Novozymes

About: Novozymes is a company organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Nucleic acid & Polynucleotide. The organization has 2506 authors who have published 2828 publications receiving 89266 citations. The organization is also known as: Novo Enzymes A/S & Novozymes A/S.

A bacillus promoter derived from a variant of a bacillus licheniformis x-amylase promoter

Abstract: A Bacillus promoter included in DNA sequence (SEQ ID#1), wherein each of N1-N9 is A, T, C or G with the exception that N2-N9 do not together form the sequence ATGTTTCA or GTGTTTCA, or a functional homologue of said sequence.

In vitro Toxicity Testing in the Twenty-First Century.

Abstract: The National Research Council (NRC) article “Toxicity Testing in the 21st Century: A vision and A Strategy” (National Research Council, 2007) was written to bring attention to the application of scientific advances for use in toxicity tests so that chemicals can be tested in a more time and cost efficient manner while providing a more relevant and mechanistic insight into the toxic potential of a compound. Development of tools for in vitro toxicity testing constitutes an important activity of this vision and contributes to the provision of test systems as well as data that are essential for the development of computer modelling tools for e.g. system biology, physiologically-based modelling. This article intends to highlight some of the issues that have to be addressed in order to make in vitro toxicity testing a reality in the 21st century.

Atomic resolution structure of endoglucanase Cel5A in complex with methyl 4,4II,4III,4IV-tetrathio-α-cellopentoside highlights the alternative binding modes targeted by substrate mimics

Abstract: Many three-dimensional structures of retaining β-d-glycoside hydrolases have been determined, yet oligosaccharide complexes in which the ligand spans the catalytic centre are rare. Those that have been reported so far have revealed two modes of binding: those in which the substrate adopts a distorted skew-boat or envelope conformation in the −1 subsite, reflecting the distortion observed during the catalytic cycle, and those which bypass the true catalytic centre and thus lie in a non-productive manner across the −1 subsite. The three-dimensional structure of a retaining endocellulase, Bacillus agaradhaerens Cel5A, in complex with methyl 4,4II,4III,4IV-tetrathio-α-cellopentoside falls into this latter category. The 1.1 A structure reveals the binding of five pyranosides, all in the 4C1 chair conformation, occupying the −3, −2, +1 and +2 subsites whilst evading the catalytic machinery located in the true −1 subsite. Such binding is in marked contrast to the structure of another retaining endocellulase, the Fusarium oxysporum Cel7B, the identical ligand in which displayed a distorted skew-boat conformation at the active centre. These two binding modes may reflect different steps in the binding and catalytic process.

Bacteria Cultures and Compositions Comprising Bacteria Cultures

Abstract: The present invention relates to bacteria cultures and composition comprising one or more cultures of the invention. The invention also relates to methods of washing or cleaning laundry or fabrics and surfaces as well as degrading waste material using a bacteria culture of the invention.

Novel glycoside hydrolases from thermophilic fungi

Abstract: The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.