Seoul National University

About: Seoul National University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 65879 authors who have published 138759 publications receiving 3715170 citations. The organization is also known as: SNU & Seoul-dae.

Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer

Abstract: Purpose: To evaluate the expression of stem cell–related markers at the cellular level in human breast tumors of different subtypes and histologic stage Experimental Design: We performed immunohistochemical analyses of 12 proteins [CD44, CD24, ALDH1, vimentin, osteonectin, EPCR, caveolin 1, connexin 43, cytokeratin 18 (CK18), MUC1, claudin 7, and GATA3] selected based on their differential expression in breast cancer cells with more differentiated and stem cell–like characteristics in 47 cases of invasive ductal carcinoma (IDC) only, 135 cases of IDC with ductal carcinoma in situ (DCIS), 35 cases of DCIS with microinvasion, and 58 cases of pure DCIS We also analyzed 73 IDCs with adjacent DCIS to determine the differences in the expression of markers by histology within individual tumors CD44+/CD24− and CD24−/CD24+ cells were detected using double immunohistochemistry Results: CD44 and EPCR expression was different among the four histologic groups and was lower in invasive compared with in situ tumors, especially in luminal A subtype The expression of vimentin, osteonectin, connexin 43, ALDH1, CK18, GATA3, and MUC1 differed by tumor subtype in some histologic groups ALDH1-positive cells were more frequent in basal-like and HER2+ than in luminal tumors CD44+/CD24− cells were detected in 69% of all tumors with 100% of the basal-like and 52% of HER2+ tumors having some of these cells Conclusions: Our findings suggest that in breast cancer, the frequency of tumor cells positive for stem cell–like and more differentiated cell markers varies according to tumor subtype and histologic stage Clin Cancer Res; 16(3); 876–87

Search for Neutrinoless Double-Beta Decay in $^{136}$Xe with EXO-200

Abstract: Several properties of neutrinos, such as their absolute mass, their possible Majorana nature or the mechanisms that lead to small neutrino masses, are still unknown. The EXO-200 experiment is trying to answer some of these questions by searching for the hypothetical neutrinoless double beta decay of the isotope 136 Xe. This thesis describes an analysis of two years of detector data, which yields a lower limit on the half-life of neutrinoless double beta decay of 136 Xe of 1.1·10 25 years.

Minimum-energy asynchronous dissemination to mobile sinks in wireless sensor networks

Abstract: Data dissemination from sources to sinks is one of the main functions in sensor networks. In this paper, we propose SEAD, a Scalable Energy-efficient Asynchronous Dissemination protocol, to minimize energy consumption in both building the dissemination tree and disseminating data to mobile sinks. SEAD considers the distance and the packet traffic rate among nodes to create near-optimal dissemination trees. The sinks can move without reporting their location to the tree while receiving data updates successfully. Our evaluation results illustrate that SEAD consumes less energy on building and maintaining a dissemination tree to multiple mobile sinks compared to other approaches such as directed diffusion, TTDD, and mobile ad hoc multicast.

Photocatalytic hydrogen generation from hydriodic acid using methylammonium lead iodide in dynamic equilibrium with aqueous solution

Abstract: Organometal halide perovskite materials have been the subject of intensive research efforts in the context of photovoltaic applications. Here the authors exploit dynamic equilibrium to photocatalytically generate hydrogen from aqueous HI solutions using methylammonium lead iodide.

Effects of supply chain management practices, integration and competition capability on performance

Abstract: Purpose – The purpose of this research is to examine the causal linkages among supply chain management (SCM) practice, competition capability, the level of supply chain (SC) integration, and firm performance.Design/methodology/approach – This is helpful in developing a framework for linking a firm's SC integration strategy to its competitive strategy, and in identifying how such a linkage can be connected to the improvement of organizational performance. Such effort also should enable us to derive a set of recommended strategies of SCM practices for SC integration.Findings – From the results of LISREL analysis on small and large manufacturing firms, this paper finds that, in small firms, efficient SC integration may play a more critical role for sustainable performance improvement, while, in large firms, the close interrelationship between the level of SCM practices and competition capability may have more significant effect on performance improvement. It is concluded that, in early stage, the emphasis on...