Institution
Seoul National University
Education•Seoul, South Korea•
About: Seoul National University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 65879 authors who have published 138759 publications receiving 3715170 citations. The organization is also known as: SNU & Seoul-dae.
Topics: Population, Catalysis, Thin film, Gene, Cancer
Papers published on a yearly basis
Papers
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TL;DR: An essential role of DROSHA is demonstrated and an important contribution of DICER in the canonical miRNA pathway is revealed, and the function of XPO5 can be complemented by alternative mechanisms.
Abstract: Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of each of these maturation steps, we deleted DROSHA, XPO5, and DICER in the same human cell line, and analyzed their effects on miRNA biogenesis. Canonical miRNA production was completely abolished in DROSHA-deleted cells, whereas we detected a few DROSHA-independent miRNAs including three previously unidentified noncanonical miRNAs (miR-7706, miR-3615, and miR-1254). In contrast to DROSHA knockout, many canonical miRNAs were still detected without DICER albeit at markedly reduced levels. In the absence of DICER, pre-miRNAs are loaded directly onto AGO and trimmed at the 3′ end, yielding miRNAs from the 5′ strand (5p miRNAs). Interestingly, in XPO5 knockout cells, most miRNAs are affected only modestly, suggesting that XPO5 is necessary but not critical for miRNA maturation. Our study demonstrates an essential role of DROSHA and an important contribution of DICER in the canonical miRNA pathway, and reveals that the function of XPO5 can be complemented by alternative mechanisms. Thus, this study allows us to understand differential contributions of key biogenesis factors, and provides with valuable resources for miRNA research.
383 citations
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Uppsala University1, International School for Advanced Studies2, Imperial College London3, University of California, Davis4, Perimeter Institute for Theoretical Physics5, Harvard University6, National Taiwan University7, Seoul National University8, Korea Institute for Advanced Study9, Princeton University10, University of Geneva11, University of California, Santa Barbara12, University of Milan13, Max Planck Society14, C. N. Yang Institute for Theoretical Physics15, Technion – Israel Institute of Technology16, Institute for the Physics and Mathematics of the Universe17, Royal Institute of Technology18
TL;DR: In this paper, a special issue on localization techniques in quantum field theory is presented, where a summary of individual chapters is given and their interrelation is discussed, as well as their interrelationships among them.
Abstract: This is the foreword to the special issue on localization techniques in quantum field theory. The summary of individual chapters is given and their interrelation is discussed.
383 citations
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University of Toronto1, Enel2, Beijing Normal University3, TERI University4, De La Salle University5, Seoul National University6, Federal University of Rio de Janeiro7, University of California, Los Angeles8, Imperial College London9, University of Paris10, Trisakti University11, University of Lagos12, University of Tehran13, Bangladesh University of Engineering and Technology14, Hunter College15, United States Environmental Protection Agency16, NED University of Engineering and Technology17, Universidad de Guanajuato18, Istanbul Technical University19
TL;DR: The quantification of energy and material flows for the world’s 27 megacities with populations greater than 10 million people as of 2010 is a major undertaking, not previously achieved and largely consistent with scaling laws established in the emerging science of cities.
Abstract: Understanding the drivers of energy and material flows of cities is important for addressing global environmental challenges. Accessing, sharing, and managing energy and material resources is particularly critical for megacities, which face enormous social stresses because of their sheer size and complexity. Here we quantify the energy and material flows through the world’s 27 megacities with populations greater than 10 million people as of 2010. Collectively the resource flows through megacities are largely consistent with scaling laws established in the emerging science of cities. Correlations are established for electricity consumption, heating and industrial fuel use, ground transportation energy use, water consumption, waste generation, and steel production in terms of heating-degree-days, urban form, economic activity, and population growth. The results help identify megacities exhibiting high and low levels of consumption and those making efficient use of resources. The correlation between per capita electricity use and urbanized area per capita is shown to be a consequence of gross building floor area per capita, which is found to increase for lower-density cities. Many of the megacities are growing rapidly in population but are growing even faster in terms of gross domestic product (GDP) and energy use. In the decade from 2001–2011, electricity use and ground transportation fuel use in megacities grew at approximately half the rate of GDP growth.
383 citations
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TL;DR: TAIL-seq is a potent tool to dissect dynamic control of mRNA turnover and translational control, and to discover unforeseen features of RNA cleavage and tailing, including widespread uridylation and guanylation at the downstream of poly(A) tail.
383 citations
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TL;DR: In this article, the authors synthesized monodisperse Pd nanoparticles with particle sizes of 3.5, 5, and 7 nm from the thermal decomposition of a Pd−surfactant complex.
Abstract: We have synthesized monodisperse Pd nanoparticles with particle sizes of 3.5, 5, and 7 nm from the thermal decomposition of a Pd−surfactant complex. The particle size of Pd nanoparticles was controlled by varying the concentration of stabilizing surfactant.
383 citations
Authors
Showing all 66324 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Adi F. Gazdar | 157 | 776 | 104116 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Yongsun Kim | 156 | 2588 | 145619 |
David J. Mooney | 156 | 695 | 94172 |
Roberto Romero | 151 | 1516 | 108321 |
Jongmin Lee | 150 | 2257 | 134772 |
Byung-Sik Hong | 146 | 1557 | 105696 |
Inkyu Park | 144 | 1767 | 109433 |
Teruki Kamon | 142 | 2034 | 115633 |
John L. Hopper | 140 | 1229 | 86392 |
Ali Khademhosseini | 140 | 887 | 76430 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Suyong Choi | 135 | 1495 | 97053 |
Intae Yu | 134 | 1372 | 89870 |