Institution
Swedish Defence Research Agency
Government•Stockholm, Sweden•
About: Swedish Defence Research Agency is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Radar & Laser. The organization has 1413 authors who have published 2731 publications receiving 56083 citations. The organization is also known as: Totalförsvarets forskningsinstitut.
Papers published on a yearly basis
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TL;DR: A set of novel virulence-associated genes (vag genes) are identified by comparing the genome sequences of six human pathogens that are known to cause persistent or chronic infections in humans by proposing that some vag mutants could serve as carrier strains for live vaccines.
Abstract: The sequencing of bacterial genomes has opened new perspectives for identification of targets for treatment of infectious diseases. We have identified a set of novel virulence-associated genes (vag genes) by comparing the genome sequences of six human pathogens that are known to cause persistent or chronic infections in humans: Yersinia pestis, Neisseria gonorrhoeae, Helicobacter pylori, Borrelia burgdorferi, Streptococcus pneumoniae, and Treponema pallidum. This comparison was limited to genes annotated as hypothetical in the T. pallidum genome project. Seventeen genes with unknown functions were found to be conserved among these pathogens. Insertional inactivation of 14 of these genes generated nine mutants that were attenuated for virulence in a mouse infection model. Out of these nine genes, five were found to be specifically associated with virulence in mice as demonstrated by infection with Yersinia pseudotuberculosis in-frame deletion mutants. In addition, these five vag genes were essential only in vivo, since all the mutants were able to grow in vitro. These genes are broadly conserved among bacteria. Therefore, we propose that the corresponding vag gene products may constitute novel targets for antimicrobial therapy and that some vag mutants could serve as carrier strains for live vaccines.
52 citations
TL;DR: An overview of the key high-power microwave (HPM) narrow-band source technologies and their related HPM open-area radio-frequency (RF) test capabilities within four European counties (France, Germany, Sweden, and the U.K.).
Abstract: This paper presents an overview of the key high-power microwave (HPM) narrow-band source technologies and their related HPM open-area radio-frequency (RF) test capabilities within four European counties (France, Germany, Sweden, and the U.K.). The test facilities are described and a brief description of further developments is given covering both power limitations and recent research interests.
52 citations
TL;DR: Treatment with dexamethasone significantly counteracted the acute inflammatory response but was insufficient for complete protection against SO2-induced adverse effects, i.e. treatment only provided partial protection against AHR and the long-term fibrosis.
52 citations
TL;DR: In this paper, composite bolted joints made from carbon fiber/epoxy material with quasi-isotropic and 0°-dominated lay-ups were fatigue tested to investigate their fatigue resistance.
52 citations
TL;DR: The overall results indicate the involvement of cellular free-radical formation in the pulmonary cytokine responses to particles of varying composition in mice that lacked either NADPH-oxidase or iNOS.
Abstract: Involvement of NADPH oxidase and iNOS in rodent pulmonary cytokine responses to urban air and mineral particles.
52 citations
Authors
Showing all 1417 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Anders Larsson | 80 | 1307 | 33995 |
| Anders Johansson | 75 | 538 | 21709 |
| Anders Eriksson | 68 | 679 | 19487 |
| Dan S. Henningson | 66 | 369 | 19038 |
| Bengt Johansson | 66 | 635 | 19206 |
| Anders Sjöstedt | 63 | 196 | 11422 |
| Björn Johansson | 62 | 637 | 16030 |
| Mats Gustafsson | 61 | 520 | 18574 |
| D. G. Joakim Larsson | 58 | 151 | 13687 |
| Anders Larsson | 54 | 198 | 55761 |
| Mats Tysklind | 53 | 250 | 17534 |
| Jerker Fick | 51 | 143 | 8787 |
| Erik Johansson | 50 | 114 | 9437 |
| Göran Finnveden | 49 | 193 | 12663 |
| Ian A. Nicholls | 45 | 194 | 7522 |