Seoul National University

About: Seoul National University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 65879 authors who have published 138759 publications receiving 3715170 citations. The organization is also known as: SNU & Seoul-dae.

Making sense of performance in data analytics frameworks

Abstract: There has been much research devoted to improving the performance of data analytics frameworks, but comparatively little effort has been spent systematically identifying the performance bottlenecks of these systems. In this paper, we develop blocked time analysis, a methodology for quantifying performance bottlenecks in distributed computation frameworks, and use it to analyze the Spark framework's performance on two SQL benchmarks and a production workload. Contrary to our expectations, we find that (i) CPU (and not I/O) is often the bottleneck, (ii) improving network performance can improve job completion time by a median of at most 2%, and (iii) the causes of most stragglers can be identified.

The Visual Object Tracking VOT2014 challenge results

Abstract: The Visual Object Tracking challenge 2014, VOT2014, aims at comparing short-term single-object visual trackers that do not apply pre-learned models of object appearance. Results of 38 trackers are presented. The number of tested trackers makes VOT 2014 the largest benchmark on short-term tracking to date. For each participating tracker, a short description is provided in the appendix. Features of the VOT2014 challenge that go beyond its VOT2013 predecessor are introduced: (i) a new VOT2014 dataset with full annotation of targets by rotated bounding boxes and per-frame attribute, (ii) extensions of the VOT2013 evaluation methodology, (iii) a new unit for tracking speed assessment less dependent on the hardware and (iv) the VOT2014 evaluation toolkit that significantly speeds up execution of experiments. The dataset, the evaluation kit as well as the results are publicly available at the challenge website (http://votchallenge.net).

Aminoacyl tRNA synthetases and their connections to disease

Abstract: Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as aminoacyl tRNA synthetases (AARSs). Surprisingly, the etiology of specific diseases—including cancer, neuronal pathologies, autoimmune disorders, and disrupted metabolic conditions—is connected to specific aminoacyl tRNA synthetases. These connections include heritable mutations in the genes for tRNA synthetases that are causally linked to disease, with both dominant and recessive disease-causing mutations being annotated. Because some disease-causing mutations do not affect aminoacylation activity or apparent enzyme stability, the mutations are believed to affect functions that are distinct from aminoacylation. Examples include enzymes that are secreted as procytokines that, after activation, operate in pathways connected to the immune system or angiogenesis. In addition, within cells, synthetases form multiprotein complexes with each other or with other regulatory factors and in that way control diverse signaling pathways. Although much has been uncovered in recent years, many novel functions, disease connections, and interpathway connections of tRNA synthetases have yet to be worked out.

The molecular targets and therapeutic uses of curcumin in health and disease

Abstract: Curcumin: The Indian Solid Gold .- Highly Active Anti-Cancer Curcumin Analogs.- Antioxidant And Anti-Inflammatory Properties Of Curcumin.- Modulation Of Transcription Factors By Curcumin .- Cancer Chemopreventive Effects Of Curcumin.- Anti-Tumor, Anti-Invasion And Antimetastatic Effects Of Curcumin.- Curcumin As An Inhibitor Of Angiogenesis.- Neuroprotective Effects Of Curcumin.- Regulation Of Cox And Lox By Curcumin.- Molecular Targets Of Curcumin.- Cell Growth Regulation.- Curcumin As Chemosensitizer.- Radioprotection And Radiosensitization By Curcumin.- Immunomodulation By Curcumin.- Beneficial Role Of Curcumin In Skin Diseases.- Cardioprotective Effects Of Curcumin.- Protection From Acute And Chronic Lung Diseases By Curcumin.- Nephroprotective And Hepatoprotective Effects Of Curcuminoids.- Curcumin And Autoimmune Disease.- Pharmacokinetics And Pharmacodynamics Of Curcumin.- Clinical Studies With Curcumin.