Swedish Institute

About: Swedish Institute is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 1657 authors who have published 2301 publications receiving 103682 citations. The organization is also known as: Svenska Institutet.

Addition of a macrolide to a ss-lactam in bacteremic pneumococcal pneumonia.

Abstract: In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a s-lactam +/− a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/s-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age >65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)>8.

General practitioners' and district nurses' conceptions of the encounter with obese patients in primary health care.

Abstract: Background: Primary health care specialists have a key role in the management of obesity. Through understanding how they conceive the encounter with patients with obesity, treatment may be improved. The aim of this study was thus to explore general practitioners’ and district nurses’ conceptions of encountering patients with obesity in primary health care. Method: Data were collected through semi-structured interviews, and analysed using a phenomenographic approach. The participants were 10 general practitioners (6 women, 4 men) and 10 district nurses (7 women, 3 men) from 19 primary health care centres within a well-defined area of Sweden. Results: Five descriptive categories were identified: Adequate primary health care, Promoting lifestyle change, Need for competency, Adherence to new habits and Understanding patient attitudes. All participants, independent of gender and profession, were represented in the descriptive categories. Some profession and gender differences were, however, found in the underlying conceptions. The general staff view was that obesity had to be prioritised. However, there was also the contradictory view that obesity is not a disease and therefore not the responsibility of primary health care. Despite this, staff conceived it as important that patients were met with respect and that individual solutions were provided which could be adhered to step-by-step by the patient. Patient attitudes, such as motivation to change, evasive behaviour, too much trust in care and lack of self-confidence, were, however, conceived as major barriers to a fruitful encounter. Conclusions: Findings from this study indicate that there is a need for development and organisation of weight management in primary health care. Raising awareness of staff’s negative views of patient attitudes is important since it is likely that it affects the patient-staff relationship and staff’s treatment efforts. More research is also needed on gender and profession differences in this area. Background

Living with a chronic deteriorating disease: the trajectory with muscular dystrophy over ten years.

Abstract: Purpose: The aim of the study was to elucidate experiences of living with muscular dystrophy in terms of consequences for activity over 10 years. Methods: The study population was identified in a p ...

Mutation profile of the CDH23 gene in 56 probands with Usher syndrome type I.

Abstract: Mutations in the human gene encoding cadherin 23 (CDH23) cause Usher syndrome type 1D (USH1D) and nonsyndromic hearing loss Individuals with Usher syndrome type I have profound congenital deafness, vestibular areflexia and usually begin to exhibit signs of RP in early adolescence In the present study, we carried out the mutation analysis in all 69 exons of the CDH23 gene in 56 Usher type 1 probands already screened for mutations in MYO7A A total of 18 of 56 subjects (321%) were observed to have one or two CDH23 variants that are presumed to be pathologic Twenty one different pathologic genome variants were observed of which 15 were novel Out of a total of 112 alleles, 31 (277%) were considered pathologic Based on our results it is estimated that about 20% of patients with Usher syndrome type I have CDH23 mutations