Swedish Defence Research Agency

About: Swedish Defence Research Agency is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Radar & Laser. The organization has 1413 authors who have published 2731 publications receiving 56083 citations. The organization is also known as: Totalförsvarets forskningsinstitut.

Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial

Abstract: Background/Objectives Inflammation and oxidative stress are central in many disease states. The major anti-oxidative enzymes contain selenium. The selenium intake in Europe is low, and supplementat ...

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test

Abstract: The detection and identification of botulinum neurotoxins (BoNT) is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical approaches to detect, identify and quantify BoNT, but due to the lack of (certified) reference materials, analytical results can hardly be compared. In this study, the six BoNT/A1-F1 prototypes were successfully produced by recombinant techniques, facilitating handling, as well as improving purity, yield, reproducibility and biosafety. All six BoNTs were quantitatively nicked into active di-chain toxins linked by a disulfide bridge. The materials were thoroughly characterized with respect to purity, identity, protein concentration, catalytic and biological activities. For BoNT/A₁, B₁ and E₁, serotypes pathogenic to humans, the catalytic activity and the precise protein concentration were determined by Endopep-mass spectrometry and validated amino acid analysis, respectively. In addition, BoNT/A₁, B₁, E₁ and F₁ were successfully detected by immunological assays, unambiguously identified by mass spectrometric-based methods, and their specific activities were assigned by the mouse LD50 bioassay. The potencies of all six BoNT/A1-F1 were quantified by the ex vivo mouse phrenic nerve hemidiaphragm assay, allowing a direct comparison. In conclusion, highly pure recombinant BoNT reference materials were produced, thoroughly characterized and employed as spiking material in a worldwide BoNT proficiency test organized by the EQuATox consortium.

Range accuracy and resolution for laser radars

Abstract: Laser radars offer a potential for high range accuracy and range resolution due to short pulses and high bandwidth receivers. For angular non-resolved targets (1 D profiling) the analysis of the waveform offers the possibility of target recognition due to range profiling. For 2 D and 3 D imaging the angular and range resolution are the critical parameters for target recognition while in other applications such as in lidar mapping the range accuracy plays an important role for the performance. The development of the next generation laser radars including 3 D sensing focal plane arrays (FPAs) enable a full range and intensity image to be captured in one laser shot. Moreover, gated viewing systems also give a viable solution for providing 3 D target information. This paper uses simulation to illustrate the limits for accuracy and range resolution in waveform processing due to the laser pulse shape, detector noise, target shape and reflectivity as well as turbulence.

Explosives standoff detection using Raman spectroscopy: from bulk towards trace detection

Abstract: This paper gives a brief overview on our latest progress in the area of standoff detection. Standoff Raman measurements from 200 m and 470 m distance have been performed on bulk amounts of TATP and AN respectively, the former through a double sided window, the latter under heavy rain. Resonance Raman measurements on TNT, DNT and NM vapors in the ppm concentration regime are presented, showing resonance enhancement in the range of 2 200 (NM) to 57 000 (TNT) as compared to 532 nm Raman cross sections. Finally, the application of hyper spectral Raman imaging is described, exemplified by the resolution of four different samples (sulphur, AN, DNT, and TNT) in the form of 5 mm wide discs in one single image.

Ground Target Recognition Using Rectangle Estimation

Abstract: We propose a ground target recognition method based on 3-D laser radar data. The method handles general 3-D scattered data. It is based on the fact that man-made objects of complex shape can be decomposed to a set of rectangles. The ground target recognition method consists of four steps; 3-D size and orientation estimation, target segmentation into parts of approximately rectangular shape, identification of segments that represent the target's functional/main parts, and target matching with CAD models. The core in this approach is rectangle estimation. The performance of the rectangle estimation method is evaluated statistically using Monte Carlo simulations. A case study on tank recognition is shown, where 3-D data from four fundamentally different types of laser radar systems are used. Although the approach is tested on rather few examples, we believe that the approach is promising