Institution
RAND Corporation
Nonprofit•Santa Monica, California, United States•
About: RAND Corporation is a nonprofit organization based out in Santa Monica, California, United States. It is known for research contribution in the topics: Health care & Population. The organization has 9602 authors who have published 18570 publications receiving 744658 citations.
Topics: Health care, Population, Poison control, Public health, Mental health
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, the authors used a military data set to confirm that expected length of stay in a dwelling and the transaction costs of selling are very important to the ownership decision and their best estimate of the transaction cost of selling a home are the sum of 3% of house value and 4% of household earnings.
162 citations
••
TL;DR: A working meeting on content validity was convened with leading PRO measurement experts, highlighting key issues in the content validity debate, including inconsistency in the definition and evaluation of content validity, the need for empirical research to support methodological approaches to the evaluation ofcontent validity, and concerns that continual re-evaluation of content validation slows the pace of science.
Abstract: Content validity of patient-reported outcome measures (PROs) has been a focus of debate since the 2006 publication of the U.S. FDA Draft Guidance for Industry in Patient Reported Outcome Measurement. Under the auspices of the Patient Reported Outcomes Measurement Information System (PROMIS) initiative, a working meeting on content validity was convened with leading PRO measurement experts. Platform presentations and participant discussion highlighted key issues in the content validity debate, including inconsistency in the definition and evaluation of content validity, the need for empirical research to support methodological approaches to the evaluation of content validity, and concerns that continual re-evaluation of content validity slows the pace of science and leads to the proliferation of study-specific PROs. We advocate an approach to the evaluation of content validity, which includes meticulously documented qualitative and advanced quantitative methods. To advance the science of content validity in PROs, we recommend (1) development of a consensus definition of content validity; (2) development of content validity guidelines that delineate the role of qualitative and quantitative methods and the integration of multiple perspectives; (3) empirical evaluation of generalizability of content validity across applications; and (4) use of generic measures as the foundation for PROs assessment.
162 citations
••
TL;DR: The benefits and requirements of collaborative care models, where non-communicable disease and mental health care are integrated and provided in the primary care setting, are discussed.
Abstract: In the third article of a five-part series providing a global perspective on integrating mental health, Victoria Ngo and colleagues discuss the benefits and requirements of collaborative care models, where non-communicable disease and mental health care are integrated and provided in the primary care setting. Please see later in the article for the Editors' Summary
162 citations
••
TL;DR: An alternative to the dominant contemporary tendency to define translational research in terms of a series of discrete “phases” is offered, arguing for the identification of key operational and measurable markers along a generalized process pathway from research to practice.
Abstract: The concept of translational research has become critically important in contemporary biomedical research and practice. It is the subject of a rapidly growing literature, catching the attention of most leading biomedical journals and becoming the central focus of several new publications. Translational research is showing up in everything from research grant proposals to the curricula of leading medical schools and schools of public health. It is the focus of considerable effort in the biomedical industry (Birmingham, 2002) and is increasingly central to discussions of public health. The National Institutes of Health have made it a central priority, part of their “Roadmap” initiative. One of their primary programs, the Clinical and Translational Science Awards (CTSA), currently expends over $350 million per year to fund 55 research centers and by 2012 is expected to fund 60 centers at a cost of approximately a half billion dollars per year, making it the largest program at NIH.
What is behind this considerable investment in translational research? One of the most significant motivations comes from a relatively small number of studies that show that it takes a long time to move basic scientific ideas to practice and health impacts. For instance, Westfall, Mold and Fagnon (2007) asserted that “It takes an estimated average of 17 years for only 14% of new scientific discoveries to enter day-to-day clinical practice” (p. 403). They based their claim on earlier work (Balas & Boren, 2000) that similarly stated “Studies suggest that it takes an average of 17 years for research evidence to reach clinical practice” (p.66) at a rate of 50% use in the relevant population. Other work (Contopoulos-Ioannidis, Alexiou, Gouvias, & Ioannidis, 2008) suggests that the median translation lag was 24 years between first description and earliest highly cited article. Because these studies typically only measure part of the process of moving from research to practice and eventually to health outcomes and impacts, these are likely to be significant underestimates. Translational research in many ways can trace its primary impetus to the notion that this time lag is seen as too long, certainly longer than necessary, and that there must be a better way to move research to practice more quickly without sacrificing quality or increasing costs. Proposed solutions include everything from better management of scientific research and increased process efficiency to wholesale rethinking of the biomedical research-practice endeavor for the 21st century.
This paper focuses on the length of time that translational research takes. We do so because the long duration and time estimates to move research to practice were critical to making the policy case for significant investments in translational research. Nevertheless, temporality and duration concerns need to be considered in the context of many other factors including quality of research, cost, ethics, management, potential impacts, and so on (Rubio et al., 2010). The success of the translational research endeavor will ultimately be judged by whether it reduces the time and duration issue while at least preserving the current status of other factors like quality or cost.
We argue here that one of the major tasks for evaluators involved in translational research is to help assess whether efforts like the CTSAs can reduce the time it takes to move research to practice and health impacts and increase the rate and volume of translation -- all while ensuring the quality and cost-efficiency of the conduct of research. This paper examines the concept of translational research from the perspective of evaluators charged with assessing translational efforts. In doing so we hope to: a) consider the most prominent models of translational research that have been offered in the literature, b) synthesize the major features that are shared across these models in order to show underlying commonalities, and c) suggest a new synthetic framework for evaluating progress in enhancing research translation that is consistent with existing models but avoids some of the major current problems. Specifically, we offer here an alternative to the dominant contemporary tendency to define translational research in terms of a series of discrete “phases.” We contend that this phased approach is insufficiently precise for most evaluation purposes and instead argue for the identification of key operational and measureable markers along a generalized process pathway from research to practice.
162 citations
••
TL;DR: In this paper, the authors considered the concept of risk differentials in corporate profit and proposed a model for measuring them, using this model, the risk-rate of return relationship was estimated for a sample of firms in various industry groups.
Abstract: : Although economists have great interest in the correlation between risk and profits, few studies have attempted to quantify the relationship. Consequently, this paper considers the concept of risk differentials in corporate profit and proposes a model for measuring them. Using this model, the risk-rate of return relationship was estimated for a sample of firms in various industry groups. For each industry group, average risk-adjusted rates of return were also obtained.
162 citations
Authors
Showing all 9660 results
Name | H-index | Papers | Citations |
---|---|---|---|
Darien Wood | 160 | 2174 | 136596 |
Herbert A. Simon | 157 | 745 | 194597 |
Ron D. Hays | 135 | 781 | 82285 |
Paul G. Shekelle | 132 | 601 | 101639 |
John E. Ware | 121 | 327 | 134031 |
Linda Darling-Hammond | 109 | 374 | 59518 |
Robert H. Brook | 105 | 571 | 43743 |
Clifford Y. Ko | 104 | 514 | 37029 |
Lotfi A. Zadeh | 104 | 331 | 148857 |
Claudio Ronco | 102 | 1312 | 72828 |
Joseph P. Newhouse | 101 | 484 | 47711 |
Kenneth B. Wells | 100 | 484 | 47479 |
Moyses Szklo | 99 | 428 | 47487 |
Alan M. Zaslavsky | 98 | 444 | 58335 |
Graham J. Hutchings | 97 | 995 | 44270 |