Institution
University of Freiburg
Education•Freiburg, Baden-Württemberg, Germany•
About: University of Freiburg is a education organization based out in Freiburg, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 41992 authors who have published 77296 publications receiving 2896269 citations. The organization is also known as: alberto-ludoviciana & Albert-Ludwigs-Universität Freiburg.
Topics: Population, Transplantation, Gene, Large Hadron Collider, Medicine
Papers published on a yearly basis
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Staatliches Museum für Naturkunde Stuttgart1, University of Freiburg2, Heidelberg Institute for Theoretical Studies3, University of Bonn4, Australian National University5, National Scientific and Technical Research Council6, University of California, Riverside7, Rutgers University8, Naturhistorisches Museum9, National University of Singapore10, University of Castilla–La Mancha11, University of Würzburg12, University of Copenhagen13, China Agricultural University14, Arizona State University15
TL;DR: The results reveal that the extant sawfly diversity is largely the result of a previously unrecognized major radiation of phytophagous Hymenoptera that did not lead to wood-dwelling and parasitoidism.
549 citations
TL;DR: How understanding the principles of codon bias and translation can contribute to improved protein production and developments in synthetic biology is discussed.
549 citations
University of Michigan1, Newcastle University2, University of Cologne3, Simon Fraser University4, Harvard University5, University of Hyogo6, Max Planck Society7, Peking University8, University of California, San Diego9, University of Zurich10, University of Washington11, Hannover Medical School12, University of Freiburg13
TL;DR: These findings help establish the link between centrosome function, tissue architecture and transcriptional control in the pathogenesis of cystic kidney disease, retinal degeneration, and central nervous system development.
Abstract: The molecular basis of nephronophthisis, the most frequent genetic cause of renal failure in children and young adults, and its association with retinal degeneration and cerebellar vermis aplasia in Joubert syndrome are poorly understood. Using positional cloning, we here identify mutations in the gene CEP290 as causing nephronophthisis. It encodes a protein with several domains also present in CENPF, a protein involved in chromosome segregation. CEP290 (also known as NPHP6) interacts with and modulates the activity of ATF4, a transcription factor implicated in cAMP-dependent renal cyst formation. NPHP6 is found at centrosomes and in the nucleus of renal epithelial cells in a cell cycle-dependent manner and in connecting cilia of photoreceptors. Abrogation of its function in zebrafish recapitulates the renal, retinal and cerebellar phenotypes of Joubert syndrome. Our findings help establish the link between centrosome function, tissue architecture and transcriptional control in the pathogenesis of cystic kidney disease, retinal degeneration, and central nervous system development.
549 citations
TL;DR: Verapamil and D 600 differ in this respect from common local anesthetic compounds such as xylocaine (lidocaine) or procaine which interfere much more with the transmembrane Na conductivity than with the Ca conductivity.
Abstract: According to earlier studies on mammalian papillary muscles, verapamil and compound D 600 (a methoxy-derivative of verapamil) can abolish the Ca dependent contractile responses completely whilst the Na dependent action potentials persist. In an attempt to clarify the mechanism of action separate measurements of the transmembrane Na and Ca currents have been performed on ventricular trabeculae of cats using a special voltage clamp technique. The following results were obtained:
As a functional significance of this dual membrane transport system it is possible to change the contractile force by inotropic substances which act on the Ca conductivity without a corresponding influence on excitation.
547 citations
TL;DR: Patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal slices show that inactivation of presynaptic K(+) channels contributes to the control of efficacy of a glutamatergic synapse in the cortex.
546 citations
Authors
Showing all 42309 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Mark Hallett | 186 | 1170 | 123741 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Anders Björklund | 165 | 769 | 84268 |
| Si Xie | 148 | 1575 | 120243 |
| Kypros H. Nicolaides | 147 | 1302 | 87091 |
| Peter J. Schwartz | 147 | 647 | 107695 |
| Michael E. Phelps | 144 | 637 | 77797 |
| Martin Erdmann | 144 | 1562 | 100470 |
| Holger J. Schünemann | 141 | 810 | 113169 |
| Maksym Titov | 139 | 1573 | 128335 |
| Karl Jakobs | 138 | 1379 | 97670 |
| Annette Peters | 138 | 1114 | 101640 |
| Suman Bala Beri | 137 | 1608 | 104798 |
| Bert Sakmann | 137 | 283 | 90979 |
| Vipin Bhatnagar | 137 | 1756 | 104163 |