Institution
University of Freiburg
Education•Freiburg, Baden-Württemberg, Germany•
About: University of Freiburg is a education organization based out in Freiburg, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 41992 authors who have published 77296 publications receiving 2896269 citations. The organization is also known as: alberto-ludoviciana & Albert-Ludwigs-Universität Freiburg.
Topics: Population, Transplantation, Gene, Large Hadron Collider, Medicine
Papers published on a yearly basis
Papers
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Catholic University of the Sacred Heart1, Harvard University2, Columbia University3, Stanford University4, University of Western Ontario5, Washington University in St. Louis6, University of Texas Southwestern Medical Center7, University of Freiburg8, Children's Memorial Hospital9, University of California, Los Angeles10, University of Gothenburg11, Biogen Idec12, Nemours Foundation13
TL;DR: Among children with later‐onset SMA, those who received nusinersen had significant and clinically meaningful improvement in motor function as compared with those in the control group.
Abstract: Background Nusinersen is an antisense oligonucleotide drug that modulates pre–messenger RNA splicing of the survival motor neuron 2 (SMN2) gene. It has been developed for the treatment of spinal muscular atrophy (SMA). Methods We conducted a multicenter, double-blind, sham-controlled, phase 3 trial of nusinersen in 126 children with SMA who had symptom onset after 6 months of age. The children were randomly assigned, in a 2:1 ratio, to undergo intrathecal administration of nusinersen at a dose of 12 mg (nusinersen group) or a sham procedure (control group) on days 1, 29, 85, and 274. The primary end point was the least-squares mean change from baseline in the Hammersmith Functional Motor Scale–Expanded (HFMSE) score at 15 months of treatment; HFMSE scores range from 0 to 66, with higher scores indicating better motor function. Secondary end points included the percentage of children with a clinically meaningful increase from baseline in the HFMSE score (≥3 points), an outcome that indicates impro...
846 citations
TL;DR: A unique in vivo role of DCs for the priming of NK cells is defined, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system.
839 citations
John H. Werren1, Stephen Richards2, Christopher A. Desjardins1, Oliver Niehuis3 +158 more•Institutions (58)
TL;DR: Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation.
Abstract: We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation. Newly developed genome resources advance Nasonia for genetic research, accelerate mapping and cloning of quantitative trait loci, and will ultimately provide tools and knowledge for further increasing the utility of parasitoids as pest insect-control agents.
838 citations
University of Cologne1, University of Freiburg2, Fred Hutchinson Cancer Research Center3, University of Regensburg4, University of Liverpool5, Lund University6, University of Basel7, Discovery Institute8, Imperial College London9, Northwestern University10, National Institutes of Health11, Stanford University12, University of Manchester13, French Institute of Health and Medical Research14, Washington University in St. Louis15, Yokohama City University16, Karolinska Institutet17, Vanderbilt University18, Harvard University19, Max Planck Society20, Osaka University21, University of Copenhagen22, Thomas Jefferson University23, University of Helsinki24, University of Erlangen-Nuremberg25, Rutgers University26
TL;DR: A new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers is introduced, which is introduced for laminin trimers.
836 citations
TL;DR: The data suggest that IL‐6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.
828 citations
Authors
Showing all 42309 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Mark Hallett | 186 | 1170 | 123741 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Anders Björklund | 165 | 769 | 84268 |
| Si Xie | 148 | 1575 | 120243 |
| Kypros H. Nicolaides | 147 | 1302 | 87091 |
| Peter J. Schwartz | 147 | 647 | 107695 |
| Michael E. Phelps | 144 | 637 | 77797 |
| Martin Erdmann | 144 | 1562 | 100470 |
| Holger J. Schünemann | 141 | 810 | 113169 |
| Maksym Titov | 139 | 1573 | 128335 |
| Karl Jakobs | 138 | 1379 | 97670 |
| Annette Peters | 138 | 1114 | 101640 |
| Suman Bala Beri | 137 | 1608 | 104798 |
| Bert Sakmann | 137 | 283 | 90979 |
| Vipin Bhatnagar | 137 | 1756 | 104163 |