Institution
Swedish Institute
Government•Stockholm, Sweden•
About: Swedish Institute is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 1657 authors who have published 2301 publications receiving 103682 citations. The organization is also known as: Svenska Institutet.
Topics: Population, Health care, Cost effectiveness, Virus, Vaccination
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors used a flat-headed punch of diameter 100 mm and a hemispherical punched of diameter 25 mm to measure the stiffness and dent resistance of a panel.
50 citations
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TL;DR: The results showed that A. phagocytophilum circulating in Eastern Europe belongs to different groESL lineages and 16S rRNA gene variants and also consists of variable numbers of repetitive elements within the ankA gene.
50 citations
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TL;DR: In this paper, the authors compared two flow cytometric methods (MultiSET and SimulSET) for the quantification of lymphocyte subsets using whole blood from 92 HIV seropositive and 241 seronegative adults, and determined the reference values of lymphocytes subsets in HIV serone gative Tanzanian subjects.
50 citations
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TL;DR: In this article, the subgrain growth during annealing of cold-worked Al-1% Mn and Al(4N) has been measured in the temperature intervals 300 to 400° C and 100 to 200° C respectively.
Abstract: The subgrain growth during annealing of cold-worked Al-1% Mn and Al(4N) has been measured in the temperature intervals 300 to 400° C and 100 to 200° C respectively. For Al-1%Mn the subgrain diameter showed a parabolic growth, while for Al the diameter gradually reached a constant value. The microstructural investigations which included in situ annealing in a high voltage electron microscope demonstrated that the operating mechanism for growth in the higher temperature range was collective migration of sub-boundary dislocations. In the lower temperature range extraction of dislocations was found to be the dominating mechanism, i.e. dislocations partly lying in the boundaries are pulled out by the stress field in the subgrain interior. The observed growth rates were consistent with models for these mechanisms presented in two previous papers.
50 citations
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TL;DR: Overall, the studies do not reveal any potential negative effects imparted by the in vivo interaction between WT Env and primate CD4 on the generation of functional T cells and antibodies in response to soluble Env vaccination.
Abstract: The high-affinity in vivo interaction between soluble HIV-1 envelope glycoprotein (Env) immunogens and primate CD4 results in conformational changes that alter the immunogenicity of the gp120 subunit. Because the conserved binding site on gp120 that directly interacts with CD4 is a major vaccine target, we sought to better understand the impact of in vivo Env-CD4 interactions during vaccination. Rhesus macaques were immunized with soluble wild-type (WT) Env trimers, and two trimer immunogens rendered CD4 binding defective through distinct mechanisms. In one variant, we introduced a mutation that directly disrupts CD4 binding (368D/R). In the second variant, we introduced three mutations (423I/M, 425N/K, and 431G/E) that disrupt CD4 binding indirectly by altering a gp120 subdomain known as the bridging sheet, which is required for locking Env into a stable interaction with CD4. Following immunization, Env-specific binding antibody titers and frequencies of Env-specific memory B cells were comparable between the groups. However, the quality of neutralizing antibody responses induced by the variants was distinctly different. Antibodies against the coreceptor binding site were elicited by WT trimers but not the CD4 binding-defective trimers, while antibodies against the CD4 binding site were elicited by the WT and the 423I/M, 425N/K, and 431G/E trimers but not the 368D/R trimers. Furthermore, the CD4 binding-defective trimer variants stimulated less potent neutralizing antibody activity against neutralization-sensitive viruses than WT trimers. Overall, our studies do not reveal any potential negative effects imparted by the in vivo interaction between WT Env and primate CD4 on the generation of functional T cells and antibodies in response to soluble Env vaccination.
50 citations
Authors
Showing all 1667 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kevin Marsh | 128 | 567 | 55356 |
Gerhard Andersson | 118 | 902 | 49159 |
Staffan Normark | 96 | 289 | 29787 |
Tirone E. David | 82 | 382 | 22078 |
Olof Nyrén | 78 | 274 | 23034 |
Antonella d'Arminio Monforte | 74 | 462 | 26093 |
Björn Lindman | 74 | 526 | 21454 |
Job J. Bwayo | 74 | 190 | 16928 |
Jan Albert | 73 | 323 | 19740 |
Dan I. Andersson | 73 | 257 | 20958 |
Jan Vinjé | 72 | 233 | 19778 |
Helena Johansson | 72 | 320 | 27007 |
David Bergqvist | 71 | 597 | 22200 |
Lars Engstrand | 69 | 302 | 20090 |
Joan Ivanov | 67 | 211 | 13473 |