University of Illinois at Chicago

About: University of Illinois at Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 57071 authors who have published 110536 publications receiving 4264936 citations.

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts.

Abstract: The occurrence of DNA double strand breaks induces cell cycle arrest in mortal and immortal human cells. In normal, mortal fibroblasts this block to proliferation is permanent. It depends on the growth regulator p53 and a protein p53 induces, the cyclin dependent kinase inhibitor, p21. We show here that following DNA damage in mortal fibroblasts, the induction of p21 and p53 is to a large degree shortlived. By 8 days after a brief exposure to DNA strand breaking agents, bleomycin or actinomycin D, p53 protein is at baseline levels, while the p53 transactivation level is only slightly above its baseline. By this time the concentration of p21 protein, which goes up as high as 100-fold shortly after treatment, is down to just 2-4-fold over baseline levels. Following the drop in p21 concentration a large increase in the expression level of the tumor suppressor gene p16INK4a is observed. This scenario, where a transient increase in p21 is followed by a delayed induction of p16INK4a, also happens with the permanent arrest that occurs with cellular senescence. In fact, these cells treated with agents that cause DNA double strand breaks share a number of additional markers with senescent cells. Our findings indicate that these cells are very similar to senescent cells and that they have additional factor(s) beside p21 and p53 that maintain cell cycle arrest.

Leveraging Meta-path based Context for Top- N Recommendation with A Neural Co-Attention Model

Abstract: Heterogeneous information network (HIN) has been widely adopted in recommender systems due to its excellence in modeling complex context information. Although existing HIN based recommendation methods have achieved performance improvement to some extent, they have two major shortcomings. First, these models seldom learn an explicit representation for path or meta-path in the recommendation task. Second, they do not consider the mutual effect between the meta-path and the involved user-item pair in an interaction. To address these issues, we develop a novel deep neural network with the co-attention mechanism for leveraging rich meta-path based context for top-N recommendation. We elaborately design a three-way neural interaction model by explicitly incorporating meta-path based context. To construct the meta-path based context, we propose to use a priority based sampling technique to select high-quality path instances. Our model is able to learn effective representations for users, items and meta-path based context for implementing a powerful interaction function. The co-attention mechanism improves the representations for meta-path based con- text, users and items in a mutual enhancement way. Extensive experiments on three real-world datasets have demonstrated the effectiveness of the proposed model. In particular, the proposed model performs well in the cold-start scenario and has potentially good interpretability for the recommendation results.

A Randomized, Controlled Trial of a Group Intervention to Reduce Fear of Falling and Associated Activity Restriction in Older Adults

Abstract: A randomized, single-blind controlled trial was conducted to test the efficacy of a community-based group intervention to reduce fear of falling and associated restrictions in activity levels among older adults. A sample of 434 persons age 60+ years, who reported fear of falling and associated activity restriction, was recruited from 40 senior housing sites in the Boston metropolitan area. Data were collected at baseline, and at 6-week, 6-month, and 12-month follow-ups. Compared with contact control subjects, intervention subjects reported increased levels of intended activity (p < .05) and greater mobility control (p < .05) immediately after the intervention. Effects at 12 months included improved social function (p < .05) and mobility range (p < .05). The intervention had immediate but modest beneficial effects that diminished over time in the setting with no booster intervention.

The inguinal paravascular technic of lumbar plexus anesthesia: the "3-in-1 block".

Abstract: HEN regional anesthesia was still in W its infancy, one of the pioneers in the field, George Hirschel, who in 1911 had described the first axillary approach to the brachial plexus, made the following statement: “Local anaesthesia for operations on the lower limb has not kept pace with the advances of that of the upper limb. The anaesthetization of the lumbar plexus in a manner analogous to that of the brachial has not so far been successful.”l Over the next half century these words have been echoed by many of the great regional anesthetists of the past,2-6 because, as Dogliotti so aptly pointed out, “The nerve trunks of the lumbar plexus, which run into the inferior extremity, are at a great distance from each other, so much so that in order to produce anesthesia. multide mocedures are it is difficult to obtain complete anesthesia, and there is frequent failure of the blocks.”fi

Corporate Investment and Stock Market Listing: A Puzzle?

Abstract: We investigate whether short-termism distorts the investment decisions of stock market listed firms. To do so, we compare the investment behavior of observably similar public and private firms using a new data source on private U.S. firms, assuming for identification that closely held private firms are subject to fewer short-termist pressures. Our results show that compared to private firms, public firms invest substantially less and are less responsive to changes in investment opportunities, especially in industries in which stock prices are most sensitive to earnings news. These findings are consistent with the notion that short-termist pressures distort their investment decisions.