Universidad del Norte, Colombia

About: Universidad del Norte, Colombia is a education organization based out in Barranquilla, Colombia. It is known for research contribution in the topics: Population & Context (language use). The organization has 3562 authors who have published 4355 publications receiving 37861 citations. The organization is also known as: University of the North, Colombia & Uninorte.

Factors Influencing the Distribution and Characteristics of Surface Sediment in the Bay of Cartagena, Colombia

Abstract: Restrepo, J.C.; Escobar, J.; Otero, L.; Franco, D.; Pierini, J., and Correa, I., 2017. Factors influencing the distribution and characteristics of surface sediment in the Bay of Cartagena, Colombia. This study evaluated patterns of coastal sediment movement and deposition under different seasonal conditions (warm and cold phases of the El Nino–Southern Oscillation [ENSO] and normal conditions) in Cartagena Bay, Colombia. A calibrated numerical model (MOHID modeling system) was applied to assess the spatial distribution of sediments transported by the Canal del Dique to the bay and studied the spatial distribution and major textural characteristics of 234 surface sediment samples. Currents in the Bay of Cartagena are controlled primarily by the strength and direction of the wind. Model results show major sediment deposition in the southern sector of the bay during the dry season. More homogenous spatial distribution of sediments throughout the Bay of Cartagena occurs with an increase in river inpu...

In vivo and in vitro antimalarial activity of 4-nerolidylcatechol.

Abstract: 4-Nerolidylcatechol (4-NC) isolated from Piper peltatum L. (Piperaceae) was evaluated for in vitro antiplasmodial activity against Plasmodium falciparum (cultures of both standard CQR (K1) and CQS (3D7) strains and two Amazonian field isolates) and for in vivo antimalarial activity using the Plasmodium berghei-murine model. 4-NC exhibits significant in vitro and moderate in vivo antiplasmodial activity. 4-NC administered orally and subcutaneously at doses of 200, 400 and 600 mg/kg/day suppressed the growth of P. berghei by up to 63% after four daily treatments (days 1-4). Also, 4-NC exhibited important in vitro antiplasmodial activity against both standard and field P. falciparum strains in which 50% inhibition of parasite growth (IC(50) ) was produced at concentrations of 0.05-2.11 μg/mL and depended upon the parasite strain. Interestingly, healthy (non-infected) mice that received 4-NC orally presented (denatured) blood plasma which exhibited significant in vitro activity against P. falciparum. This is evidence that mouse metabolism allows 4-NC or active metabolites to enter the blood. Further chemical and pharmacological studies are necessary to confirm the potential of 4-NC as a new antimalarial prototype.

El maltrato entre iguales por abuso de poder y exclusión social en estudiantes de una universidad privada de la ciudad de Barranquilla

Abstract: In this paper we present the results of a descriptive study whose main goal was to determine the incidence of peer maltreatment due to the abuse of power and social exclusion, demonstrated in a sample of 116 students of a private university in the city of Barranquilla. We used a student questionnaire (Defensor Del Pueblo, 2000) originally designed for school populations in Spain, and subsequently adapted to Colombia by Hoyos and Cordoba (2005). For the purposes of this research we made adjustments to this questionnaire in relation to a university context. The results confirm the presence of peer maltreatment in the university, although the situation is not alarming. The phenomenon is presented with some particularities among all ages and semesters, as well as both genders. It is worth mentioning that verbal abuse is the most common manifestation, especially speaking badly about others, using nicknames, followed by social exclusion.

Antimicrobial Activity of Quinoline-Based Hydroxyimidazolium Hybrids

Abstract: Eight quinoline-based hydroxyimidazolium hybrids 7a–h were prepared and evaluated in vitro against a panel of clinically important fungal and bacterial pathogens, including mycobacteria. Hybrid compounds 7c–d showed remarkable antifungal activity against Cryptococcus neoformans with a minimum inhibitory concentration (MIC) value of 15.6 µg/mL. Against other opportunistic fungi such as Candida spp. and Aspergillus spp., these hybrids showed MIC values of 62.5 µg/mL. Regarding their antibacterial activity, all the synthetic hybrids demonstrated little inhibition of Gram-negative bacteria (MIC ≥50 µg/mL), however, hybrid 7b displayed >50% inhibition against Klebsiella pneumoniae at 20 µg/mL and full inhibition at 50 µg/mL. Moreover, this hybrid was shown to be a potent anti-staphylococcal molecule, with a MIC value of 2 µg/mL (5 µM). In addition, hybrid 7h also demonstrated inhibition of Staphylococcus aureus at 20 µg/mL (47 µM). Hybrids 7a and 7b were the most potent against Mycobacterium tuberculosis H37Rv with MIC values of 20 and 10 µg/mL (46 and 24 µM), respectively. The 7b hybrid demonstrated high selectivity in killing S. aureus and M. tuberculosis H37Rv in comparison with mammalian cells (SI >20), and thus it can be considered a hit molecule for mechanism of action studies and the exploration of related chemical space.