September). The results obtained in this research can help in the development of a differentiated strategy for the prevention of electrocution, while taking into consideration gender, age and season of the year. Language: en

Understanding the needs of professionals who provide psychosocial care for children and adults with disorders of sex development.

Abstract: Objective Disorders in sex development (DSD) can be treated well medically, but families will encounter many psychosocial challenges. Promoting counselling to facilitate acceptance and coping is important yet equality of access is unknown. This study investigated the modalities of psychosocial care provided in centres of DSD care. Methods An international survey conducted among 93 providers of psychosocial care, identified through clinical networks, registries and professional forums. Results Forty-six respondents from 22 different countries filled out the survey (49%). Most respondents (78%) were based in hospital-based expert teams. Referrals came from paediatric endocrinologists (76%), gynaecologists (39%) and paediatric urologists (37%). Psychological counselling was most frequently given to parents (74%), followed by children (39%), adolescents (37%) and adults (11%) and was most frequently focused on coping and acceptance of DSD (54%), education (52%), the atypical body (39%) and genital (41%), decisions on genital surgery (33%), complications with sexual intercourse (29%), disclosure (28%) and acceptance of infertility (11%). Respondents most frequently observed DSD related confusion about gender (54%), acceptance of cross gender behaviour (50%), anxiety (43%) and sadness and depression (38%). Conclusions Most psychosocial care is provided to parents. It is assumed that parental support is important as acceptance is conditional to become affectionate caretakers. Although it may be more difficult for youngsters to communicate about their condition and treatment, providing opportunity to bring up issues that are important for them, is imperative. Clinicians and parents should be aware that parental and patients’ interests may not correspond completely. Psychosocial management should also include transition and adult care.

Forensic Characteristics of Suicide by Electrocution in Bulgaria

Abstract: Suicides by electrocution (SE) are relatively rare and insufficiently studied. The purpose of this study is to present a more detailed picture of SE in Bulgaria. Forensic medical files of 59 SE cases were examined. SPSS 11.0 software was applied to produce the descriptive statistical analyses. Values of p 220 V). The preferred method of SE was by direct contact victim/electrical cable: 47.45%. The summer months June through September account for 49.15% of all cases.

The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes.

Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and a wide spectrum of manifestations ranging from indolent and asymptomatic cytopenias to acute myeloid leukemia (AML). MDS result from genetic and epigenetic derangements in clonal cells and their surrounding microenvironments. Studies have shown associations between MDS and other autoimmune diseases. Several immune mechanisms have been identified in MDS, suggesting that immune dysregulation might be at least partially implicated in its pathogenesis. This has led to rigorous investigations on the role of immunomodulatory drugs as potential treatment options. Epigenetic modification via immune check point inhibition, while well established as a treatment method for advanced solid tumors, is a new approach being considered in hematologic malignancies including high risk MDS. Several trials are looking at the efficacy of these agents in MDS, as frontline therapy and in relapse, both as monotherapy and in combination with other drugs. In this review, we explore the utility of immune checkpoint inhibitors in MDS and current research evaluating their efficacy.