Institution
University of Freiburg
Education•Freiburg, Baden-Württemberg, Germany•
About: University of Freiburg is a education organization based out in Freiburg, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 41992 authors who have published 77296 publications receiving 2896269 citations. The organization is also known as: alberto-ludoviciana & Albert-Ludwigs-Universität Freiburg.
Topics: Population, Transplantation, Gene, Large Hadron Collider, Medicine
Papers published on a yearly basis
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940 citations
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TL;DR: This work characterize a nuclear protein interaction cascade mediating transduction of GA signals to the activity regulation of a light-responsive transcription factor in the presence of GA, and releases PIF3 from the negative effect of DELLA proteins.
Abstract: Light and gibberellins (GAs) mediate many essential and partially overlapping plant developmental processes. DELLA proteins are GA-signalling repressors that block GA-induced development. GA induces degradation of DELLA proteins via the ubiquitin/proteasome pathway, but light promotes accumulation of DELLA proteins by reducing GA levels. It was proposed that DELLA proteins restrain plant growth largely through their effect on gene expression. However, the precise mechanism of their function in coordinating GA signalling and gene expression remains unknown. Here we characterize a nuclear protein interaction cascade mediating transduction of GA signals to the activity regulation of a light-responsive transcription factor. In the absence of GA, nuclear-localized DELLA proteins accumulate to higher levels, interact with phytochrome-interacting factor 3 (PIF3, a bHLH-type transcription factor) and prevent PIF3 from binding to its target gene promoters and regulating gene expression, and therefore abrogate PIF3-mediated light control of hypocotyl elongation. In the presence of GA, GID1 proteins (GA receptors) elevate their direct interaction with DELLA proteins in the nucleus, trigger DELLA protein's ubiquitination and proteasome-mediated degradation, and thus release PIF3 from the negative effect of DELLA proteins.
938 citations
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TL;DR: It is shown that dimers of the UVR8 protein perceive UV-B, probably by a tryptophan-based mechanism, which mediatesUV-B photomorphogenic responses securing plant acclimation and thus promotes survival in sunlight.
Abstract: To optimize their growth and survival, plants perceive and respond to ultraviolet-B (UV-B) radiation. However, neither the molecular identity of the UV-B photoreceptor nor the photoperception mechanism is known. Here we show that dimers of the UVR8 protein perceive UV-B, probably by a tryptophan-based mechanism. Absorption of UV-B induces instant monomerization of the photoreceptor and interaction with COP1, the central regulator of light signaling. Thereby this signaling cascade controlled by UVR8 mediates UV-B photomorphogenic responses securing plant acclimation and thus promotes survival in sunlight.
938 citations
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University of Western Australia1, University of Yamanashi2, University of Newcastle3, National Oceanic and Atmospheric Administration4, University of South Carolina5, University of California, Berkeley6, Oregon State University7, University of São Paulo8, Newcastle University9, University of Saskatchewan10, University of Freiburg11
TL;DR: The IAHS Decade on Predictions in Ungauged Basins (PUB) as discussed by the authors is a new initiative launched by the International Association of Hydrological Sciences (IAHS) aimed at formulating and implementing appropriate science programmes to engage and energize the scientific community, in a coordinated manner, towards achieving major advances in the capacity to make predictions in ungauged basins.
Abstract: Drainage basins in many parts of the world are ungauged or poorly gauged, and in some cases existing measurement networks are declining. The problem is compounded by the impacts of human-induced changes to the land surface and climate, occur-ring at the local, regional and global scales. Predictions of ungauged or poorly gauged basins under these conditions are highly uncertain. The IAHS Decade on Predictions in Ungauged Basins, or PUB, is a new initiative launched by the International Association of Hydrological Sciences (IAHS), aimed at formulating and implementing appropriate science programmes to engage and energize the scientific community, in a coordinated manner, towards achieving major advances in the capacity to make predictions in ungauged basins. The PUB scientific programme focuses on the estimation of predictive uncertainty, and its subsequent reduction, as its central theme. A general hydrological prediction system contains three components: (a) a model that describes the key processes of interest, (b) a set of parameters that represent those landscape properties that govern critical processes, and (c) appropriate meteorological inputs (where needed) that drive the basin response. Each of these three components of the prediction system, is either not known at all, or at best known imperfectly, due to the inherent multi-scale space-time heterogeneity of the hydrological system, especially in ungauged basins. PUB will therefore include a set of targeted scientific programmes that attempt to make inferences about climatic inputs, parameters and model structures from available but inadequate data and process knowledge, at the basin of interest and/or from other similar basins, with robust measures of the uncertainties involved, and their impacts on predictive uncertainty. Through generation of improved understanding, and methods for the efficient quantification of the underlying multi-scale heterogeneity of the basin and its response, PUB will inexorably lead to new, innovative methods for hydrological predictions in ungauged basins in different parts of the world, combined with significant reductions of predictive uncertainty. In this way, PUB will demonstrate the value of data, as well as provide the information needed to make predictions in ungauged basins, and assist in capacity building in the use of new technologies. This paper presents a summary of the science and implementation plan of PUB, with a call to the hydrological community to participate actively in the realization of these goals.
938 citations
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TL;DR: The physiological equivalent temperature (PET) as discussed by the authors is a thermal index derived from the human energy balance, which is well suited to the evaluation of the thermal component of different climates and can be presented graphically or as bioclimatic maps.
Abstract: The physiological equivalent temperature, PET, is a thermal index derived from the human energy balance. It is well suited to the evaluation of the thermal component of different climates. As well as having a de- tailed physiological basis, PET is preferable to other thermal indexes like the predicted mean vote because of its unit (°C), which makes results more comprehensible to urban or regional planners, for example, who are not so familiar with modern human-biometeorological termi- nology. PET results can be presented graphically or as bioclimatic maps. Graphs mostly display the temporal behaviour of PET, whereas spatial distribution is speci- fied in bioclimatic maps. In this article, some applica- tions of PET are discussed. They relate to the evaluation of the urban heat island in cities in both temperate cli- mates and warm climates at high altitude. The thermal component of the microclimate in the trunk space of a deciduous forest is also evaluated by PET. As an exam- ple of the spatial distribution of PET, a bioclimatic map for Greece in July (Mediterranean climate) is presented.
925 citations
Authors
Showing all 42309 results
Name | H-index | Papers | Citations |
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Mark Hallett | 186 | 1170 | 123741 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Anders Björklund | 165 | 769 | 84268 |
Si Xie | 148 | 1575 | 120243 |
Kypros H. Nicolaides | 147 | 1302 | 87091 |
Peter J. Schwartz | 147 | 647 | 107695 |
Michael E. Phelps | 144 | 637 | 77797 |
Martin Erdmann | 144 | 1562 | 100470 |
Holger J. Schünemann | 141 | 810 | 113169 |
Maksym Titov | 139 | 1573 | 128335 |
Karl Jakobs | 138 | 1379 | 97670 |
Annette Peters | 138 | 1114 | 101640 |
Suman Bala Beri | 137 | 1608 | 104798 |
Bert Sakmann | 137 | 283 | 90979 |
Vipin Bhatnagar | 137 | 1756 | 104163 |