Institution
Seoul National University
Education•Seoul, South Korea•
About: Seoul National University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 65879 authors who have published 138759 publications receiving 3715170 citations. The organization is also known as: SNU & Seoul-dae.
Topics: Population, Catalysis, Thin film, Gene, Cancer
Papers published on a yearly basis
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University of California, San Francisco1, Technische Universität München2, University of California, Los Angeles3, Seoul National University4, Kaiser Permanente5, Rabin Medical Center6, University of Texas MD Anderson Cancer Center7, Complutense University of Madrid8, Sungkyunkwan University9, Pfizer10
TL;DR: Among patients with advanced breast cancer and a germline BRCA1/2 mutation, single‐agent talazoparib provided a significant benefit over standard chemotherapy with respect to progression‐free survival.
Abstract: Background The poly(adenosine diphosphate–ribose) inhibitor talazoparib has shown antitumor activity in patients with advanced breast cancer and germline mutations in BRCA1 and BRCA2 (BRCA1/2). Methods We conducted a randomized, open-label, phase 3 trial in which patients with advanced breast cancer and a germline BRCA1/2 mutation were assigned, in a 2:1 ratio, to receive talazoparib (1 mg once daily) or standard single-agent therapy of the physician’s choice (capecitabine, eribulin, gemcitabine, or vinorelbine in continuous 21-day cycles). The primary end point was progression-free survival, which was assessed by blinded independent central review. Results Of the 431 patients who underwent randomization, 287 were assigned to receive talazoparib and 144 were assigned to receive standard therapy. Median progression-free survival was significantly longer in the talazoparib group than in the standard-therapy group (8.6 months vs. 5.6 months; hazard ratio for disease progression or death, 0.54; 95% c...
1,298 citations
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Harvard University1, Seoul National University2, Fox Chase Cancer Center3, Agency for Science, Technology and Research4, Autonomous University of Barcelona5, University of Washington6, University of Colorado Denver7, Katholieke Universiteit Leuven8, University of Utah9, Memorial Sloan Kettering Cancer Center10, Peter MacCallum Cancer Centre11, University of Cologne12, Heidelberg University13, University of Duisburg-Essen14, German Cancer Research Center15, Princess Margaret Cancer Centre16, Novartis17
TL;DR: Ceritinib was highly active in patients with advanced, ALK-rearranged NSCLC, including those who had had disease progression during crizotinib treatment, regardless of the presence of resistance mutations in ALK.
Abstract: BackgroundNon–small-cell lung cancer (NSCLC) harboring the anaplastic lymphoma kinase gene (ALK) rearrangement is sensitive to the ALK inhibitor crizotinib, but resistance invariably develops. Ceritinib (LDK378) is a new ALK inhibitor that has shown greater antitumor potency than crizotinib in preclinical studies. MethodsIn this phase 1 study, we administered oral ceritinib in doses of 50 to 750 mg once daily to patients with advanced cancers harboring genetic alterations in ALK. In an expansion phase of the study, patients received the maximum tolerated dose. Patients were assessed to determine the safety, pharmacokinetic properties, and antitumor activity of ceritinib. Tumor biopsies were performed before ceritinib treatment to identify resistance mutations in ALK in a group of patients with NSCLC who had had disease progression during treatment with crizotinib. ResultsA total of 59 patients were enrolled in the dose-escalation phase. The maximum tolerated dose of ceritinib was 750 mg once daily; dose-l...
1,297 citations
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TL;DR: In this article, a narrow charmonium-like state produced in the exclusive decay process B+/--->K+/-pi(+)pi(-)J/psi has been observed, which has a mass of 3872.0+/-0.6(stat)+/- 0.5(syst) MeV.
Abstract: We report the observation of a narrow charmoniumlike state produced in the exclusive decay process B+/--->K+/-pi(+)pi(-)J/psi. This state, which decays into pi(+)pi(-)J/psi, has a mass of 3872.0+/-0.6(stat)+/-0.5(syst) MeV, a value that is very near the M(D0)+M(D(*0)) mass threshold. The results are based on an analysis of 152M B-Bmacr; events collected at the Upsilon(4S) resonance in the Belle detector at the KEKB collider. The signal has a statistical significance that is in excess of 10sigma.
1,294 citations
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TL;DR: This review focuses on the various types of chitosan derivatives and their use in various tissue engineering applications namely, skin, bone, cartilage, liver, nerve and blood vessel.
1,278 citations
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TL;DR: In this paper, a high-work-function, low-sheet-resistance graphene anode was used to improve the luminous efficiency of organic light-emitting diodes (OLEDs).
Abstract: Although graphene films have a strong potential to replace indium tin oxide anodes in organic light-emitting diodes (OLEDs), to date, the luminous efficiency of OLEDs with graphene anodes has been limited by a lack of efficient methods to improve the low work function and reduce the sheet resistance of graphene films to the levels required for electrodes1,2,3,4. Here, we fabricate flexible OLEDs by modifying the graphene anode to have a high work function and low sheet resistance, and thus achieve extremely high luminous efficiencies (37.2 lm W–1 in fluorescent OLEDs, 102.7 lm W–1 in phosphorescent OLEDs), which are significantly higher than those of optimized devices with an indium tin oxide anode (24.1 lm W–1 in fluorescent OLEDs, 85.6 lm W–1 in phosphorescent OLEDs). We also fabricate flexible white OLED lighting devices using the graphene anode. These results demonstrate the great potential of graphene anodes for use in a wide variety of high-performance flexible organic optoelectronics. By replacing conventional indium tin oxide (ITO) anodes with high-work-function, low-sheet-resistance graphene anodes, researchers demonstrate flexible fluorescent organic LEDs with extremely high luminous efficiencies of 37.2 lm W–1 for fluorescent devices and 102.7 lm W–1 for phosphorescent devices. These values are significantly higher than those of optimized organic LEDs based on ITO anodes.
1,273 citations
Authors
Showing all 66324 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Adi F. Gazdar | 157 | 776 | 104116 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Yongsun Kim | 156 | 2588 | 145619 |
David J. Mooney | 156 | 695 | 94172 |
Roberto Romero | 151 | 1516 | 108321 |
Jongmin Lee | 150 | 2257 | 134772 |
Byung-Sik Hong | 146 | 1557 | 105696 |
Inkyu Park | 144 | 1767 | 109433 |
Teruki Kamon | 142 | 2034 | 115633 |
John L. Hopper | 140 | 1229 | 86392 |
Ali Khademhosseini | 140 | 887 | 76430 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Suyong Choi | 135 | 1495 | 97053 |
Intae Yu | 134 | 1372 | 89870 |