Institution
Seoul National University
Education•Seoul, South Korea•
About: Seoul National University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 65879 authors who have published 138759 publications receiving 3715170 citations. The organization is also known as: SNU & Seoul-dae.
Topics: Population, Catalysis, Thin film, Gene, Cancer
Papers published on a yearly basis
Papers
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TL;DR: The cloned gene JMT encoding an S-adenosyl-l-methionine:jasmonic acid carboxyl methyltransferase (JMT) from Arabidopsis thaliana is cloned and it is suggested that the jasmonic Acid Carboxylmethyltransferase is a key enzyme for jasMonate-regulated plant responses.
Abstract: Methyl jasmonate is a plant volatile that acts as an important cellular regulator mediating diverse developmental processes and defense responses. We have cloned the novel gene JMT encoding an S-adenosyl-l-methionine:jasmonic acid carboxyl methyltransferase (JMT) from Arabidopsis thaliana. Recombinant JMT protein expressed in Escherichia coli catalyzed the formation of methyl jasmonate from jasmonic acid with K(m) value of 38.5 microM. JMT RNA was not detected in young seedlings but was detected in rosettes, cauline leaves, and developing flowers. In addition, expression of the gene was induced both locally and systemically by wounding or methyl jasmonate treatment. This result suggests that JMT can perceive and respond to local and systemic signals generated by external stimuli, and that the signals may include methyl jasmonate itself. Transgenic Arabidopsis overexpressing JMT had a 3-fold elevated level of endogenous methyl jasmonate without altering jasmonic acid content. The transgenic plants exhibited constitutive expression of jasmonate-responsive genes, including VSP and PDF1.2. Furthermore, the transgenic plants showed enhanced level of resistance against the virulent fungus Botrytis cinerea. Thus, our data suggest that the jasmonic acid carboxyl methyltransferase is a key enzyme for jasmonate-regulated plant responses. Activation of JMT expression leads to production of methyl jasmonate that could act as an intracellular regulator, a diffusible intercellular signal transducer, and an airborne signal mediating intra- and interplant communications.
684 citations
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TL;DR: A review on the tectonics and sedimentation of major sedimentary basins and orogenic belts (Late Proterozoic-Neogene) in the Korean peninsula is presented in this paper.
684 citations
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University of Tokyo1, Boston University2, Brookhaven National Laboratory3, University of California, Irvine4, California State University, Dominguez Hills5, George Mason University6, Gifu University7, University of Hawaii8, KEK9, Kobe University10, Kyoto University11, Los Alamos National Laboratory12, Louisiana State University13, University of Maryland, College Park14, Massachusetts Institute of Technology15, University of Minnesota16, State University of New York System17, Nagoya University18, Niigata University19, Osaka University20, Seoul National University21, Shizuoka University22, Tohoku University23, Tokai University24, Tokyo Institute of Technology25, University of Warsaw26, University of Washington27
TL;DR: In this paper, a number of different fits to solar neutrino mixing and mass square difference were performed using 1496 days of Super-Kamiokande-I's solar NE data.
680 citations
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TL;DR: The structures of the TLR2-lipoteichoic acid and the TLr2-PE-DTPA complexes demonstrate that a precise interaction pattern of the head group is essential for a robust immune response byTLR2 heterodimers.
680 citations
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University of Washington1, Harvard University2, University of South Florida3, Fox Chase Cancer Center4, Sheba Medical Center5, Yale University6, Seoul National University7, Johns Hopkins University8, University of North Carolina at Chapel Hill9, Tel Aviv Sourasky Medical Center10, National Taiwan University11, Yonsei University12, Merck & Co.13, University of Chicago14
TL;DR: Fixed-dose pembrolizumab 200 mg administered once every 3 weeks was well tolerated and yielded a clinically meaningful ORR with evidence of durable responses, which supports further development of this regimen in patients with advanced HNSCC.
Abstract: Purpose Treatment with pembrolizumab, an anti-programmed death-1 antibody, at 10 mg/kg administered once every 2 weeks, displayed durable antitumor activity in programmed death-ligand 1 (PD-L1) -positive recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) in the KEYNOTE-012 trial. Results from the expansion cohort, in which patients with HNSCC, irrespective of biomarker status, received a fixed dose of pembrolizumab at a less frequent dosing schedule, are reported. Patients and Methods Patients with R/M HNSCC, irrespective of PD-L1 or human papillomavirus status, received pembrolizumab 200 mg intravenously once every 3 weeks. Imaging was performed every 8 weeks. Primary end points were overall response rate (ORR) per central imaging vendor (Response Evaluation Criteria in Solid Tumors v1.1) and safety. Secondary end points included progression-free survival, overall survival, and association of response and PD-L1 expression. Patients who received one or more doses of pembrolizumab were included in analyses. Results Of 132 patients enrolled, median age was 60 years (range, 25 to 84 years), 83% were male, and 57% received two or more lines of therapy for R/M disease. ORR was 18% (95% CI, 12 to 26) by central imaging vendor and 20% (95% CI, 13 to 28) by investigator review. Median duration of response was not reached (range, ≥ 2 to ≥ 11 months). Six-month progression-free survival and overall survival rates were 23% and 59%, respectively. By using tumor and immune cells, a statistically significant increase in ORR was observed for PD-L1-positive versus -negative patients (22% v 4%; P = .021). Treatment-related adverse events of any grade and grade ≥ 3 events occurred in 62% and 9% of patients, respectively. Conclusion Fixed-dose pembrolizumab 200 mg administered once every 3 weeks was well tolerated and yielded a clinically meaningful ORR with evidence of durable responses, which supports further development of this regimen in patients with advanced HNSCC.
678 citations
Authors
Showing all 66324 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
Adi F. Gazdar | 157 | 776 | 104116 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Yongsun Kim | 156 | 2588 | 145619 |
David J. Mooney | 156 | 695 | 94172 |
Roberto Romero | 151 | 1516 | 108321 |
Jongmin Lee | 150 | 2257 | 134772 |
Byung-Sik Hong | 146 | 1557 | 105696 |
Inkyu Park | 144 | 1767 | 109433 |
Teruki Kamon | 142 | 2034 | 115633 |
John L. Hopper | 140 | 1229 | 86392 |
Ali Khademhosseini | 140 | 887 | 76430 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Suyong Choi | 135 | 1495 | 97053 |
Intae Yu | 134 | 1372 | 89870 |