Institution
University of Freiburg
Education•Freiburg, Baden-Württemberg, Germany•
About: University of Freiburg is a education organization based out in Freiburg, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 41992 authors who have published 77296 publications receiving 2896269 citations. The organization is also known as: alberto-ludoviciana & Albert-Ludwigs-Universität Freiburg.
Topics: Population, Transplantation, Gene, Large Hadron Collider, Medicine
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Johns Hopkins University1, University of Freiburg2, University of Lübeck3, University of Regensburg4, University of Washington5, University of Maryland, Baltimore6, Washington University in St. Louis7, Boston University8, University of Iceland9, National Institutes of Health10, Memorial Hospital of South Bend11, Erasmus University Rotterdam12, University of Greifswald13, McMaster University14, Mayo Clinic15, University of Mainz16, Wake Forest University17, Harvard University18, Swiss Tropical and Public Health Institute19, University of Basel20, Innsbruck Medical University21, Leipzig University22, Western General Hospital23, University of Texas Health Science Center at Houston24, Cedars-Sinai Medical Center25, University of Pittsburgh26, Ludwig Maximilian University of Munich27, University of Ulm28, University of Edinburgh29, University of Split30, University of Zagreb31, Uppsala University32, University of Kiel33, University of London34, University of Oxford35, Amgen36, University of Michigan37, University of Geneva38, Capital Medical University39, University of California, San Francisco40, Heidelberg University41
TL;DR: The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry to identify new susceptibility loci for reduced renal function as estimated by serum creatinine, serum cystatin c and CKD.
Abstract: Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
756 citations
TL;DR: Insight is provided into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.
Abstract: Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system1-4. These highly diverse and specialized functions may be executed by subsets of microglia that already exist in situ, or by specific subsets of microglia that develop from a homogeneous pool of cells on demand. However, little is known about the presence of spatially and temporally restricted subclasses of microglia in the central nervous system during development or disease. Here we combine massively parallel single-cell analysis, single-molecule fluorescence in situ hybridization, advanced immunohistochemistry and computational modelling to comprehensively characterize subclasses of microglia in multiple regions of the central nervous system during development and disease. Single-cell analysis of tissues of the central nervous system during homeostasis in mice revealed specific time- and region-dependent subtypes of microglia. Demyelinating and neurodegenerative diseases evoked context-dependent subtypes of microglia with distinct molecular hallmarks and diverse cellular kinetics. Corresponding clusters of microglia were also identified in healthy human brains, and the brains of patients with multiple sclerosis. Our data provide insights into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.
755 citations
deCODE genetics1, University of Iceland2, University of Western Australia3, Sir Charles Gairdner Hospital4, University Medical Center Groningen5, University of Freiburg6, University of Groningen7, Queen's University8, University of Cologne9, Sogang University10, Soonchunhyang University11, Copenhagen University Hospital12, Uppsala University13, The Chinese University of Hong Kong14, Duke University15, Emory University16, University of Pennsylvania17, University of Otago18, University of Verona19
TL;DR: A genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly with myocardial infarction in six different populations.
Abstract: Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
754 citations
TL;DR: In this article, the impact of guidance on the efficacy of Internet-based interventions was systematically reviewed and a systematic search of MEDLINE, CENTRAL and PsycINFO, PsycARTICLES and Psyndex (search date 4th June 2013) was conducted.
753 citations
Purdue University1, Kanazawa University2, National Institutes of Natural Sciences, Japan3, Graduate University for Advanced Studies4, Monash University5, University of California, Davis6, Pennsylvania State University7, University at Buffalo8, New York Botanical Garden9, University of Regina10, University of Arizona11, University of Georgia12, University of Potsdam13, Salk Institute for Biological Studies14, Charles University in Prague15, College of William & Mary16, University of California, San Diego17, École normale supérieure de Lyon18, Carnegie Institution for Science19, Hokkaido University20, University of Jena21, Martin Luther University of Halle-Wittenberg22, University of Copenhagen23, Nagoya University24, University of Tokyo25, Free University of Berlin26, University of Tsukuba27, University of Rostock28, University of Tübingen29, Nara Institute of Science and Technology30, Mayo Clinic31, University of California, Berkeley32, Rutgers University33, National Institute of Genetics34, Max Planck Society35, University of Tennessee Health Science Center36, University of Washington37, Dalhousie University38, University of Oxford39, University of Freiburg40, University of Los Andes41, University of Rhode Island42, Joint BioEnergy Institute43, Ruhr University Bochum44, Texas A&M University45, Osaka University46, Cornell University47, Cold Spring Harbor Laboratory48, University of Burgundy49, Utah State University50, United States Department of Energy51
TL;DR: The genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported, is reported, finding that the transition from a gametophytes- to a sporophyte-dominated life cycle required far fewer new genes than the Transition from a non Seed vascular to a flowering plant.
Abstract: Vascular plants appeared ~410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
750 citations
Authors
Showing all 42309 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Mark Hallett | 186 | 1170 | 123741 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Anders Björklund | 165 | 769 | 84268 |
| Si Xie | 148 | 1575 | 120243 |
| Kypros H. Nicolaides | 147 | 1302 | 87091 |
| Peter J. Schwartz | 147 | 647 | 107695 |
| Michael E. Phelps | 144 | 637 | 77797 |
| Martin Erdmann | 144 | 1562 | 100470 |
| Holger J. Schünemann | 141 | 810 | 113169 |
| Maksym Titov | 139 | 1573 | 128335 |
| Karl Jakobs | 138 | 1379 | 97670 |
| Annette Peters | 138 | 1114 | 101640 |
| Suman Bala Beri | 137 | 1608 | 104798 |
| Bert Sakmann | 137 | 283 | 90979 |
| Vipin Bhatnagar | 137 | 1756 | 104163 |