Institution
University of Freiburg
Education•Freiburg, Baden-Württemberg, Germany•
About: University of Freiburg is a education organization based out in Freiburg, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 41992 authors who have published 77296 publications receiving 2896269 citations. The organization is also known as: alberto-ludoviciana & Albert-Ludwigs-Universität Freiburg.
Topics: Population, Transplantation, Gene, Large Hadron Collider, Medicine
Papers published on a yearly basis
Papers
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Abstract: This paper describes Minerva, an interactive tour-guide robot that was successfully deployed in a Smithsonian museum. Minerva’s software is pervasively probabilistic, relying on explicit representations of uncertainty in perception and control. This article describes Minerva’s major software components, and provides a comparative analysis of the results obtained in the Smithsonian museum. During two weeks of highly successful operation, the robot interacted with thousands of people, both in the museum and through the Web, traversing more than 44km at speeds of up to 163 cm/sec in the unmodie d museum.
555 citations
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TL;DR: The recent flurry of research describing the comparative biology of seeds is discussed, and a special emphasis on the evolution of dormancy, the characteristic of seeds that allows for long 'distance' time travel is placed.
Abstract: Summary The evolution of the seed represents a remarkable life-history transition for photosynthetic organisms. Here, we review the recent literature and historical understanding of how and why seeds evolved. Answering the ‘how’ question involves a detailed understanding of the developmental morphology and anatomy of seeds, as well as the genetic programs that determine seed size. We complement this with a special emphasis on the evolution of dormancy, the characteristic of seeds that allows for long ‘distance’ time travel. Answering the ‘why’ question involves proposed hypotheses of how natural selection has operated to favor the seed life-history phenomenon. The recent flurry of research describing the comparative biology of seeds is discussed. The review will be divided into sections dealing with: (1) the development and anatomy of seeds; (2) the endosperm; (3) dormancy; (4) early seed-like structures and the transition to seeds; and (5) the evolution of seed size (mass). In many cases, a special distinction is made between angiosperm and gymnosperm seeds. Finally, we make some recommendations for future research in seed biology. Contents Summary 817
555 citations
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TL;DR: The clinical and genetic features of VHL disease are reviewed, the molecular pathogenesis is reviewed and clinical management and tumour surveillance strategies are outlined.
Abstract: The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations predispose to the development of a variety of tumours (most commonly retinal and central nervous system haemangioblastomas, clear cell renal carcinoma and phaeochromocytomas). Here, we review the clinical and genetic features of VHL disease, briefly review the molecular pathogenesis and outline clinical management and tumour surveillance strategies.
553 citations
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TL;DR: The participation of superoxide radicals, hydrogen peroxide, and hydroxyl radicals in ROI metabolism was demonstrated with specific in vivo assays, suggesting ROI production by germinating seeds represents an active, developmentally controlled physiological function, presumably for protecting the emerging seedling against attack by pathogens.
Abstract: Germination of radish (Raphanus sativus cv Eterna) seeds can be inhibited by far-red light (high-irradiance reaction of phytochrome) or abscisic acid (ABA). Gibberellic acid (GA3) restores full germination under far-red light. This experimental system was used to investigate the release of reactive oxygen intermediates (ROI) by seed coats and embryos during germination, utilizing the apoplastic oxidation of 2′,7′-dichlorofluorescin to fluorescent 2′,7′-dichlorofluorescein as an in vivo assay. Germination in darkness is accompanied by a steep rise in ROI release originating from the seed coat (living aleurone layer) as well as the embryo. At the same time as the inhibition of germination, far-red light and ABA inhibit ROI release in both seed parts and GA3 reverses this inhibition when initiating germination under far-red light. During the later stage of germination the seed coat also releases peroxidase with a time course affected by far-red light, ABA, and GA3. The participation of superoxide radicals, hydrogen peroxide, and hydroxyl radicals in ROI metabolism was demonstrated with specific in vivo assays. ROI production by germinating seeds represents an active, developmentally controlled physiological function, presumably for protecting the emerging seedling against attack by pathogens.
553 citations
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University of Amsterdam1, University of Bologna2, University of Mainz3, University of Coimbra4, University of Bern5, Columbia University6, Weizmann Institute of Science7, New York University Abu Dhabi8, University of Zurich9, Rensselaer Polytechnic Institute10, Max Planck Society11, Stockholm University12, University of Nantes13, Karlsruhe Institute of Technology14, University of Münster15, University of Chicago16, Arizona State University17, Purdue University18, Rice University19, University of California, San Diego20, University of Freiburg21, Dresden University of Technology22, Imperial College London23, University of California, Los Angeles24
TL;DR: DARk matter WImp search with liquid xenoN (DARWIN) as mentioned in this paper is an experiment for the direct detection of dark matter using a multi-ton liquid xenon time projection chamber at its core.
Abstract: DARk matter WImp search with liquid xenoN (DARWIN(2)) will be an experiment for the direct detection of dark matter using a multi-ton liquid xenon time projection chamber at its core. Its primary g ...
553 citations
Authors
Showing all 42309 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mark Hallett | 186 | 1170 | 123741 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Anders Björklund | 165 | 769 | 84268 |
Si Xie | 148 | 1575 | 120243 |
Kypros H. Nicolaides | 147 | 1302 | 87091 |
Peter J. Schwartz | 147 | 647 | 107695 |
Michael E. Phelps | 144 | 637 | 77797 |
Martin Erdmann | 144 | 1562 | 100470 |
Holger J. Schünemann | 141 | 810 | 113169 |
Maksym Titov | 139 | 1573 | 128335 |
Karl Jakobs | 138 | 1379 | 97670 |
Annette Peters | 138 | 1114 | 101640 |
Suman Bala Beri | 137 | 1608 | 104798 |
Bert Sakmann | 137 | 283 | 90979 |
Vipin Bhatnagar | 137 | 1756 | 104163 |