Institution
Universidad del Norte, Colombia
Education•Barranquilla, Colombia•
About: Universidad del Norte, Colombia is a education organization based out in Barranquilla, Colombia. It is known for research contribution in the topics: Population & Context (language use). The organization has 3562 authors who have published 4355 publications receiving 37861 citations. The organization is also known as: University of the North, Colombia & Uninorte.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the photocatalytic activity of the sensitized material S. cumini was ∼3 times greater than unmodified TiO2 thin films, which let us to propose that the extract from Caribbean Colombian S. Cumini could have a great potential as source of photosensitizers for photocatalysis applications.
25 citations
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TL;DR: Tau hyperphosphorylation pattern, and its degradation by the proteasome, drastically influences disease onset in individuals with otherwise similar Aβ pathology, hinting toward a multifactorial model of disease for FAD.
Abstract: Presenilin-1 (PSEN1) mutations cause familial Alzheimer’s disease (FAD) characterized by early age of onset (AoO). Examination of a large kindred harboring the PSEN1-E280A mutation reveals a range of AoO spanning 30 years. The pathophysiological drivers and clinical impact of AoO variation in this population are unknown. We examined brains of 23 patients focusing on generation and deposition of beta-amyloid (Aβ) and Tau pathology profile. In 14 patients distributed at the extremes of AoO, we performed whole-exome capture to identify genotype–phenotype correlations. We also studied kinome activity, proteasome activity, and protein polyubiquitination in brain tissue, associating it with Tau phosphorylation profiles. PSEN1-E280A patients showed a bimodal distribution for AoO. Besides AoO, there were no clinical differences between analyzed groups. Despite the effect of mutant PSEN1 on production of Aβ, there were no relevant differences between groups in generation and deposition of Aβ. However, differences were found in hyperphosphorylated Tau (pTau) pathology, where early onset patients showed severe pathology with diffuse aggregation pattern associated with increased activation of stress kinases. In contrast, late-onset patients showed lesser pTau pathology and a distinctive kinase activity. Furthermore, we identified new protective genetic variants affecting ubiquitin–proteasome function in early onset patients, resulting in higher ubiquitin-dependent degradation of differentially phosphorylated Tau. In PSEN1-E280A carriers, altered γ-secretase activity and resulting Aβ accumulation are prerequisites for early AoO. However, Tau hyperphosphorylation pattern, and its degradation by the proteasome, drastically influences disease onset in individuals with otherwise similar Aβ pathology, hinting toward a multifactorial model of disease for FAD. In sporadic AD (SAD), a wide range of heterogeneity, also influenced by Tau pathology, has been identified. Thus, Tau-induced heterogeneity is a common feature in both AD variants, suggesting that a multi-target therapeutic approach should be used to treat AD.
25 citations
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TL;DR: Results show that applications designed for voluntary use to prevent mobile phone distracted driving are a promising countermeasure, although current applications require several improvements.
25 citations
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TL;DR: A simple score based on demographic and clinical factors allows stratification of bacteremic patients according to their risk of MDR-PA BSI, and may help facilitate the use of rapid M DR-detection tools and improve early antibiotic appropriateness.
25 citations
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TL;DR: The data indicate that circulating cytokines and chemokines could be considered good predictors of renal involvement in individuals with systemic lupus erythematosus.
Abstract: BackgroundSystemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and or...
25 citations
Authors
Showing all 3594 results
Name | H-index | Papers | Citations |
---|---|---|---|
Sid E. O'Bryant | 41 | 168 | 8123 |
Francisco Rothhammer | 39 | 191 | 8247 |
Juan Carlos Niebles | 37 | 70 | 9751 |
Miguel A. Labrador | 36 | 193 | 5951 |
Alcides Chaux | 35 | 121 | 4795 |
Calogero M. Santoro | 30 | 157 | 3041 |
Toby Miller | 30 | 378 | 4694 |
Diego Viasus | 29 | 75 | 2069 |
Carlos Lizama | 28 | 183 | 2617 |
Robert Pitt | 28 | 234 | 4015 |
Camilo Montes | 28 | 74 | 2878 |
James Hall | 27 | 114 | 2785 |
Luis A. Cisternas | 26 | 154 | 2012 |
Antonio Rodríguez Andrés | 26 | 91 | 2151 |
Ana C. Fonseca | 26 | 120 | 2608 |